Capsule Grade HPMC bakeng sa Kopo ea Pharma

Hydroxypropyl methylcellulose (HPMC) ke polymer e feto-fetohang e sebelisoang haholo indastering ea meriana ka lebaka la thepa ea eona e ikhethang e kang ho qhibiliha ho hoholo, ho lumellana ha lintho le ho se chefo. Capsule grade HPMC, eo hape e tsejoang e le hypromellose, e etselitsoe ho sebelisoa likhetla tsa capsule tsa meriana. Sehloohong sena, re tla tšohla thepa, tlhahiso, le ts'ebeliso ea "capsule grade HPMC".

Thepa ea Capsule Grade HPMC

Capsule grade HPMC ke semi-synthetic, inert, le metsi-soluble polymer e nkiloeng ho selulose. Ke phofo e tsoeu ho isa ho e tšoeu e sa nkheng, e sa latsoeheng, 'me e phalla ka bolokolohi. Lintho tse ka sehloohong tsa HPMC ea capsule grade ke:

High solubility: Capsule grade HPMC e qhibiliha habonolo ka metsing ebe e etsa tharollo e hlakileng. E na le mocheso o tlaase oa gelation, e bolelang hore e ka etsa li-gel ka mocheso o tlaase.

Non-toxicity: Capsule grade HPMC ke polima e seng chefo e bolokehileng bakeng sa ho sebelisoa ke batho. E boetse e amohetsoe ke mekhatlo e fapaneng ea taolo e joalo ka US FDA, European Pharmacopoeia, le Japanese Pharmacopoeia.

Biocompatibility: Capsule grade HPMC e lumellana le mekhoa ea likokoana-hloko 'me ha e bake liphello tse mpe bophelong ba motho.

pH botsitso: Capsule grade HPMC e tsitsitse ka mefuta e mengata ea pH ea boleng, e etsang hore e loketse ho sebelisoa libakeng tse nang le acidic, neutral, le tsa motheo.

Thepa ea ho etsa lifilimi: Capsule grade HPMC e ka etsa filimi e matla le e tenyetsehang e sa khoneng ho petsoha, ho ebola le ho robeha.

Thepa ea tokollo e laoloang: Capsule grade HPMC e ka sebelisoa ho laola ho lokolloa ha lithethefatsi ho khetla ea capsule, e leng se etsang hore e be molemo bakeng sa ho hlahisa litlhare tsa nako e telele.

Ho etsoa ha Capsule Grade HPMC

Capsule grade HPMC e hlahisoa ka ho fetola lik'hemik'hale cellulose ea tlhaho ka propylene oxide le methyl chloride. The degree of substitution (DS) ea HPMC e ipapisitse le karo-karolelano ea propylene oxide ho methyl chloride e sebelisitsoeng karabelong. Boleng ba DS bo bontša palo ea lihlopha tsa hydroxyl tse selulose tse nketsoeng sebaka ke lihlopha tsa hydroxypropyl le methyl.

Capsule grade HPMC e fumaneha ka limaraka tse fapaneng, ho ipapisitse le viscosity ea eona le tekanyo ea ho e nkela sebaka. The viscosity ea HPMC ke tekanyo ea boima ba molek'hule le tekanyo ea polymerization. Ha viscosity e phahame, boima ba molek'hule bo phahame 'me tharollo e ba e tenya. Tekanyo ea ho kenya sebaka e lekanya ho solubility le gelation thepa ea HPMC.

Likopo tsa Capsule Grade HPMC

Capsule grade HPMC e sebelisoa haholo indastering ea meriana bakeng sa ho etsa likhetla tsa capsule. Likhetla tsa capsule li sebelisetsoa ho koahela lintho tsa lithethefatsi le ho fana ka mokhoa o bonolo le o sireletsehileng oa ho isa lithethefatsi ho bakuli. Lisebelisoa tsa mantlha tsa "capsule grade HPMC" indastering ea meriana ke:

Li-capsules tsa Vegetarian: Capsule grade HPMC ke mokhoa o tloaelehileng oa ho sebelisa li-gelatin capsules, tse nkiloeng mehloling ea liphoofolo. Li-capsules tsa Vegetarian tse entsoeng ho tloha HPMC li loketse ho sebelisoa ka lihlahisoa tsa limela le tsa meroho 'me li na le mongobo o fokolang, o etsang hore li tsitse le ho li tšoara habonolo.

Litlhahiso tsa tokollo e laoloang: Capsule grade HPMC e ka sebelisoa ho laola ho lokolloa ha lithethefatsi ho tloha khetla ea capsule. Sekhahla sa ho lokolloa ha lithethefatsi se ka laoloa ka ho lokisa viscosity le tekanyo ea ho kenya sebaka sa HPMC. Sena se etsa hore capsule grade HPMC e be le thuso bakeng sa ho etsa litlhare tsa nako e telele tse ka fanang ka phepelo e tsitsitseng ea lithethefatsi ka nako e telele.

Li-capsules tse koahetsoeng ka Enteric: Capsule grade HPMC e ka sebelisoa ho etsa li-capsules tse koahetsoeng ke enteric, tse etselitsoeng ho lokolla moriana ka maleng ho e-na le ka mpeng. Li-capsules tse koahetsoeng ka Enteric li na le thuso bakeng sa lithethefatsi tse utloisisang tikoloho ea acidic ea mpa kapa tse bakang ho teneha lesela la mpa.

Taste-masking: Capsule grade HPMC e ka sebelisoa ho pata tatso e babang ea lithethefatsi tse nang le tatso e sa thabiseng. HPMC e ka sebelisoa ho etsa setlolo se koahelang tatso holim'a likaroloana tsa lithethefatsi, se ka ntlafatsang boikamahanyo le kamohelo ea mokuli.

Ntlafatso ea Solubility: Capsule grade HPMC e ka ntlafatsa ho qhibiliha ha lithethefatsi tse sa qhibiliheng hantle ka ho theha phallo e tiileng. HPMC e ka sebelisoa ho koahela likaroloana tsa lithethefatsi le ho ntlafatsa thepa ea tsona ea ho koloba le ho qhibiliha.

Excipient: Capsule grade HPMC e ka sebelisoa e le excipient mefuteng e sa tšoaneng ea meriana e kang matlapa, litlolo, le ho emisoa. E ka sebetsa e le se tlamellang, se senyang, sa emulsifier, le stabilizer, ho itšetlehile ka sebopeho.

Qetello

Capsule grade HPMC ke polymer e feto-fetohang le e sebelisoang haholo indastering ea meriana. E na le thepa e ikhethang e kang ho qhibiliha ho hoholo, ho se chefo, le biocompatibility, e leng se etsang hore e be thepa e loketseng ho sebelisoa likhetla tsa capsule. Mokhoa oa ho etsa li-capsule grade HPMC o kenyelletsa ho fetola lik'hemik'hale cellulose ea tlhaho ka propylene oxide le methyl chloride ho fumana viscosity e lakatsehang le tekanyo ea ho fetola. Capsule grade HPMC e fumana lisebelisoa tse fapaneng indastering ea meriana, joalo ka ha ho etsoa li-capsules tsa meroho, li-capsules tse laoloang, li-capsules tse koahetsoeng ke enteric, ho pata tatso, ho ntlafatsa ho qhibiliha, le ho thusa ho hlahisa mefuta e sa tšoaneng.