Hydroxypropyl methylrcellesulose (HPMC)iyoMethylrcellulose (MC)Labada nooc ee unugyada unugyadu si caadi ah ayaa loo isticmaalaa waxyaabo kala duwan oo warshado ah, oo ay ku jiraan dawooyinka, cuntada, waxyaabaha la isku qurxiyo, iyo dhismaha. In kasta oo ay isku mid yihiin, labadan shey waxay leeyihiin guryo kiimiko ah iyo codsiyo kala duwan.
1. Qaab-dhismeedka kiimikada
Labada HPMC iyo MC-da labadaba waa astaamo keli ah, laakiin farqiga ugu muhiimsan ayaa ku jira kooxaha kiimikada ku lifaaqan laf-dhabarka laf-dhabarka.
Methylrcellulose (MC): Tan waxaa lagu sameeyay methlation ee cellulose. Hawshan, kooxaha methyl (-ch3) ayaa ku lifaaqan kooxaha hydroxyl ee molekules-ka maskaxda. Shahaadada methlation-ka ayaa caadi ahaan ku kala duwan 20-30%, iyadoo kuxiran heerka MC, taas oo saameyn ku leh xalihiisa iyo guryaha kale.
Hydroxypropyl methylrcellesulose (HPMC): Kimacel®hpmc waa mid kacsan oo cakiran. Marka lagu daro methylation, sidoo kale waxaa lagu maraa hydroxypropylation. Kooxaha hydroxypropyl (-ch2chohchch3) waxaa lagu soo bandhigayaa molecule-ka unugyada, oo ay weheliso kooxaha methyl. Shahaadada ku jirta hydroxypropylation iyo shahaadada methlation ee HPMC si weyn ayey u kala duwanaan karaan, taas oo siisa heerar kala duwan oo fasallo HPMC ah oo leh astaamo kala duwan.
| Muujinta | Methylrcellulose (MC) | Hydroxypropyl methylrcellesulose (HPMC) |
| Qaab-dhismeedka kiimikada | Methylation of cellulose | Methylation iyo hydroxypylation ee cellulose |
| Kooxaha shaqeeya | Kooxaha methyl (-ch3) | Kooxaha methyl (-ch3) + hydroxypropyl kooxaha (-ch2chohchch3) |
| Heerka beddelka (ds) | 20-30% methylation | Kala duwan, oo leh methyl iyo hydroxyplopyl beddelka ayaa la hagaajin karaa |
2. Xaraash
Xaba-qaadidu waa mid ka mid ah qodobbada ugu muhiimsan marka la barbar dhigo MC iyo HPMC. Xoolaha labada jilib ee labada nooc ee cudurka cellulose waxay kuxirantahay heerka badalka iyo qaab dhismeedka gaarka ah ee maaddada.
Methylrcellulose (MC): MC waxay ku milmaysaa biyo kulul laakiin waxay ku sameysaa jel qaboojinta. Hantidan gaarka ah ee sameynta gells markii la kululeeyo oo dib ugu laabto Dawlad dareere ah markii qaboojinta waa mid ka mid ah astaamaha ugu muhiimsan ee MC. Waa mid aan biyo qabow ku dhexjiro, laakiin ku milma biyo kulul oo ka sarreeya heerkulka heerkulka (50-70 ° C), iyo habka gelitaanka ayaa dib loo beddeli karaa.
Hydroxypropyl methylrcellesulose (HPMC): HPMC, dhinaca kale, waxay ku milmaysaa biyo qabow iyo kulul labadaba. Tani waxay ka dhigeysaa mid ka sii badan marka loo eego MC. Xoogga loo yaqaan 'HPMC' waxaa saameyn ku leh nooca beddelka (saamiga methyl si ay u hesho kooxaha hydroxypropyl) iyo heerka sawirka. Darajooyinka ka sarreysa ee darajo sare waxay u muuqdaan inay HPMC ka dhigaan HPMC oo biyo ku dhex jirta heerkulka hoose.
| Xaraash | Methylrcellulose (MC) | Hydroxypropyl methylrcellesulose (HPMC) |
| Xoolaha biyaha | Biyo kulul (kuraasta qaboojinta) | Ku milma biyaha kulul iyo qabowga labadaba |
| Hantida Getation | Waxay ka dhigan tahay jel qaboojinta | Ma abuuro gel, wali wuxuu kululaadaa dhammaan heerkulka |
3. Vecyosisto
Viscosity wuxuu door muhiim ah ka ciyaaraa codsiyo badan, gaar ahaan warshadaha dawooyinka iyo cunnada.
Methylrcellulose (MC): Maskaxda xalka Kimacell®MC waa ku-tiirsanaan leh. Muuqaalku wuxuu kordhiyaa markii la kululeeyo, oo ay soo bandhigayaan ifafaalaha gelitaanka. Heerka bedelka ayaa sidoo kale saameeya jaceylka, oo leh heerar sare oo beddelaad ah guud ahaan dhaliso viscosity.
Hydroxypropyl methylrcellesulose (HPMC): HPMC guud ahaan waxay leedahay muuqaal muuqaal ah oo isdaba joog ah marka loo eego MC. Marksion ee HPMC sidoo kale waxaa saameyn ku leh heerka bedelka, laakiin weli waa xasilloon oo dhan heerkul ballaaran oo heer sare ah. Intaa waxaa sii dheer, HPMC waxaa loo habeyn karaa si ay u yeesho fiisino kala duwan, min hooseeya ilaa sare ilaa sare, taas oo ku xidhan dalabka loogu talagalay.
| Vecyosisto | Methylrcellulose (MC) | Hydroxypropyl methylrcellesulose (HPMC) |
| Dhaqanka viscosity | Waxay ku kordheysaa kuleylka (gration) | Hoos udhac ah oo hoos udhaca heerkulka kala duwan |
| Xakamee Viscosity | Xadidan Xadidan ee Viscosity | Xakamaynta weyn ee ku saleysan viscosity ku saleysan heerka fasalka iyo kan ku beddelashada |
4. Codsiyada
Labadaba MC iyo HPMC labaduba waxay si balaadhan u adeegsadaan dawooyinka, cuntada, iyo warshadaha waxyaabaha la isku qurxiyo, laakiin guryaha gaarka ah ee mid kasta oo midkiiba ka dhigo mid ku habboon codsiyada qaarkood.
Methylrcellulose (MC):
Dawooyinka dawarrada: MC-da waxaa badanaa loo isticmaalaa sidii laba-geesood, kala-sooc, iyo wakiilka dahaadhka ah ee qaataha kiniiniga ah sababtuna tahay guryahooda. Waxaa sidoo kale loo isticmaalaa in lagu xakameeyo xakamaynta la xakameynayo.
Warshadaha cuntada: MC waxaa loo isticmaalaa sidii cunno dhumuc weyn, emulsifier, iyo xasilin. Hantiheeda Gel-sameynta waa mid qiimo leh sameynta alaabada sida jalaatada, dharka saladh, iyo waxyaabaha rootida duqeeysa.
Waxyaabaha la isku qurxiyo: MC waxaa loo isticmaalaa is-qurxinta qaro weyn, emulsitation, iyo xasilinta guryaha ee badeecadaha sida dheecaanka, shaambo, iyo kareemada.
Hydroxypropyl methylrcellesulose (HPMC):
Dawooyinka dawarrada: HPMC waxaa si weyn loogu adeegsadaa sida wakiilka loo sii daayo iyo ka-bixitaanku inuu yahay mid ka mid ah qaababka kiniiniga. Waxaa sidoo kale loo isticmaalaa xalka ophthalmic sida saliidaha iyo nidaamyada gaarsiinta daroogada ee ku saleysan Gel.
Warshadaha cuntada: HPMC waxaa loo isticmaalaa dubitaanka-bilaashka ah ee gluten-ka, maadaama ay ku yar tahay qaab dhismeedka iyo qufulka gluten cajiinka. Waxaa sidoo kale loo isticmaalaa sidii xasillooni iyo emulsifier xagga cuntooyinka kala duwan ee laga baaraandego.
Dhismo: HPMC waxaa loo istcimaalaa sidii wax lagu daro oo sibidhka ah, malaasta, iyo tile adhessies. Waxay wanaajisaa la-shaqeynta, haynta biyaha, iyo is-hoosaadka.
| Isticmaal | Methylrcellulose (MC) | Hydroxypropyl methylrcellesulose (HPMC) |
| Dawooyinka dawarrada | Xargaha, kala-sooca, wakiilka dahaarka | Xambalyada, xakamaynta, saliidaha ophthalmic |
| Warshadaha cuntada | Dhumuc weyn, emulsifier, xasilin | Dubitaanka Gluten-bilaashka ah, xasilinta, emulsifier |
| Waxyaabaha la isku qurxiyo | Dhumuc weyn, emulsifier, xasilin | Dhumuc weyn, xasilin, emulsifier |
| Dhismo | Si dhif ah loo adeegsaday | Ku darista sibidhka, malaast, adhesies |
5. Guryaha kale
Hygroscopicity: HIPMC guud ahaan waa inbadan oo hygroscopic (soo jiidasho leh) marka loo eego MC, oo ka dhigaysa mid waxtar u leh codsiyada meesha loo baahan yahay haynta qoyaanka.
Xasiloonida kuleylka: MC waxay u egtahay inay soo bandhigtay xasillooni yar oo kuleylka ah sababtuna tahay hantideeda. HPMC, inta uu xasilloon yahay heerkulka ballaaran, waxaa laga yaabaa inaysan bixin saameynta ay kululeeyaan kuleylka ee isla MC.
6. Soo Koobid Kala duwanaanshaha
| Muujinta | Methylrcellulose (MC) | Hydroxypropyl methylrcellesulose (HPMC) |
| Qaab-dhismeedka kiimikada | Kooxaha methyl ku lifaaqan cellulose | Methyl iyo koollada hydroxypropyl ee ku lifaaqan cellulose |
| Xaraash | Biyo kulul, qaabeeda | Ku milma biyaha qabow iyo biyaha kulul ee labadaba |
| Hantida Getation | Waxay ka qaataan jel qaboojinta | Ganacsi la'aan, wali wuu sii jeedaa |
| Vecyosisto | Heerkulka-ku-tiirsanaanta, kuleylka kuleylka | Viscosity deganaanshuhu dhan |
| Codsiyada | Dawooyinka, cuntada, waxyaabaha la isku qurxiyo | Dawooyinka, cuntada (gluten-bilaash ah), qurxinta, dhismaha |
| Hygroscopicity | Ka hooseeya HPMC | Ka sareeya, waxay soo jiidataa qoyaan badan |
Halka labadabaHPMCiyoMCMa yihiin astaamaha unugyada unugyada oo leh isku-darka codsiyada, qaabdhismeedka kiimikada ee kala duwan iyo guryaha ay ka dhigaan iyaga ku habboon adeegsiga kala duwan. MC-da ayaa si gaar ah ugu qiimo badan codsiyada ka tanaasulida hantida uu ka faa'iideysto, halka silsiladda sare ee HPMC iyo xasilloonida kuleylka ay ka dhigeyso mid ka sii badan warshadaha, oo ay kujirto kahortaga cuntada iyo dawooyinka. Fahmitaanka khilaafaadkani waxay ka caawineysaa xulashada maaddooyinka ku habboon ee codsiyada gaarka ah.
Waqtiga Post: Jan-27-2025