Ka tlhokomeliso e ntseng e eketseha ea lefats'e ea ts'ireletso ea tikoloho le tlhokahalo ea nts'etsopele ea moshoelella, indasteri ea meriana e ntse e batla ka mafolofolo litharollo tse ling tsa tikoloho le tse tšoarellang. Li-derivatives tsa cellulose ether butle-butle li fetoha e 'ngoe ea lisebelisoa tsa bohlokoa ho khothalletsa tsoelo-pele e tsitsitseng ea indasteri ea meriana ka lebaka la lisebelisoa tsa bona tsa tlhaho tse nchafalitsoeng le litšobotsi tse ka senyehang.
1. Tlhaloso ea Motheo ea Cellulose Ethers
Cellulose ethers ke lisebelisoa tsa polymer tse fumanoang ka phetoho ea lik'hemik'hale tsa cellulose ea tlhaho. Cellulose e fumanoa haholo limela, tse kang k'hothone le lehong. Mohloli oa eona ke ketane ea polysaccharide e entsoeng ke li-unit tsa tsoekere tse hokahantsoeng ke li-bond tsa β-1,4-glycosidic. Ka karabelo ea etherification, lihlopha tsa hydroxyl tsa selulose li kopantsoe le mefuta e fapaneng ea lihlopha tsa ether ho hlahisa letoto la lintho tse nkiloeng ho cellulose, joalo ka hydroxypropyl methylcellulose (HPMC), methyl cellulose (MC) le hydroxyethyl cellulose (HEC). Li-derivatives tsena tsa cellulose ether li na le mokhoa o babatsehang oa ho etsa lifilimi, ho khomarela, ho teteaneng le ho tsitsisa mocheso, 'me li sebelisoa haholo meriana, kaho, lijo, litlolo le liindasteri tse ling.
2. Tšebeliso ea li-derivatives tsa cellulose ether indastering ea meriana
Bajari ba lithethefatsi le litsamaiso tsa tokollo e tšoarellang
E 'ngoe ea lisebelisoa tse sebelisoang ka ho fetisisa tsa li-derivatives tsa cellulose ether litokisetsong tsa meriana ke thepa ea thepa le thepa e sa khaotseng bakeng sa lithethefatsi. Ka thepa ea eona ea ho etsa lifilimi le ho khomarela, li-cellulose ethers li ka sebelisoa ho lokisetsa matlapa a meriana, li-capsules le lifilimi. Haholo-holo, lits'ebetsong tse sa khaotseng tsa tokollo, li-derivatives tsa cellulose tse kang HPMC li ka etsa lera la gel ka mor'a hydration, butle-butle li lokolla metsoako ea lithethefatsi, 'me li netefatse ho kenngoa butle-butle le ho tsoelang pele ha lithethefatsi' meleng. Theknoloji ena e tsoelang pele ea tokollo e ke ke ea ntlafatsa bioavailability ea lithethefatsi feela, empa hape e fokotsa khafetsa ea meriana le ho fokotsa moroalo ho bakuli.
Li-binders tsa matlapa le li-disintegrants
Tlhahisong ea matlapa, li-derivatives tsa cellulose ether li boetse li sebelisoa haholo e le li-binders le disintegrants. Joaloka setlamo, cellulose ether e ka eketsa matla a ho kopanya pakeng tsa likaroloana tsa phofo ha matlapa a hatelloa, ho netefatsa matla le botsitso ba matlapa; e le ntho e senyang, e ka potlakela ho monya metsi le ho ruruha ka mor'a ho kopana le metsi, ho lumella matlapa hore a qhalane ka potlako le ho qhibiliha tsamaisong ea tšilo ea lijo, kahoo a eketsa lebelo la ho lokolloa le ho monya hantle ha lithethefatsi.
Litokisetso tsa batsoali
Li-derivatives tsa cellulose ether li boetse li sebelisetsoa ho lokisetsa litokisetso tsa batsoali, tse kang li-viscosity regulators le stabilizers ka lithethefatsi tse kenang methapong. Lintho tsa eona tse ikhethang tsa 'mele le lik'hemik'hale li etsa hore e tsitse ka mor'a ho thibela ho thibela mocheso o phahameng ntle le ho ama ts'ebetso ea likokoana-hloko ea moriana. Ka nako e ts'oanang, ho se be chefo le biocompatibility ea cellulose ethers le tsona li netefatsa polokeho ea eona 'meleng.
3. Tlatsetso ea li-derivatives tsa cellulose ether ho ts'ebetsong ea indasteri ea meriana.
E tsoa mehloling ea tlhaho, e ka nchafatsoang
Monyetla o moholo oa li-derivatives tsa cellulose ke hore li tsoa mehloling ea tlhaho e nchafalitsoeng e kang k'hothone le lehong. Sena se fapane haholo le li-polymer tsa setso tsa maiketsetso (joalo ka polyethylene, polypropylene, joalo-joalo). Lisebelisoa tsa setso tsa maiketsetso li atisa ho itšetleha ka lihlahisoa tsa petrochemical, tse lebisang ho sebelisoa ho feteletseng ha lisebelisoa tse sa tsosolositsoeng le mathata a tšilafalo ea tikoloho. Ka lehlakoreng le leng, cellulose, joalo ka lintho tse thehiloeng ho bioloji, e ka fanoa khafetsa ka potoloho ea kholo ea limela, ho fokotsa ho itšetleha ka lisebelisoa tsa petrochemical.
Biodegradable, ho fokotsa tšilafalo ea tikoloho
Molemo o mong o moholo oa lintho tse tsoang ho cellulose ether ke hore li na le biodegradability e ntle. Ho fapana le lipolasetiki tsa setso le thepa ea maiketsetso, li-cellulose ethers li ka bola ke likokoana-hloko tse phelang tikolohong ea tlhaho ’me qetellong li hlahise lintho tse se nang kotsi tse kang metsi le carbon dioxide. Sena se fokotsa haholo tšusumetso e mpe ea litšila tikolohong nakong ea tlhahiso ea meriana le ho thusa ho fokotsa tšilafalo ea mobu le metsi ka litšila tse tiileng.
Ho boloka matla le phokotso ea khabone
Ts'ebetso ea tlhahiso ea li-cellulose ethers e batla e le tlase tšebelisong ea matla, 'me phetoho ea lik'hemik'hale le ts'ebetso ea lik'hemik'hale li ka finyelloa ka mocheso o tlaase, e leng se fapaneng haholo le ts'ebetso e phahameng ea tlhahiso ea matla a matla a li-polymer tse ling tsa maiketsetso. Ka nako e ts'oanang, ka lebaka la litšobotsi tse bobebe tsa thepa e thehiloeng ho cellulose, li ka boela tsa fokotsa tšebeliso ea matla le ho tsoa ha carbon nakong ea lipalangoang le ho paka.
Melao-motheo ea k'hemistri e tala
The synthesis process of cellulose ether derivatives ka latela melao-motheo ea k'hemistri e tala, ke hore, ka ho fokotsa tšebeliso ea li-reagents tse kotsi tsa lik'hemik'hale le ho ntlafatsa maemo a itšoarang ho fokotsa tlhahiso ea lihlahisoa, kahoo ho fokotsa tšusumetso ea tikoloho. Ka mohlala, mokhoa oa ho hlahisa li-cellulose ethers tsa morao-rao o amohetse mekhoa e mengata ea ho qhibilihisa e sa silafatseng tikoloho, e fokolitseng haholo ho ntšoa ha litšila tse chefo.
4. Pono ea Bokamoso
Ka nts'etsopele e tsoelang pele ea meriana e tala, menyetla ea ts'ebeliso ea lihlahisoa tsa cellulose ether indastering ea meriana e tla ba e pharaletseng. Ntle le ts'ebeliso ea eona ho litokisetso tse tiileng le mekhoa e tsitsitseng ea ho lokolloa, li-cellulose ethers li tla boela li phethe karolo e kholo ho mekhoa e mecha ea ho fana ka lithethefatsi, lisebelisoa tsa biomedical le masimo a mang. Ho phaella moo, ka tsoelo-pele e tsoelang pele ea thekenoloji e tsoang ho cellulose derivative synthesis, nts'etsopele ea mekhoa ea ho lokisa e sebetsang hantle le e theko e tlaase e tla tsoela pele ho khothalletsa botumo ba eona indastering ea meriana.
Indasteri ea meriana e tla ela hloko haholo ts'ebeliso ea lisebelisoa tsa tikoloho, le lihlahisoa tsa cellulose ether, e le lisebelisoa tse nchafalitsoeng, tse senyehang le tse nang le mesebetsi e mengata, ntle ho pelaelo li tla phetha karolo ea bohlokoa ts'ebetsong ena ea phetoho.
Li-derivatives tsa cellulose ether li ntlafalitse haholo ts'ebetso ea indasteri ea meriana ka ho nchafatsoa ha tsona, biodegradability le ts'ebeliso e pharaletseng ea tlhahiso ea meriana. Ha li fokotse feela ho itšetleha ka lisebelisoa tse sa tsosolosoeng, empa hape li fana ka liphallelo tsa bohlokoa ho sireletsa tikoloho. Li-derivatives tsa cellulose ether li lebeletsoe hore li tsoele pele ho phetha karolo ea bohlokoa nakong e tlang ea tlhahiso ea meriana e tala le nts'etsopele e tsitsitseng.
Nako ea poso: Sep-23-2024