Waa maxay hypromellose phthalate?

Hypromellose phthalate (HPMCP) waa nooc ka mid ah dawooyinka dawooyinka ee loo isticmaalo samaynta foomamka qiyaasta qiyaasta afka, gaar ahaan soo saarista kaniiniyada dahaaran ee mindhicirka iyo kaabsal. Waxaa laga soo qaatay cellulose, taas oo ah polymer-dabiiciga ah oo sameeya qaybta qaab dhismeedka derbiyada unugyada dhirta. HPMCP waa biyo-milmi kara, polymer anionic kaas oo sida caadiga ah loo isticmaalo sida walxaha dahaarka galitaanka sababtoo ah sifooyinka samaynta filimada ee wanaagsan, xasiloonida, iyo caabbinta dareeraha caloosha.

HPMCP waxaa markii ugu horeysay la soo bandhigay horraantii 1970-meeyadii waxayna tan iyo markaas noqotay shay daahan oo si weyn loo isticmaalo taasoo ay ugu wacan tahay sifooyinkeeda gaarka ah. Waxaa lagu soo saaraa esterification of hypromellose leh phthalic acid waxaana lagu heli karaa heerar kala duwan oo kala duwan, taas oo ku xidhan heerka phthalation iyo miisaanka kelli ee polymer. Heerarka ugu badan ee la isticmaalo ee HPMCP waa HPMCP-55, HPMCP-50, iyo HPMCP-HP-55, kuwaas oo leh heerar kala duwan oo phthalation ah waxayna ku habboon yihiin in loo isticmaalo noocyo kala duwan oo qaabab ah.

Shaqada ugu weyn ee HPMCP ee qaababka dawooyinka ayaa ah in laga ilaaliyo maaddooyinka firfircoon ee daawada hoos u dhaca deegaanka acidic ee caloosha. Marka kiniiniga ama kaabsulka ay ku jiraan HPMCP la nuugo, dahaarka ayaa weli ah mid sax ah caloosha sababtoo ah pH hooseeya, laakiin marka qaabka qiyaasta uu gaaro jawiga alkaline ee xiidmaha yar, dahaarka wuxuu bilaabaa inuu milo oo sii daayo maaddooyinka firfircoon. Siideyntan daahday waxay gacan ka geysataa hubinta in dawada la geynayo goobta ficilka iyo in waxtarkeeda aysan wax u dhimin aashitada gastric.