HPMC (Hydroxypropyl Methylcellulose) waa maaddooyin kala duwan oo si weyn loogu isticmaalo dawooyinka, cuntada, qalabka dhismaha iyo meelaha kale. Alaabooyinka HPMC waxaa loo qaybin karaa taxane badan iyadoo loo eegayo shuruudaha dalabka ee kala duwan, kuwaas oo kuwa ugu caansan ay yihiin taxanaha K iyo taxanaha E. Inkasta oo labaduba ay yihiin HPMC, waxay leeyihiin farqi gaar ah oo ku saabsan qaab dhismeedka kiimikada, sifooyinka jirka iyo goobaha codsiga.
1. Farqiga u dhexeeya qaab-dhismeedka kiimikada
Mawduucyada Methoxy: Farqiga ugu weyn ee u dhexeeya taxanaha K iyo taxanaha E HPMC waa maadada hab-raaca. Mawduuca methoxy ee taxanaha E HPMC wuu sarreeyaa (guud ahaan 28-30%), halka maadada methoxy ee taxanaha K ay aad u hooseyso (qiyaastii 19-24%).
Waxyaabaha Hydroxypropoxy: Taas beddelkeeda, waxa ku jira hydroxypropoxy ee taxanaha K (7-12%) ayaa ka sarreeya ta taxanaha E (4-7.5%). Farqiga u dhexeeya halabuurka kiimikaad wuxuu keenaa kala duwanaanshiyaha waxqabadka iyo adeegsiga labada.
2. Kala duwanaanshiyaha guryaha
Solubility: Sababo la xiriira kala duwanaanshaha methoxy iyo hydroxypropoxy content, solubility ee taxanaha K HPMC wax yar ka hooseeya ta taxanaha E, gaar ahaan biyaha qabow. Taxanaha E wuxuu aad ugu milmay biyaha qabow sababtoo ah maadada methoxy ee sare.
Heerkulka jel: Heerkulka jel ee taxanaha K wuu ka sarreeyaa ta taxanaha E. Tani waxay ka dhigan tahay in isla shuruudo la mid ah, ay aad ugu adag tahay K taxanaha HPMC inuu sameeyo jel. Heerkulka jel ee taxanaha E wuu hooseeyaa, iyo codsiyada gaarka ah qaarkood, sida walxaha jelka heerkulbeegga, taxanaha E ayaa laga yaabaa inuu si fiican u qabto.
Viscosity: Inkasta oo viscosity inta badan ay ku xiran tahay miisaanka kelli ee HPMC, isla shuruudo la mid ah, viscosity ee taxanaha E HPMC inta badan wuu ka sarreeyaa taxanaha K. Farqiga u dhexeeya viscosity ayaa saameyn weyn ku leh sifooyinka rheological inta lagu jiro habka diyaarinta, gaar ahaan marka lagu dabaqo daboolka iyo joojinta.
3. Kala duwanaanshaha goobaha codsiga
Sababo la xiriira kala duwanaanshaha qaab dhismeedka kiimikada iyo sifooyinka jirka ee taxanaha K iyo taxanaha E HPMC, codsiyadooda meelo kala duwan ayaa sidoo kale ka duwan.
Goobta dawooyinka: Diyaargarowga dawooyinka, taxanaha E HPMC waxaa badanaa loo isticmaalaa sida walxaha ugu muhiimsan ee diyaarinta sii-deynta joogtada ah. Tani waxay sabab u tahay heerkulka gelation hoose iyo viscosity sare, taas oo u sahlaysa in ay si fiican u xakameeyo heerka sii daayo daroogada marka la samaynayo daroogada sii daayo-sii daayo filim. Taxanaha K waxaa aad loogu isticmaalaa kiniinnada dahaarka leh iyo sida walxaha gidaarka kaabsoosha, sababtoo ah heerkulkeeda sare ee gelation waxay joojisaa sii deynta daroogada ee casiirka gastric, taas oo u sahlaysa in la sii daayo daawooyinka xiidmaha.
Goobta cuntada: Warshadaha cuntada, taxanaha E HPMC waxaa badanaa loo isticmaalaa dhumuc weyn, dejiye iyo emulsifier ahaan. Sababo la xiriira milmayntiisa sare iyo viscosity habboon, si fiican ayaa loo kala firdhi karaa oo lagu milmi karaa cuntada. Taxanaha K waxaa inta badan loo isticmaalaa cuntooyinka u baahan in lagu ilaaliyo xasilloonida xaaladaha heerkulka sare, sida alaabta la dubay, sababtoo ah heerkulkiisa gelation sare.
Goobta agabka dhismaha: Agabka dhismaha, taxanaha K HPMC waxaa badanaa loo isticmaalaa hoobiye qalalan iyo budada suufka ah, oo u dhaqma sidii biyo haynta iyo dhumucyada, gaar ahaan waqtiyada u baahan in lagu dhiso heerkul sare. Taxanaha E wuxuu aad ugu habboon yahay qalabka leh sifooyinka rheological sare sida rinjiga sagxadda iyo dahaarka sababtoo ah heerkulka gelation hoose iyo viscosity sare.
4. Arrimaha kale ee saamaynta leh
Marka lagu daro kala duwanaanshaha sare, isticmaalka gaarka ah ee taxanaha kala duwan ee HPMC waxa kale oo laga yaabaa inay saameeyaan arrimo ay ka mid yihiin miisaanka kelli, heerka beddelka, iyo kala firdhisanaanta. Intaa waxaa dheer, codsiyada wax ku oolka ah, xulashada HPMC waxay sidoo kale u baahan tahay inay tixgeliso la jaanqaadkeeda maaddooyinka kale iyo saameynta ay ku leedahay waxqabadka badeecada ugu dambeysa.
Inkasta oo taxanaha K iyo taxanaha E ee HPMC ay labaduba yihiin hydroxypropyl methylcellulose, waxay muujinayaan kala duwanaansho cad oo ku saabsan guryaha jireed iyo meelaha codsiga sababtoo ah waxa ku jira kala duwan ee kooxaha methoxy iyo hydroxypropoxy. Fahamka kala duwanaanshahan ayaa muhiim u ah doorashada nooca saxda ah ee HPMC ee codsiyada la taaban karo.
Waqtiga boostada: Agoosto-13-2024