Cellulose ethers ke sehlopha sa li-polymer tse fetotsoeng tse thehiloeng ho selulose, tse sebelisoang haholo indastering ea meriana ka lebaka la thepa ea tsona e ntle ea 'mele le ea lik'hemik'hale. Mefuta ea eona ea mantlha e kenyelletsa hydroxypropyl methylcellulose (HPMC), carboxymethyl cellulose (CMC) le methyl cellulose (MC). Li-ethers tsena tsa cellulose li na le mefuta e mengata ea litšebeliso ho meriana, matlapa a koahelang, li-capsules, litokisetso tsa ho lokolloa ka mokhoa o tsitsitseng le litokisetso tsa metsi.
1. Kopo ka matlapa le li-capsules
Litokisetsong tsa letlapa le capsule, li-cellulose ethers li atisa ho sebelisoa e le li-binders, disintegrants le lisebelisoa tsa ho roala. Joaloka li-binders, li ka ntlafatsa ho khomarela pakeng tsa likaroloana tsa lithethefatsi, e le hore matlapa a thehe sebopeho se tiileng se nang le boima bo loketseng le nako ea ho arohana. Li-cellulose ethers li ka boela tsa ntlafatsa mokelikeli le ho hatelloa ha lithethefatsi le ho khothalletsa ho bōptjoa ho tšoanang.
Li-binders: Ka mohlala, HPMC e le setlamo se ka ajoa ka mokhoa o ts'oanang holim'a likaroloana tsa lithethefatsi, ho fana ka ho khomarela ho ts'oanang ho tiisa hore matlapa a boloka sebopeho se tsitsitseng nakong ea khatello.
Li-Disintegrants: Ha li-cellulose ethers li ruruha ka metsing, li ka eketsa ka katleho lebelo la ho senyeha ha matlapa le ho etsa bonnete ba ho lokolloa ha lithethefatsi ka potlako. MC le CMC, joalo ka li-disintegrants, li ka potlakisa ho arohana ha matlapa ka har'a pampitšana ea mala le ho ntlafatsa bioavailability ea lithethefatsi ka thepa ea bona ea hydrophilicity le ho ruruha.
Lisebelisoa tsa ho roala: Li-cellulose ethers tse kang HPMC le tsona li sebelisoa hangata bakeng sa ho roala matlapa le li-capsules. Lera la ho roala le ke ke la pata tatso e mpe ea lithethefatsi feela, empa hape le fana ka lera le sireletsang ho fokotsa tšusumetso ea mongobo oa tikoloho ho tsitsitseng ha lithethefatsi.
2. Kopo litokisetsong tsa tokollo e tsitsitseng
Li-cellulose ethers li phetha karolo ea bohlokoa litokisetsong tsa tokollo e tsitsitseng 'me li sebelisoa haholo-holo ho laola sekhahla sa ho lokolloa ha lithethefatsi. Ka ho fetola mofuta, viscosity le mahloriso a li-cellulose ethers, litsebi tsa meriana li ka etsa li-curve tse fapaneng tsa ho lokolloa ha lithethefatsi ho finyella ho lieha ho lokolloa, ho lokolloa ho laoloang kapa tokollo e lebisitsoeng.
Lisebelisoa tse laoloang tsa tokollo: Li-ether tsa cellulose tse kang HPMC le EC (ethyl cellulose) li sebelisoa e le lisebelisoa tse laoloang tsa tokollo matlapeng a tsoelang pele a lokolloa. Ba ka qhibiliha butle-butle 'meleng ho etsa lera la gel, kahoo ba laola sekhahla sa ho lokolloa ha moriana le ho boloka motsoako oa plasma oa moriana.
Lisebelisoa tsa skeleton: Litokisetsong tsa skeleton tse tsoelang pele, li-cellulose ethers li hasanya lithethefatsi ka har'a matrix ka ho etsa sebopeho sa marang-rang ho lokisa sekhahla sa ho qhibiliha ha lithethefatsi. Ka mohlala, lisebelisoa tsa skeleton tsa HPMC li etsa li-gel ha li pepesehile metsing, li thibela ho felisoa ka potlako ha lithethefatsi le ho finyella taolo ea nako e telele.
3. Kopo ka litokisetso tsa metsi
Li-cellulose ethers li sebelisoa haholo e le li-thickeners, li-suspending agents le li-stabilizers litokisetsong tsa metsi. Li ka eketsa viscosity le botsitso ba litokisetso tsa mokelikeli le ho thibela moriana hore o se ke oa lula kapa oa stratifying nakong ea polokelo.
Thickeners: Cellulose ethers (joaloka CMC) joalo ka li-thickeners li ka eketsa viscosity ea litokisetso tsa mokelikeli, tsa netefatsa kabo e tšoanang ea metsoako ea lithethefatsi, le ho thibela ho na ha lithethefatsi.
Li-suspending agents: HPMC le MC li sebelisoa e le lisebelisoa tse emisang litokisetso tsa metsi ho etsa bonnete ba hore likaroloana tse emisitsoeng li ajoa ka mokhoa o lekanang nakong eohle ea ho lokisetsa ka ho etsa mokhoa o tsitsitseng oa colloidal ho thibela ho arohana ha metsoako ea lithethefatsi.
Li-stabilizers: Li-cellulose ethers li ka boela tsa sebelisoa e le li-stabilizers ho ntlafatsa botsitso ba lik'hemik'hale le 'meleng oa litokisetso tsa metsi nakong ea polokelo le ho lelefatsa nako ea bophelo ba lithethefatsi.
4. Lisebelisoa tse ling
Ho phaella moo, li-cellulose ethers li boetse li sebelisoa litokisetsong tsa transdermal le litokisetso tsa ophthalmic indastering ea meriana. Ba sebetsa joalo ka baetsi ba lifilimi le ba ntlafatsang viscosity lits'ebetsong tsena ho ntlafatsa ho khomarela le bioavailability ea litokisetso.
Litokisetso tsa Transdermal: HPMC le CMC hangata li sebelisoa e le baetsi ba lifilimi bakeng sa li-patches tsa transdermal, tse ntlafatsang ho monya ha lithethefatsi ka ho laola ho tsoa mouoane ha metsi le sekhahla sa ho kenella ha lithethefatsi.
Litokisetso tsa mahlo: Litokisetsong tsa mahlo, li-cellulose ethers li sebelisoa e le li-thickeners ho ntlafatsa ho khomarela meriana ea mahlo, ho lelefatsa nako ea ho lula ha lithethefatsi sebakeng sa mahlo, le ho ntlafatsa phello ea phekolo.
Tšebeliso e pharaletseng ea li-cellulose ethers indastering ea meriana e bakoa ke thepa ea bona e ntle ea 'mele le ea lik'hemik'hale, tse kang biocompatibility e ntle, solubility e laoloang le ho feto-fetoha ha maemo ho finyella litlhoko tsa litokisetso tse fapaneng. Ka ho khetha le ho ntlafatsa li-cellulose ethers, lik'hamphani tsa meriana li ka ntlafatsa boleng le botsitso ba litokisetso tsa lithethefatsi le ho fihlela litlhoko tsa bakuli bakeng sa polokeho le katleho ea lithethefatsi. Ka tsoelo-pele e tsoelang pele ea theknoloji ea meriana, menyetla ea tšebeliso ea li-cellulose ethers e tla ba e pharaletseng.
Nako ea poso: Jul-12-2024