Hydroxypropyl methylcellulose (HPMC) ke polymer e feto-fetohang e sebelisoang haholo liindastering tse kang tsa meriana, lijo le kaho. Ts'ebetso ea eona e fapana ho latela limaraka tsa eona, tse fapaneng ka mekhahlelo e kang viscosity, degree of substitution, particle size, le bohloeki. Ho utloisisa hore na limaraka tsena li ama ts'ebetso joang ho bohlokoa bakeng sa ho ntlafatsa ts'ebeliso ea eona lits'ebetsong tse fapaneng.
1. Viscosity
Viscosity ke parameter ea bohlokoa e susumetsang haholo ts'ebetso ea HPMC lits'ebetsong tse fapaneng. Hangata e lekanyetsoa ka centipoises (cP) 'me e ka tloha tlase haholo ho ea holimo haholo.
Meriana ea Meriana: Meetsong ea matlapa, HPMC e nang le viscosity e tlase (mohlala, 5-50 cP) e sebelisoa hangata joalo ka sehokelo hobane e fana ka thepa e lekaneng ea sekhomaretsi ntle le ho ama haholo nako ea ho putlama ha letlapa. HPMC e nang le viscosity e phahameng (mohlala, 1000-4000 cP), ka lehlakoreng le leng, e sebelisoa mefuteng e laoloang ea tokollo. Viscosity e phahameng e liehisa sekhahla sa ho lokolloa ha moriana, ka hona, ho lelefatsa katleho ea moriana.
Kaho: Ka lihlahisoa tse thehiloeng ho samente, HPMC e bohareng ho isa ho e phahameng (mohlala, 100-200,000 cP) e sebelisoa ho matlafatsa ho boloka metsi le ho sebetsa. Limaraka tse phahameng tsa viscosity li fana ka ho boloka metsi hantle le ho ntlafatsa ho khomarela le matla a motsoako, ho etsa hore e be tse loketseng bakeng sa likhomaretsi tsa lithaele le liretse.
2. Degree of Substitution
The degree of substitution (DS) e bolela palo ea lihlopha tsa hydroxyl ho molek'hule ea cellulose tse nketsoeng sebaka ke lihlopha tsa methoxy kapa hydroxypropyl. Phetoho ena e fetola ho solubility, gelation, le thepa ea mocheso ea HPMC.
Sollubility: Litekanyetso tse phahameng tsa DS hangata li eketsa ho qhibiliha ha metsi. Ka mohlala, HPMC e nang le methoxy e phahameng e qhibiliha habonolo metsing a batang, e leng molemo ho fanyeha meriana le li-syrups moo ho hlokahalang ho qhibiliha kapele.
Thermal Gelation: The DS e boetse e ama mocheso oa gelation. HPMC e nang le tekanyo e phahameng ea ho fetola hangata li-gel ka mocheso o tlase, e leng molemo lits'ebetsong tsa lijo moo e ka sebelisoang ho etsa li-gel tse tsitsitseng mocheso. Ka lehlakoreng le leng, DS HPMC e tlase e sebelisoa lits'ebetsong tse hlokang botsitso bo phahameng ba mocheso.
3. Boholo ba Karolo
Kabo ea boholo ba karolo e ama sekhahla sa ho qhibiliha le thepa ea 'mele ea sehlahisoa sa ho qetela.
Meriana ea Meriana: HPMC ea boholo bo bonyenyane e qhibiliha ka potlako, e etsa hore e tšoanelehe bakeng sa lihlahisoa tse tsoang ka potlako. Ka lehlakoreng le leng, boholo ba likaroloana tse kholo li sebelisoa matlapeng a laoloang a lokolloa, moo ho batloang butle-butle ho lelefatsa ho lokolloa ha lithethefatsi.
Kaho: Lits'ebetsong tsa kaho, likaroloana tse ntle tsa HPMC li ntlafatsa homogeneity le botsitso ba motsoako. Sena se bohlokoa bakeng sa ho etsa bonnete ba hore lipente, lirafshoa le likhomaretsi li tšoana hantle.
4. Bohloeki
Ho hloeka ha HPMC, haholo-holo mabapi le boteng ba litšila tse kang litšepe tse boima le lihlapolli tse setseng, ke ntho ea bohlokoa, haholo litlhare le lisebelisoa tsa lijo.
Meriana le Lijo: Limaraka tse phahameng tsa HPMC li bohlokoa ho fihlela litekanyetso tsa taolo le ho netefatsa polokeho. Litšila li ka ama ts'ebetso ea polymer mme tsa baka likotsi tsa bophelo bo botle. HPMC ea boemo ba meriana e tlameha ho latela litataiso tse thata joalo ka tse boletsoeng ho pharmacopeias (USP, EP) bakeng sa litšila.
5. Ts'ebetso e khethehileng ea Kopo
Lisebelisoa tsa Meriana:
Li-Binders le Fillers: Limaraka tse tlase ho isa ho tse mahareng tsa viscosity tsa HPMC (5-100 cP) li khethoa joalo ka li tlamella le li-filler matlapeng, moo li matlafatsang matla a mochini oa letlapa ntle le ho senya ho arohana.
Phatlalatso e Laolang: Limaraka tsa HPMC tse nang le viscosity e phahameng (1000-4000 cP) li loketse liforomo tse laoloang. Ba theha thibelo ea li-gel e tsamaisang ho lokolloa ha lithethefatsi.
Litharollo tsa Ophthalmic: Ultra-high-purity, low-viscosity HPMC (ka tlase ho 5 cP) e sebelisoa ka marotholi a mahlo ho fana ka lubrication ntle le ho baka ho teneha.
Indasteri ea Lijo:
Li-Thickeners le Stabilizers: Limaraka tse tlase ho isa ho tse mahareng tsa viscosity tsa HPMC (5-1000 cP) li sebelisoa ho tenya le ho tsitsisa lihlahisoa tsa lijo. Ba ntlafatsa sebopeho le bophelo ba lishelefo ea li-sauces, liaparo le lintho tsa ho baka.
Dietary Fibre: HPMC e nang le viscosity e phahameng e sebelisoa e le fiber supplement lijong tse nang le khalori e tlase, e fanang ka bongata le ho thusa tšilo ea lijo.
Indasteri ea Kaho:
Lihlahisoa tse Thehiloeng ka Samente le Gypsum: Limaraka tsa HPMC tse Bohareng ho isa ho tse phahameng (100-200,000 cP) li sebelisoa ho ntlafatsa ho boloka metsi, ho sebetsa le ho khomarela. Sena se bohlokoa haholo lits'ebetsong tse kang likhomaretsi tsa lithaele, li-renders le plasters.
Lipente le Liaparo: Limaraka tsa HPMC tse nang le viscosity e loketseng le boholo ba likaroloana li ntlafatsa rheology, boemo le botsitso ba lipente, e leng se lebisang qetellong e ntle le ho phela nako e telele.
Limaraka tse fapaneng tsa HPMC li fana ka mefuta e mengata ea thepa e ka hlophisoang ho latela litlhoko tse ikhethang liindastering tse fapaneng. Khetho ea sehlopha-e ipapisitseng le viscosity, tekanyo ea ho fetola, boholo ba likaroloana, le bohloeki - e phetha karolo ea bohlokoa ho ntlafatseng ts'ebetso bakeng sa ts'ebeliso e lakatsehang. Ka ho utloisisa li-nuances tsena, bahlahisi ba ka khetha boemo bo nepahetseng ba HPMC ho fumana liphetho tse nepahetseng, ekaba litlhare, lijong kapa kahong. Mokhoa ona o hlophisitsoeng o netefatsa katleho ea sehlahisoa, polokeho le boleng, e totobatsang ho feto-fetoha ha maemo le bohlokoa ba HPMC lits'ebetsong tsa indasteri.
Nako ea poso: May-29-2024