Lintlha tse amang viscosity ea hydroxypropyl methylcellulose

Hydroxyl methyl cellulose (HPMC) ke polymer e sebelisoang haholo ho lithethefatsi, litlolo, lijo le liindasteri tse ling. Likarolo tsa eona tse ikhethang, tse kang viscosity e phahameng, bokhoni bo botle ba ho qhibiliha ha metsi le lera, e leng se etsang hore e be karolo ea bohlokoa mefuteng e fapaneng. Viscosity ke karolo ea bohlokoa ea HPMC ts'ebelisong ea eona. Viscosity ea HPMC e angoa ke lintlha tse fapaneng, joalo ka mahloriso, mocheso, pH le boima ba limolek'hule. Ho utloisisa lintlha tse amang viscosity ea HPMC ho bohlokoa bakeng sa ntlafatso. Sengoliloeng sena se bua ka lintlha tse amang viscosity ea hydroxylopyl methyl cellulose.

Tsepamisa maikutlo ho

Khokahano ea HPMC ke e 'ngoe ea lintlha tsa bohlokoa tse amang viscosity ea eona. Viscosity ea tharollo ea HPMC e eketseha ka keketseho ea mahloriso. Sebakeng se tlase, ketane ea polymer ea HPMC e hasane haholo ka har'a solvent, kahoo viscosity e tlase. Leha ho le joalo, maemong a holimo, ketane ea polymer e tloaetse ho sebelisana, e bakang viscosity e phahameng. Ka hona, viscosity ea HPMC e lekana le mahloriso a polymer. Ho tsepamisa mohopolo ho boetse ho ama boits'oaro ba gelization ba HPMC. High-concentration HPMC e ka etsa gel, e leng ea bohlokoa haholo indastering ea meriana le ea lijo.

mocheso

Mocheso ke ntlha e 'ngoe ea bohlokoa e amang viscosity ea hydroxylopenyl cellulose. Viscosity ea HPMC e fokotseha ka ho eketseha ha mocheso. Ketane ea polymer ea HPMC e fetoha phallo e ngata mochesong o phahameng, e bakang viscosity e tlase. Ha ho bapisoa le litharollo tse phahameng tsa mahloriso, phello ea mocheso ho HPMC viscosity e hlakile haholoanyane tharollong e tlase ea mahloriso. Ho eketseha ha mocheso ho tla boela ho ama ho qhibiliha ha HPMC. Ka mocheso o phahameng, ho qhibiliha ha HPMC ho fokotseha, ho fella ka ho fokotseha ha viscosity e bakoang ke ho fokotseha ha ketane ea ketane.

pH

PH ea tharollo ea HPMC ke ntlha e 'ngoe ea bohlokoa e amang viscosity ea eona. HPMC ke polima e nang le asiti e fokolang, e nang le PKA e ka bang 3.5. Ka hona, viscosity ea tharollo ea HPMC e na le maikutlo a pH ea tharollo. Tlas'a boleng ba pH bo phahameng ho feta PKA, sehlopha sa letsoai sa carboxylic acid sa polymer se ne se le tlas'a protonization, e ileng ea etsa hore ho qhibiliha ha HPMC ho eketsehe, 'me viscosity e fokotsehile ka lebaka la ho fokotseha ha litlamo tsa hydrogen tsa ho kopana ha molek'hule. Tlas'a boleng ba pH ka tlase ho PKA, sehlopha sa asiti ea carboxylic ea polymer e ne e le boima, e bakileng ho qhibiliha ho tlase le viscosity e phahameng e bakoang ke ho eketseha ha li-hydrogen bond. Ka hona, boleng bo botle ba pH ba tharollo ea HPMC bo ipapisitse le ts'ebeliso e lebelletsoeng.

Boima ba molek'hule

Boima ba limolek'hule tsa HPMC ke ntlha e 'ngoe ea bohlokoa e amang viscosity ea eona. HPMC ke polymer polymer. Ha boima ba molek'hule ba polymer bo ntse bo eketseha, viscosity ea tharollo ea HPMC e tla eketseha. Sena ke hobane ketane e phahameng ea boima ba limolek'hule ea HPMC e ts'oarehile haholoanyane, e bakang viscosity e eketsehileng. Boima ba limolek'hule tsa polymer bo boetse bo ama HPMC gelization. HPMC polymer e na le monyetla oa ho theha li-gel ho feta lipolymer tse boima ba molek'hule.

Letsoai

Ho eketsa letsoai ho tharollo ea HPMC ho ka ama viscosity ea eona haholo. Letsoai le ama matla a ion a tharollo ea HPMC, e fetolang ho sebelisana ha li-polymers. Ka kakaretso, ho eketsa letsoai ho tharollo ea HPMC ho tla etsa hore viscosity e fokotsehe. Lebaka ke hobane matla a ion a tharollo a fokotseha pakeng tsa matla a limolek'hule pakeng tsa ketane ea polymer ea HPMC, ka hona e fokotsa phokotso ea ketane e kenang, kahoo viscosity e fokotsehile. Phello ea letsoai holim'a viscosity ea tharollo ea HPMC e itšetlehile ka mofuta le mahloriso a letsoai.

ha re phethela

Viscosity ea hydroxydal cibolin ke parameter ea bohlokoa e amang ts'ebeliso ea eona liindastering tse fapaneng. Lintho tse amang HPMC viscosity li kenyelletsa mahloriso, mocheso, pH, boima ba limolek'hule le letsoai. Ho utloisisa lintlha tsena ho HPMC viscosity ho bohlokoa ho ntlafatsa ts'ebeliso ea eona lits'ebetsong tse fapaneng. Tharollo ea HPMC e ka fetoloa ka nepo ho fihlela viscosity e hlokahalang e tobileng.