CMC e laoloang ke mekhoa ea phekolo

CMC (carboxymethylcellulose) ke polymer e qhibilihang ka metsing, e sebelisoang haholo e le mothusi indastering ea meriana. E tsoa ho cellulose, polysaccharide ea tlhaho, ka ho kenyelletsa lihlopha tsa carboxymethyl sebopeho sa eona. CMC e tsejoa ka thepa ea eona e ntle ea ho etsa lifilimi le ho tenya, e e etsa motsoako o fapaneng le oa bohlokoa mefuteng e mengata ea meriana.

Litlhareng tsa meriana, CMC e sebelisoa hangata joalo ka setei, se tsitsitseng le setlolo. E le motenya, CMC e sebelisoa mefuteng e mengata ea litlolo, joalo ka litlolo, litlolo le li-gel, ho fana ka viscosity le ho ntlafatsa sebopeho sa tsona. Sena se thusa ho ntlafatsa botsitso le botsitso ba sehlahisoa, ho etsa hore ho be bonolo ho se sebelisa le ho ba monate ho bakuli ho se sebelisa. CMC e boetse e sebelisoa e le stabilizer ho suspensions le emulsions, ho thusa ho thibela likaroloana ho tloha ho rarolla le ho etsa bonnete ba hore sehlahisoa se lula se le homogeneous. Ho feta moo, CMC e sebelisoa e le setlolo se entsoeng ka letlapa le capsule, ho thusa ho ntlafatsa phallo ea bona le boiketlo ba ho metsa.

E 'ngoe ea lits'ebetso tse atileng haholo tsa kalafo ea CMC ke ho li-ophthalmic formulations. CMC e sebelisoa marotholing a mahlo le meokho ea maiketsetso ho fana ka mafura le ho fokotsa matšoao a mahlo a omileng. Leihlo le omeletseng ke boemo bo tloaelehileng bo hlahang ha mahlo a sa hlahise meokho e lekaneng kapa ha meokho e fetoha mouoane ka potlako. Sena se ka lebisa ho teneha, bofubelu, le ho se phutholohe. CMC ke phekolo e sebetsang bakeng sa leihlo le omeletseng hobane e thusa ho ntlafatsa botsitso le nako ea ho boloka filimi ea ho lla holim'a mahlo a mahlo, kahoo e fokotsa ho omella le ho teneha.

Ntle le ts'ebeliso ea eona ho li-ophthalmic formulations, CMC e boetse e sebelisoa litlhare tse ling tsa molomo ho ntlafatsa sekhahla sa ho qhibiliha le ho qhibiliha ha tsona. CMC ka sebelisoa e le disintegrant ka matlapa a, ho ba thusa ho senya ka potlako ho feta pampitšana gastrointestinal le ho ntlafatsa bioavailability ea motsoako o sebetsang. CMC e ka boela ea sebelisoa e le setlamo sa letlapa le li-capsule formulations, e thusang ho tšoara metsoako e sebetsang hammoho le ho ntlafatsa ho hatelloa ha tsona.

CMC ke mothusi ea amoheloang ka bophara indastering ea meriana 'me e laoloa ke mekhatlo e fapaneng ea taolo ea lithethefatsi lefatšeng ka bophara. United States, FDA (Tsamaiso ea Lijo le Lithethefatsi) e laola CMC e le motsoako oa lijo le e le motsoako o sa sebetseng oa lithethefatsi. FDA e thehile lintlha tsa boleng le bohloeki ba CMC e sebelisoang meriana 'me e behile maemo a mangata bakeng sa litšila le lihlapolli tse setseng.

European Union, CMC e laoloa ke European Pharmacopoeia (Ph. Eur.) 'me e kenyelelitsoe lethathamong la li-excipients tse ka sebelisoang lihlahisoa tsa meriana. The Ph. Eur. e boetse e thehile lintlha tsa boleng le bohloeki ba CMC e sebelisoang meriana, ho kenyelletsa le meeli ea litšila, litšepe tse boima, le lihlapolli tse setseng.

Ka kakaretso, CMC e bapala karolo ea bohlokoa mekhoeng e mengata ea meriana mme e sebelisoa lits'ebetsong tse fapaneng tsa kalafo. Botenya ba eona bo khabane, bo tsitsisa, le ho tlotsa, bo etsa hore e be motsoako o fapaneng o ka sebelisoang mefuteng e mengata e fapaneng. Joaloka motsoako o laoloang, lik'hamphani tsa meriana li ka itšetleha ka CMC hore e bolokehe, e sebetse hantle, 'me e be ea boleng bo phahameng mekhoeng ea bona.