HPMC K4M (hydroxypropyl methylcellulose K4M) ke motsoako o tloaelehileng oa meriana o sebelisoang haholo indastering ea meriana, haholo-holo matlapa a lokolotsoeng ka mokhoa o tsitsitseng, litokisetso tse laoloang-ho lokolloa le litokisetso tse ling tse tiileng tsa molomo.
Lintho tsa motheo tsa HPMC K4M
HPMC K4M ke kereiti e tloaelehileng ea Hydroxypropyl Methylcellulose (HPMC). HPMC ke semi-synthetic, high molecular weight multifunctional polymer material e entsoeng ka selulose e fetotsoeng ka lik'hemik'hale e nang le thepa e ntle ea 'mele le ea lik'hemik'hale, e kang ho teteaneng ho hoholo, gelling, ho etsa filimi le thepa ea ho khomarela.
HPMC K4M e sebelisoa haholo lefapheng la meriana ka lebaka la viscosity ea eona e bohareng le thepa e babatsehang ea ho tenya le ho etsa lifilimi. "K" ho K4M e emetse cellulose e phahameng ea viscosity, 'me "4M" e bolela hore viscosity ea eona e ka bang 4000 centipoise (e lekantsoeng ka 2% ea tharollo ea metsi).
Lisebelisoa tsa mantlha tsa HPMC K4M indastering ea meriana
1. Kopo litokisetsong tsa tokollo e tsitsitseng
Mosebetsi o ka sehloohong oa HPMC K4M litokisetsong tsa tokollo e tsitsitseng ke ho sebetsa e le thepa ea matrix e laoloang. Bokhoni ba eona bo ikhethang ba hydrophilicity le ho etsa li-gel bo e etsa hore e be e 'ngoe ea lisebelisoa tse sebelisoang hangata lits'ebetsong tsa tokollo e tsoelang pele ea lithethefatsi. HPMC K4M e ka monya metsi ka potlako le ho ruruha ha e kopana le metsi, 'me ea etsa lera la gel holim'a letlapa, e liehisa sekhahla sa ho lokolloa ha moriana, kahoo e finyella phello e laoloang ea tokollo.
Thepa ena e loketse ka ho khetheha bakeng sa matlapa a sa khaotseng a molomo, joalo ka lithethefatsi tse thibelang khatello ea maikutlo, lithethefatsi tse thibelang lefu la tsoekere le li-analgesics. Ka ho sebelisa HPMC K4M, moriana o ka tsoela pele ho lokolloa 'meleng, ho boloka khatello ea meriana ea mali kamehla, ho fokotsa makhetlo a meriana, le ho ntlafatsa ho latela melao ea mokuli.
2. Li-capsules le lisebelisoa tsa ho roala
HPMC K4M, e le thepa ea ho roala, e ka etsa filimi e sireletsang holim'a ho lokisetsa. Filimi e na le thepa e ntle ea thibelo, e ka thibelang lithethefatsi ka katleho hore e se ke ea senyeha ke mongobo, oxidation kapa leseli, le ho lelefatsa botsitso le sethala sa bophelo ba lithethefatsi. Ho fapana le gelatin ea setso, HPMC e tsoa ho limela, kahoo e loketse batho ba jang meroho le bakuli ba sa lumellaneng le metsoako e entsoeng ke liphoofolo.
HPMC K4M e ka boela ea sebelisoa e le thepa ea ho lokisetsa likhetla tsa capsule, ho fetola li-capsules tsa gelatin, 'me e sebelisoa ho kenya li-capsules tsa meroho le lithethefatsi tse bonolo, tse nang le biocompatibility e ntle le polokeho.
3. E le motenya le setlamo
Lefapheng la meriana, HPMC K4M e sebelisoa haholo mekhoeng ea granulation ea metsi e le setlamo sa ho khothalletsa ho thehoa ha likaroloana. Thepa ea eona e babatsehang ea ho kopanya e ka etsa bonnete ba hore likaroloana li na le boima bo botle le ho arohana, ho etsa bonnete ba hore matlapa a ka senya kapele 'me a lokolla lithethefatsi ha a nkoa. Ho phaella moo, HPMC K4M ka boela sebelisoa e le thickener ka litokisetso mokelikeli, tse kang suspensions le litokisetso ophthalmic, ho eketsa viscosity le botsitso ba litokisetso.
4. Stabilizer le moemeli ea sireletsang
HPMC K4M e ka sebetsa e le stabilizer le moemeli ea sireletsang litokisetsong tse ling, haholo-holo tsamaisong ea multiphase e kang emulsions le suspensions. Bokhoni ba eona bo botenya le ba ho etsa li-gel bo ka thibela sethethefatsi hore se se ke sa tsitsa kapa sa stratify nakong ea polokelo, ho netefatsa ho ts'oana le botsitso ba tokiso. Ho phaella moo, lithethefatsing tse ling tsa likokoana-hloko kapa lithethefatsi tsa protheine, HPMC K4M e ka sebelisoa e le ntho e sireletsang ho thibela protheine hore e se ke ea senyeha kapa ea senyeha nakong ea ho itokisa kapa ho e boloka, ho netefatsa ts'ebetso ea likokoana-hloko ea lithethefatsi.
5. Mucosal absorption enhancer
Lilemong tsa morao tjena, liphuputso li bontšitse hore HPMC K4M e ka sebelisoa e le ntho e matlafatsang mucosal ea ho monya ho thusa ho ntlafatsa bioavailability ea lithethefatsi tse ling tse thata ho li monya. Ka mohlala, ka ho kopana le HPMC K4M, lithethefatsi tse itseng tsa protheine le peptide li ka kenngoa hamolemo libakeng tsa mucosal tse kang molomo oa molomo, lesapo la nko kapa rectum, ho qoba tsela ea setso ea ente le ho fana ka mokhoa o bonolo le o sa hlaselehang oa tsamaiso.
6. Mosebetsi oa ho laola ho lokolloa ha lithethefatsi
HPMC K4M e ke ke ea sebelisoa feela e le mokhoa o le mong o laoloang oa tokollo, empa hape e ka sebelisoa hammoho le lisebelisoa tse ling tse laoloang tsa tokollo (tse kang carbomer, ethyl cellulose, joalo-joalo) ho laola ka mokhoa o ts'oanang ho laola ho lokolloa ha lithethefatsi. Ka ho fetola mahloriso, boima ba limolek'hule kapa karo-karolelano ea HPMC K4M le li-excipients tse ling, lienjineri tsa tšebetso ea meriana li ka fetola ka nepo sekhahla sa tokollo ea lithethefatsi ho fihlela litlhoko tsa kalafo tsa lithethefatsi tse fapaneng.
Melemo ea HPMC K4M ka meriana
Tšireletseho e ntle le biocompatibility: HPMC K4M ke ntho e se nang chefo, e sa hloekiseng, 'me mohloli oa eona ke cellulose ea tlhaho, e loketseng ho sebelisoa nako e telele. Kaha HPMC K4M ha e itšetlehe ka ho senyeha ha enzyme ea mala, tsela ea eona ea metabolic 'meleng e bonolo haholo, e fokotsa kotsi e ka bang teng ea litla-morao.
Ho bonolo ho e sebelisa: HPMC K4M e ka qhibiliha ka metsing a batang le a chesang, 'me tharollo e na le botsitso bo botle' me e bonolo ho e sebelisa. Bokhoni ba eona ba ho etsa lifilimi le ho etsa li-gel bo e fa mokhoa o motle oa ho ikamahanya le maemo ts'ebetsong ea meriana.
Mefuta e mengata ea likopo: HPMC K4M ha e loketse feela bakeng sa litokisetso tse tiileng tsa molomo, empa hape le mefuta e fapaneng ea litekanyetso tse ling, tse kang litokisetso tsa lihlooho, litokisetso tsa mahlo, liente le litokisetso tsa ho inhalation.
Joalo ka mothusi oa meriana ea sebetsang ka bongata, HPMC K4M e na le boemo ba bohlokoa indastering ea meriana ka thepa ea eona e ntle ea 'mele le ea lik'hemik'hale le maemo a fapaneng a ts'ebeliso. E na le phello e kholo lintlheng tse ngata tse kang litokisetso tsa ho lokolloa ka mokhoa o tsitsitseng, li-thickeners, lisebelisoa tsa ho roala, li-stabilizer, joalo-joalo, haholo-holo bakeng sa ho lokisoa ha matlapa a lokolloang ka molomo, e na le melemo e ke keng ea lekanngoa. Ka tsoelo-pele e tsoelang pele ea theknoloji ea meriana, litebello tsa tšebeliso ea HPMC K4M li tla ba tse pharaletseng, 'me boemo ba eona litokisetsong tse ncha tsa meriana bo tla tsoela pele ho ntlafala.
Nako ea poso: Sep-29-2024