Hydroxypropylmethylcellulose (HPMC) ke polymer e nkiloeng ho cellulose e sebelisoang hangata liindastering tse fapaneng, ho kenyeletsoa meriana, lijo le kaho. Mocheso o ka ba le tšusumetso e kholo ts'ebetsong le boitšoarong ba HPMC.
1. Sollubility le ho qhibiliha:
Solubility: HPMC e bonts'a ho qhibiliha ho itšetlehileng ka mocheso. Ka kakaretso, e qhibiliha haholo metsing a batang ho feta metsing a chesang. Thepa ena e bohlokoa bakeng sa litlhare tsa meriana tse hlokang tokollo e laoloang ea lithethefatsi.
Dissolution: Sekhahla sa ho qhibiliha ha metsoako ea HPMC se angoa ke mocheso. Lithempereichara tse phahameng ka kakaretso li lebisa ho qhaleng ka potlako, ka hona li ama kinetics ea ho lokolloa ha lithethefatsi lits'ebetsong tsa meriana.
2. Gelation le viscosity:
Gelation: HPMC e ka etsa gel ka tharollo e nang le metsi, mme ts'ebetso ea gelation e angoa ke mocheso. Hangata gelation e khothaletsoa ka mocheso o phahameng, e leng se etsang hore ho thehoe marang-rang a tsitsitseng a gel.
Viscosity: Thempereichara e bapala karolo ea bohlokoa ho khethollang viscosity ea tharollo ea HPMC. Ka kakaretso, ho eketseha ha mocheso ho baka ho fokotseha ha viscosity. Thepa ena e bohlokoa bakeng sa ho etsa lirafshoa, likhomaretsi le lits'ebetso tse ling tse hlokang taolo ea viscosity.
3. Sebopeho sa lifilimi:
Ho roala lifilimi: indastering ea meriana, HPMC e sebelisoa haholo bakeng sa ho roala filimi ea matlapa. Mocheso o ama thepa ea ho etsa filimi ea tharollo ea HPMC. Lithempereichara tse phahameng li ka ntlafatsa mokhoa oa ho etsa filimi le ho ama boleng le litšobotsi tsa filimi ea ho roala.
4. Thermal botsitso:
Ho senyeha: HPMC e bonts'a botsitso ba mocheso ka har'a mefuta e itseng ea mocheso. Ka ntle ho sebaka sena, ho senyeha ha mocheso ho ka 'na ha etsahala, ho fella ka tahlehelo ea viscosity le lintho tse ling tse lakatsehang. Botsitso ba mocheso oa HPMC bo tlameha ho nahanoa lits'ebetsong tse fapaneng.
5. Phetoho ea mohato:
Glass Transition Temperature (Tg): HPMC e kena phetohong ea khalase ka mocheso o itseng o bitsoang mocheso oa phetoho ea khalase (Tg). Ka holimo ho Tg, polymer e fetoha ho tloha ho khalase ho ea sebakeng sa rabara, e amang thepa ea eona ea mochine.
6. Litšebelisano tsa lithethefatsi le Polymer:
Complex Formation: Meetsong ea meriana, mocheso o ama tšebelisano lipakeng tsa HPMC le moriana. Liphetoho tsa mocheso li ka lebisa ho thehoeng ha li-complexes, tse amang ho qhibiliha ha lithethefatsi le ho lokolloa.
7. Ho tsitsa ha foromo:
Freeze-Thaw Stability: HPMC e atisa ho sebelisoa ha ho etsoa lihatsetsi, joalo ka li-dessert tse leqhoa. Ho tsitsa ha eona nakong ea lipotoloho tsa ho qhibiliha ha leqhoa ho angoa ke liphetoho tsa mocheso. Ho utloisisa liphello tsa mocheso ke habohlokoa ho boloka boleng ba sehlahisoa.
Mocheso o na le tšusumetso e kholo ho solubility, dissolution, gelation, viscosity, sebopeho sa filimi, botsitso ba mocheso, liphetoho tsa mekhahlelo, litšebelisano tsa lithethefatsi-polymer, le botsitso ba tlhahiso ea HPMC. Bafuputsi le baetsi ba lihlahisoa ba hloka ho nahana ka hloko ka thepa ena e amanang le mocheso ha ba sebelisa HPMC lits'ebetsong tse fapaneng.
Nako ea poso: Jan-20-2024