Hydroxyethyl Methyl Cellulose

Ether-ka Cellulose waa maaddo kiimiko ah oo wanaagsan oo polymer ah oo si weyn loo isticmaalo oo laga sameeyay cellulose polymer-ka dabiiciga ah iyada oo loo marayo daawaynta kiimikada. Ka dib markii la soo saaray nitrate cellulose iyo cellulose acetate qarnigii 19-aad, farmashiyeyaashu waxay soo saareen taxane cellulose ah oo ka mid ah ethers cellulose badan, iyo beero cusub oo codsi ah ayaa la helay si joogto ah, oo ku lug leh qaybo badan oo warshado ah. Alaabooyinka cellulose ether sida sodium carboxymethyl cellulose (CMC), ethyl cellulose (EC), hydroxyethyl cellulose (HEC), hydroxypropyl cellulose (HPC), methyl hydroxypropyl cellulose (MHEC) iyo methyl hydroxypropyl cellulose (MHPC) iyo ethers kale cellulose ayaa loo yaqaan. "Monosodium glutamate warshadaha" waxaana si weyn loogu isticmaalay qodista saliidda, dhismaha, dahaarka, cuntada, daawada iyo kiimikooyinka maalinlaha ah.

Hydroxyethylmethylcellulose(MHEC) waa budo cad oo aan ur lahayn, dhadhamin, aan sun ahayn oo lagu milmi karo biyo qabow si loo sameeyo xal muuqda oo muuqda. Waxay leedahay sifooyin dhumuc, xidhidh, kala firdhiyo, emulsifying, filim samaynta, laalista, adsorbing, gelling, dusha firfircoon, ilaalinta qoyaan iyo ilaalinta kolloid. Sababtoo ah shaqada firfircoon ee dusha sare ee xalka aqueous, waxaa loo isticmaali karaa sida wakiilka ilaalinta kolloidal, emulsifier iyo kala firdhiso. Hydroxyethyl methylcellulose aqueous aqueous ayaa leh biyo nadiif ah oo wanaagsan waana wakiil biyo celin hufan. Sababtoo ah hydroxyethyl methylcellulose waxay ka kooban tahay kooxaha hydroxyethyl, waxay leedahay awood wanaagsan oo ka hortagga caarada, xasiloonida viscosity iyo caabbinta caarada inta lagu jiro kaydinta muddada dheer.

Hydroxyethyl methylcellulose (HEMC) waxaa lagu diyaariyaa soo bandhigidda beddelka ethylene oxide (MS 0.3 ~ 0.4) ee methylcellulose (MC), iyo caabbinta milixdu waxay ka fiican tahay kuwa polymers-ka aan la bedelin. Heerkulka gelation ee methylcellulose sidoo kale wuu ka sarreeyaa kan MC.

Qaab dhismeedka:

Tilmaam:

Astaamaha ugu muhiimsan ee hydroxyethyl methylcellulose (HEMC) waa:

1. Solubility: Ku milmay biyaha iyo qaar ka mid ah dareerayaasha organic. HEMC waxa lagu milmi karaa biyo qabow. Xoojinteeda ugu sareysa waxa kaliya oo lagu go'aamiyaa viscosity. Solubility wuxuu ku kala duwan yahay viscosity. Maqnaanshaha hoose, waa ka sii weynaanta milanka.
2. Iska caabbinta milixda: Alaabooyinka HEMC waa ethers-cellulose aan-ionic ahayn oo ma aha polyelectrolytes, markaa waxay ku xasilloon yihiin xalalka aqueous marka cusbada birta ah ama electrolytes organic ay jiraan, laakiin ku darida xad-dhaafka ah ee electrolytes waxay sababi kartaa qulqulka iyo roobka.
3. Dhaqdhaqaaqa dusha sare: Sababtoo ah shaqada firfircoon ee dusha sare ee xalka aqueous, waxaa loo isticmaali karaa sida wakiilka ilaalinta kolloidal, emulsifier iyo kala firdhiso.
4. Gel kuleyl ah: Marka xalka biyaha ee alaabada HEMC lagu kululeeyo heerkul gaar ah, wuxuu noqdaa mid mugdi ah, jel ah, oo soo da'aya, laakiin marka si joogto ah loo qaboojiyo, waxay ku noqotaa xalalka asalka ah, iyo heerkulka uu ku jiro jelkan iyo roobabka. Dhacdadu waxay inta badan ku xiran tahay iyaga saliidaha, qalabka joojinta, kolloysyada ilaalinta, emulsifiers iwm.
5. Dheef-shiid kiimikaad oo hooseeya iyo urta iyo udgoonka oo hooseeya: HEMC si weyn ayaa loogu isticmaalaa cuntada iyo daawada sababtoo ah ma metabolismi doono oo waxay leedahay ur iyo udgoon yar.
6. Caabbinta caariyaysi: HEMC waxay leedahay caabbinta caariyaysiga ilaa xad wanaagsan iyo xasilloonida viscosity wanaagsan inta lagu jiro kaydinta muddada-dheer.
7. Xasiloonida PH: Viscosity ee xalka aqueous ee alaabta HEMC si dhib leh uma saamayso aashitada ama alkali, iyo qiimaha pH waa mid deggan inta u dhaxaysa 3.0 ilaa 11.0.

Codsiga:

Hydroxyethyl methylcellulose waxaa loo isticmaali karaa sida wakiilka kolloidal ilaalinta, emulsifier iyo kala firdhiso ay sabab u tahay shaqada dusha-firfircoon ee xal aqueous. Tusaalooyinka codsiyadeedu waa sida soo socota:

1. Saamaynta hydroxyethyl methylcellulose ee waxqabadka sibidhka. Hydroxyethyl methylcellulose waa ur aan ur lahayn, dhadhamin, budo cad oo aan sun ahayn oo lagu milmi karo biyo qabow si loo sameeyo xal hufan. Waxay leedahay sifooyin dhumuc, xidhidh, kala firdhiyo, emulsifying, filim samaynta, laalista, adsorbing, gelling, dusha firfircoon, ilaalinta qoyaan iyo ilaalinta kolloid. Maadaama xalka aqueous uu leeyahay dusha sare si firfircoon u shaqeynaya, waxaa loo isticmaali karaa sida wakiilka ilaalinta kolloidal, emulsifier iyo kala-firdhiye. Hydroxyethyl methylcellulose aqueous aqueous ayaa leh biyo nadiif ah oo wanaagsan waana wakiil biyo celin hufan.
2. Rinjiga gargaarka leh dabacsanaan sare ayaa la diyaariyaa, kaas oo ka samaysan alaabta ceeriin ee soo socota ee qaybaha miisaanka: 150-200 g oo ah biyo deionized; 60-70 g oo ah emulsion acrylic saafi ah; 550-650 g oo ah calcium culus; 70-90 g oo ah budada talcum; 30-40 g oo ah xal aqueous cellulose; 10-20 g lignocellulose xal aqueous; 4-6g gargaar samaynta filimada; 1.5-2.5g oo ah jeermiska dila iyo bakteeriyada; 1.8-2.2g kala firidhsan; 3.5-4.5g; Ethylene glycol 9-11g; Xalka aqueous hydroxyethyl methylcellulose waxaa lagu sameeyaa iyadoo lagu milmay 2-4% hydroxyethyl methylcellulose biyaha; Xalka aqueous lignocellulose waxa laga sameeyaa 1-3 % Lignocellulose waxa lagu milmaan biyo.

Diyaarinta:

Habka diyaarinta ee hydroxyethyl methylcellulose, habka waa in la isticmaalo suuf la safeeyey sida alaabta ceeriin iyo ethylene oxide sida wakiilka etherification si loogu diyaariyo hydroxyethyl methylcellulose. Qaybaha miisaanka ee alaabta ceeriin ee diyaarinta hydroxyethyl methyl cellulose waa sida soo socota: 700-800 qaybo ka mid ah toluene iyo isopropanol isku dar ah sida dareere ah, 30-40 qaybood oo biyo ah, 70-80 qaybaha sodium hydroxide, 80-85 qaybo ka mid ah suuf la safeeyey, giraanta 20-28 qaybaha oxyethane, 80-90 qaybaha methyl chloride, 16-19 qaybaha glacial acetic acid; Tallaabooyinka gaarka ah waa:

Talaabada koowaad, ee kiliyaha falcelinta, ku dar toluene iyo isopropanol isku dar ah, biyo, iyo sodium hydroxide, kuleyl ilaa 60-80 ° C, diirimaad 20-40 daqiiqo;

Talaabada labaad, alkalization: qabooji walxaha kor ku xusan 30-50 ° C, ku dar suuf la safeeyey, buufin toluene iyo isopropanol dareeraha isku dhafka ah, ku shub 0.006Mpa, buuxi nitrogen ee 3 beddelka, oo ful ka dib beddelka Alkalinization, Xaaladaha alkalization waa: wakhtiga alkalization waa 2 saacadood, iyo heerkulka alkalization waa 30 ° C ilaa 50 ° C;

Talaabada saddexaad, etherification: ka dib marka alkalization la dhammeeyo, reactor ayaa loo daadgureeyay 0.05-0.07MPa, iyo ethylene oxide iyo chloride methyl waxaa lagu daraa 30-50 daqiiqo; marxaladda koowaad ee etherification: 40-60 ° C, 1.0-2.0 Saacadaha, cadaadiska waxaa lagu xakameynayaa inta u dhaxaysa 0.15 iyo 0.3Mpa; Marxaladda labaad ee etherification: 60～90℃, 2.0～2.5 saacadood, cadaadiska waxaa lagu xakameynayaa inta u dhaxaysa 0.4 iyo 0.8Mpa;

Talaabada afraad, dhex dhexaadnimada: Horey ugu darso aashitada glacial acetic acid ka hor kistuurka roobka, ku cadaadi walxaha etherified si aad u dhexdhexaadiso, kor u qaad heerkulka ilaa 75-80 ° C roobka, heerkulku wuxuu kor u kacaa 102 ° C, iyo pH qiimuhu waa 6 Saacada 8, xaalufinta waa la dhammeeyaa; Taangiga bakhtiyaa-nasiibka waxaa ka buuxsamay biyaha tuubada oo lagu daweeyay qalab kale oo osmosis ah oo ah 90 ° C ilaa 100 ° C;

Talaabada shanaad, dhaqidda centrifugal: walxaha ku jira tillaabada afraad waxaa lagu dhejiyaa iyada oo loo marayo screw centrifuge, iyo walxaha kala sooca ayaa loo wareejiyaa haanta dhaqidda oo ay ka buuxaan biyo kulul horay loogu dhaqay alaabta;

Talaabada lixaad, qalajinta centrifugal: walxaha la dhaqay waxaa loo gudbiyaa qalajiyaha iyada oo loo marayo centrifuge toosan, walxahana waa la qalajiyey 150-170 ° C, alaabta la qalajiyey waa la jajabiyey oo la duubay.

Marka la barbar dhigo tignoolajiyada wax soo saarka ether cellulose ee jira, hal-abuurka hadda wuxuu isticmaalaa ethylene oxide sida wakiilka etherification si uu u diyaariyo hydroxyethyl methyl cellulose, kaas oo leh awood wanaagsan oo ka hortagga caaryada sababtoo ah ka kooban kooxaha hydroxyethyl. Waxay leedahay xasiloonida viscosity wanaagsan iyo caabbinta caariyaysiga inta lagu jiro kaydinta muddada dheer. Waxaa loo isticmaali karaa halkii ethers kale ee cellulose.