Tsepamisa maikutlo ho Cellulose ethers

Joang ho lokisa tharollo ea ho roala HPMC?

Ho lokisa tharollo ea hydroxypropyl methylcellulose (HPMC) ho kenyelletsa mehato e mengata mme ho hloka tlhokomelo e hlokolosi ho lintlha. HPMC e atisa ho sebelisoa e le thepa ea ho roala filimi indastering ea meriana le ea lijo. Litharollo tsa ho roala li sebelisoa matlapeng kapa li-granules ho fana ka lera le sireletsang, ho ntlafatsa ponahalo, le ho nolofatsa ho metsa.

1. Kenyelletso ea ho roala HPMC:

Hydroxypropylmethylcellulose (HPMC) ke polymer e entsoeng ka selulose e nkiloeng ho likhoele tsa semela. Ka lebaka la thepa ea eona ea ho etsa filimi le e teteaneng, e sebelisoa haholo ka ho roala lifilimi ho indasteri ea meriana le ea lijo.

2. Lisebelisoa tse hlokahalang:

Hydroxypropyl methylcellulose phofo
Hloekisa metsi
Lijana tsa polasetiki kapa tse se nang tšepe
Thepa e hlohlelletsang (mohlala, magnetic stirrer)
Lisebelisoa tsa ho lekanya (likarolo, lisilindara)
pH metara
Plastiki kapa tšepe e sa hloekang ea ho roala pan
Setofo sa moea o chesang

3.lenaneo:

Leka HPMC:

Lekanya ka nepo palo e hlokahalang ea phofo ea HPMC ho latela mokhoa o lakatsehang oa ho roala. Hangata likhakanyo li pakeng tsa 2% le 10%.

Lokisetsa metsi a hloekisitsoeng:

Sebelisa metsi a hloekisitsoeng ho netefatsa hore ha a na litšila tse ka amang boleng ba ho roala. Metsi a lokela ho ba mocheso oa kamore.

Phatlalatso ea HPMC:

Butle-butle eketsa phofo ea HPMC e lekantsoeng metsing a hloekisitsoeng ha u ntse u susumetsa ka ho tsoelang pele. Sena se thibela li-clumps ho theha.

Hlohlelletsa:

Hlohlelletsa motsoako o sebelisa mochine oa magnetic stirrer kapa sesebelisoa se seng se loketseng se susumetsang ho fihlela phofo ea HPMC e hasane ka ho feletseng metsing.

Phetoho ea pH:

Lekanya pH ya tharollo ya HPMC o sebedisa pH meter. Haeba ho hlokahala, pH e ka fetoloa ka ho eketsa palo e nyane ea asiti kapa setsi ho latela. PH e nepahetseng ea ho roala filimi hangata e pakeng tsa 5.0 le 7.0.

Moisturizing le botsofali:

Tharollo ea HPMC e lumelloa ho fana ka metsi le ho tsofala ka nako e itseng. Sena se ntlafatsa thepa ea ho etsa lifilimi. Nako ea botsofali e ka 'na ea fapana empa hangata e pakeng tsa lihora tse 2 ho isa ho tse 24.

sefe:

Sefa tharollo ea HPMC ho tlosa likaroloana tse sa qhibilihang kapa litšila. Mohato ona ke oa bohlokoa ho fumana tharollo e boreleli, e hlakileng ea ho roala.

Ho lokisoa ha viscosity:

Lekanya viscosity ea tharollo 'me u e fetole ho ea boemong bo lakatsehang. Viscosity e ama ho tšoana le botenya ba ho roala.

Teko e tsamaellana:

Lekola ho lumellana ha tharollo ea ho roala le substrate (matlapa kapa granules) ho etsa bonnete ba ho khomarela hantle le sebopeho sa filimi.

Mokhoa oa ho roala:

Sebelisa pane e loketseng ea ho roala 'me u sebelise mochini oa ho roala ho kenya tharollo ea HPMC ho matlapa kapa li-granules. Fetola lebelo la pitsa le mocheso oa moea bakeng sa ho roala hantle.

ho omisa:

Matlapa kapa li-granules tse koahetsoeng li omisitsoe ka ontong ea moea o chesang o laoloang ke mocheso ho fihlela botenya bo lakatsehang bo finyelloa.

QC:

Etsa tlhahlobo ea taolo ea boleng ba lihlahisoa tse koahetsoeng ho kenyelletsa ponahalo, botenya le thepa ea ho qhibiliha.

4. Qetellong:

Ho lokisoa ha litharollo tsa ho roala HPMC ho kenyelletsa letoto la mehato e nepahetseng ho netefatsa boleng le katleho ea ho roala. Ho khomarela mekhoa e behiloeng le mehato ea ho laola boleng ke habohlokoa bakeng sa ho fumana liphello tse tsitsitseng le tse ka tšeptjoang indastering ea meriana le ea lijo. Kamehla latela Mekhoa e Metle ea Tlhahiso (GMP) le litataiso tse amanang le tsona nakong ea ho roala.


Nako ea poso: Jan-18-2024
Moqoqo oa Marang-rang oa WhatsApp!