Hydroxypropyl methylcellulose (HPMC) ke polymer e feto-fetohang e sebelisoang hangata ho etsa meriana, litlolo, thepa ea kaho le lihlahisoa tsa lijo. pH, kapa tekanyo ea acidity kapa alkalinity ea tharollo, e ka ama haholo thepa le ts'ebetso ea HPMC.
Sollubility:
HPMC e bonts'a ho qhibiliha ho itšetlehileng ka pH. Ka pH e tlase (maemo a acidic), HPMC e atisa ho sa qhibilihe ka lebaka la protonation ea lihlopha tsa eona tsa hydroxyl, e leng se lebisang ho eketseha ha intermolecular hydrogen bonding le ho fokotseha ha ho qhibiliha. Ha pH e ntse e eketseha (e fetoha alkaline e eketsehileng), HPMC e fetoha haholo ka lebaka la ho senyeha ha lihlopha tsa eona tse sebetsang.
The solubility ea HPMC e ka leveraged ho metsoako ea meriana ho laola ho lokolloa ha lithethefatsi. Ka mohlala, li-hydrogel tse thehiloeng ho pH-sensitive HPMC, li ka etsoa ho lokolla lithethefatsi ka mokhoa o itšetlehileng ka pH, moo polima e ruruhang le ho ntša moriana habonolo maemong a itseng a pH.
Viscosity:
Viscosity ea tharollo ea HPMC e susumetsoa ke pH. Ka pH e tlase, limolek'hule tsa HPMC li atisa ho bokellana ka lebaka la ho eketseha ha hydrogen bonding, e lebisang ho viscosity e phahameng. Ha pH e ntse e eketseha, ho nyenyefatsa lipakeng tsa liketane tsa HPMC tse qosoang hampe ka lebaka la deprotonation ho fokotsa ho kopanya, ho bakang viscosity e tlase.
Lits'ebetsong tse joalo ka meriana le litlolo, ho laola viscosity ea tharollo ea HPMC ho bohlokoa bakeng sa ho fihlela litšobotsi tse lakatsehang tsa sehlahisoa. Phetoho ea pH e ka sebelisoa ho hlophisa viscosity ho fihlela litlhoko tse ikhethileng tsa ho theha.
Tlhahiso ea lifilimi:
Hangata HPMC e sebelisoa ho lokiseng lifilimi bakeng sa litsamaiso tsa phepelo ea lithethefatsi, likoahelo le thepa ea ho paka. PH ea tharollo ea ho etsa lifilimi e ama thepa ea lifilimi tse hlahisoang.
Ka pH e tlase, lifilimi tsa HPMC li na le ho ba compact ho feta le ho teteana ka lebaka la ho bokellana ha limolek'hule. Ka lehlakoreng le leng, ka pH e phahameng, lifilimi tsa HPMC li bonts'a porosity e phahameng le ho feto-fetoha ha maemo ka lebaka la ho fokotsa ho kopanya le ho eketsa ho qhibiliha.
Emulsification le botsitso:
Lits'ebetsong tsa litlolo le lijo, HPMC e sebelisoa joalo ka emulsifier le stabilizer. PH ea tsamaiso e susumetsa emulsification le botsitso ba thepa ea HPMC.
Maemong a fapaneng a pH, limolek'hule tsa HPMC li ba le liphetoho tse fapaneng, tse amang bokhoni ba tsona ba ho theha li-emulsion tse tsitsitseng. Ho ntlafatsa pH ho bohlokoa ho fihlela botsitso le sebopeho se lakatsehang sa emulsion lihlahisoa tsa litlolo le lijo.
Gelation:
HPMC e ka etsa li-gel tse fetolehang ka mocheso o phahameng. PH ea tharollo e susumetsa boitšoaro ba gelation ba HPMC.
Ka lihlahisoa tsa lijo tse kang li-dessert le li-sauces, phetoho ea pH e ka sebelisoa ho laola thepa ea gelation ea HPMC le ho finyella sebopeho le molomo o lakatsehang.
Ho lumellana le Lisebelisoa tse ling:
PH ea sebopeho e ka ama tšebelisano ea HPMC le metsoako e meng. Mohlala, litlamong tsa meriana, pH e ka ama botsitso ba litšebelisano tsa lithethefatsi-HPMC.
Ho ntlafatsa pH ho bohlokoa ho netefatsa tšebelisano lipakeng tsa HPMC le likarolo tse ling ha ho etsoa, ka tsela eo ho boloka botšepehi le ts'ebetso ea sehlahisoa.
pH e susumetsa haholo ho solubility, viscosity, sebopeho sa filimi, emulsification, gelation, le ho lumellana ha HPMC lits'ebetsong tse fapaneng. Ho utloisisa boits'oaro bo itšetlehileng ka pH ea HPMC ho bohlokoa bakeng sa ho ntlafatsa litlolo le ho fihlela litšoaneleho tse lakatsehang tsa sehlahisoa.
Nako ea poso: Apr-18-2024