HPMC waxay isticmaashaa dahaadhka kiniinka

dahaarka kiniinka waxaa guud ahaan loo isticmaalaa diyaarinta qaab adag, sida uu qabodahaarka kiniinka alaabta waxaa loo qaybin karaa budodahaarka kiniinka, pelletdahaarka kiniinka, qaybdahaarka kiniinka, tabletdahaarka kiniinka, kaabsaldahaarka kiniinka; Sida laga soo xigtaydahaarka kiniinka alaabtu waxay u qaybsantaa sonkordahaarka kiniinka, filim badhkeeddahaarka kiniinka, filimdahaarka kiniinka (oo ku salaysan noocyo kala duwan oo qalab polymer ah, oo ay ku jiraan entericdahaarka kiniinka), qalab gaar ahdahaarka kiniinka (sida stearic acid, paraffin, polysaccharide); Sida laga soo xigtaydahaarka kiniinka technology, waxa loo qaybin karaa buufindahaarka kiniinka, ku dhufodahaarka kiniinka, cadaadis qallalandahaarka kiniinka, electrostaticdahaarka kiniinka iyo laminatingdahaarka kiniinka. Waxaa ka mid ah, buufindahaarka kiniinka waa kan ugu isticmaalka badan. Mabda'adeedu waa in la buufiyodahaarka kiniinka dareere galay dhibco ceeryaamo ah oo daboolaya dusha sare ee alaabta (budada, qaybo, kiniinno). Oo si degdeg ah u engegan si ay u sameeyaan ahdahaarka kiniinka lakabka: sida uu qabodahaarka kiniinka Ujeedadu waxay u qaybsantaa biyo milmaydahaarka kiniinka, calool milmadahaarka kiniinka, aan la milmindahaarka kiniinka, si tartiib ah u sii dayndahaarka kiniinka, galleydahaarka kiniinka.

Doorkadahaarka kiniinka waxaa ka mid ah: (1) qoyaan-celinta, iftiinka, go'doominta hawada si loo kordhiyo xasilloonida daroogada; (2) Dabool ur xun, yaree kicinta; (3) Hagaajinta muuqaalka, fududahay in la aqoonsado; (4) Xakamee goobta lagu sii daayo dawada, sida casiirka gastric si fudud in loo burburiyo si ay mindhicirka ugu soo daayaandahaarka kiniinka Maaddadu waa inay lahaataa shuruudahan soo socda: aan sun ahayn, malaha kiimikaad qallafsan, ku xasilloon kulaylka, iftiinka, biyaha, hawada, oo aan ka falcelinaynindahaarka kiniinka daroogooyinka; (2) waxaa lagu kala diri karaa si siman u kala firdhiyey dhex dhexaadinta kala firidhsan ee ku habboondahaarka kiniinka: (3) waxay samayn kartaa lakab joogto ah, adag, siman, iska caabin dildilaac ah oo leh go'doomin wanaagsan oo biyo ah, go'doomin qoyaan, hadh, qulqulka hawada;④Solubleedkeedu waa inuu buuxiyaa shuruudaha - go'an, mararka qaarkood uma baahna inay saamayso PH, marmarka qaarkood waxay ku milmi kartaa oo keliya qayb PH gaar ah. Nooc ka mid ah walxaha leh sifooyin ka sarreeya isla waqti isku mid ah lama arko wax badan, sababtu waxay u egtahay in ay isticmaasho isku dhafandahaarka kiniinka wax badan, si ay wax uga bartaan midba midka kale.

Kiniinkadahaarka kiniinka waa tan ugu isticmaalka badan, inta badan waxay isticmaashaa dheridahaarka kiniinka iyo tuubo la aasaydahaarka kiniinka (waxtarka saredahaarka kiniinka mashiinkadahaarka kiniinka), kan dambe ayaa u fiican filimkadahaarka kiniinka. Sariir dareere lehdahaarka kiniinka wuxuu aad ugu habboon yahay alaabta leh cabbirka walxaha yaryar sida pellets iyo budada. Marka la barbardhigo sonkortadahaarka kiniinka, filimdahaarka kiniinka wuxuu leeyahay faa'iidooyin badan 1) Yaraynta wakhtiga oo yaree kharashka alaabta; (2) Ma jiro koror weyn oo miisaan ah: (3) Looma baahna lakabka hoose: (4) iska caabin xoog leh, burburin iyo dildilaac ah: (5) waa la daabici karaa, sidoo kale saameyn kuma yeelanayso xarafka jajabka;6) Wuxuu si wax ku ool ah uga ilaalin karaa badeecada saamaynta iftiinka, hawada iyo biyaha; (7) Wax saamayn xun ku yeelan maayo wakhtiga kala daadsanaanta 8) bilicda alaabta 9) waxay siisaa fursad lagu isticmaalo biyo aan ahayndahaarka kiniinka; Hababka iyo agabka waa la jaangooyn karaa. Hadda horumarinta alaabta cusubdahaarka kiniinka diyaarinta guud ahaan qaadataa filimkadahaarka kiniinka, filimdahaarka kiniinka Halabuurka aasaasiga ah ee rijeetada waxaa ka mid ah wakiilka sameynta filimada (dahaarka kiniinka wax), dareere, plasticizer, colorant, sidoo kale ku dari kartaa wakiilka dalool, buuxinta aan la karin, iwm .. Halabuurka filimkadahaarka kiniinka rijeetada waa furaha guushadahaarka kiniinka. Waqtigan xaadirka ah, filim biyo-milmi lehdahaarka kiniinka Qalabka sida caadiga ah loo isticmaalo waxaa ka mid ah hydroxypropyl methyl cellulose (HPMC) iyo hydroxypropyl cellulose (HPC). Polyethylene glycol (PEG), polyetylen pyrrolidone (PVP), agabka gudaha-milmi kara oo ay ku jiraan xabagta acrylic-gale, hydroxypropyl methyl cellulose phthalate (HPMCP). Cellulose acetate phthalate ester (CAP). Shellac, walxaha aan milmi karin waxaa ka mid ah ethyl cellulose (EC), zein.

Sanado badan, filimdahaarka kiniinka wuxuu sameeyay horumar la taaban karo. Halbeegga dhaqankadahaarka kiniinka hab isticmaalkaHPMC(hydroxypropyl methylcellulose) oo ah polymer-ka ugu weyn, kaas oo weli si ballaaran loo isticmaalo maanta. HPMC-ku salaysandahaarka kiniinka Nidaamyadu waxay bixiyaan waxqabad ku filan, laakiin weli waxaa jira meel lagu hagaajin karo. HPMCdahaarka kiniinka filimku waxa laga yaabaa in aanu si fiican ugu dheggan kiniinka, badiyaa dheerdahaarka kiniinka waqti, taasoo keentay in wax soo saarka gaabis ah. Hordhaca danbe eePVA ku salaysan dahaarka kiniinka Nidaamyadu waxay sii wanaajiyeen shaqeynta, taasoo keentay fiicnaandahaarka kiniinka waxqabadka iyo waxtarka wax soo saarka degdega ah, taas oo macnaheedu yahay in cilladuhu ay aad ugu yar yihiin inay ku dhacaan kiniinka.

Marka uu viscosity ee HPMC kordho, xoogga filimka ay samaysay HPMC waxay kordhisaa si isku mid ah, oo ugu dambeyntii gaaro awoodda filimka ugu badan mar dambe ma kordhiso kororka viscosity ee HPMC.

Gudahadahaarka kiniinka, si loo gaaro sida ugu hufandahaarka kiniinka, inta badan wanaajisodahaarka kiniinka dareere adag content, taas oo u horseedi doona in aydahaarka kiniinka viscosity dareere waa mid aad u sarreeya, dooro viscosity hooseeyo HPMC si wax ku ool ah u xalin kara dhibaatadan, laakiin waxay keenaysaa in xoogga filimka la saameeyo. Si loo dheellitiro dhibaatooyinkan mataanaha ah, isku dhafka polymers wuxuu noqday qalab caadi ah.

SidaHPMCcontent E15 si tartiib tartiib ah u kordho, viscosity ee isku dar ah eeHPMCE5 iyoHPMCE15 ayaa sidoo kale si tartiib tartiib ah u kordheysa.

Sonkorta ku jirtadahaarka kiniinka, sidoo kale waxaan ka soo baxnay fanka una gudubnay cilmiga. Alaabooyinka sonkorta lagu dahaadhay ayaa si quruxsan u raaxaysanaya sababtoo ah waxay leeyihiin dhammays siman, dhalaal, macaan oo qariya dhadhanka qadhaadhka ah. Laakiin caqabadaha ugu waaweyn ee sonkortadahaarka kiniinka ku jiifso wax soo saarka iyo taranka. Sonkordahaarka kiniinka waa hawl aad u hawl badan oo wakhti badan qaadanaysa waxaana laga yaabaa inay ku kala duwanaato dufcaddii iyadoo ku xidhan qofka samaynayadahaarka kiniinka.