Marka hore, soo gaabinta Ingiriisiga ee agabka caawinta
MC: Methyl cellulose
EC: ethyl cellulose
HPC: hydroxypropyl cellulose
HPMC: hydroxypropyl methylcellulose
CAP: Cellulose acetate phthalates
HPMCP: phthalates hydroxypropyl cellulose
HPMCAS: hydroxypropyl methyl cellulose acetate succinate
Cmc-na: Sodium carboxymethyl cellulose
MCC: Microcrystalline cellulose
PVP: Povidone
PEG: polyetylen glycol
PVA: khamriga polyvinyl
Cms-na: Sodium karboxymethyl istaarijka
PVPP: Povidone-ku-xiran
CCNa: sodium carboxymethyl cellulose oo isku xidhan
Labo, isticmaalka qaar ka mid ah agabka caawinta
1. Lactose: tablet: filler, gaar ahaan budada kiniiniga tooska ah;Duritaan: ilaaliye lyophilized
2. Microcrystalline cellulose: kaniini: budada si toos ah loo riixo kiniiniga buuxinta;"Xabag qallalan";Kiniinada ka kooban 20% microcrystalline cellulose waxay u dhaqmaan sidii kala-baxayaal
3. Methyl cellulose: kiniinka: koolo;Wakiilka cayrinta: gargaarka cayrinta;Diyaarinta si tartiib ah (la xakameeyey) diyaarinta: Qalfoofka jel hydrophilic (daciif ah)
4 sodium carboxymethyl cellulose: kiniinnada: xabagta;Wakiilka cayrinta: gargaarka cayrinta;Si tartiib ah (xakameyn) diyaarinta sii deynta: Qalfoofka jel hydrophilic
5. Ethyl cellulose: kiniin: koollo (aan biyo ku milmin);Diyaarinta si tartiib tartiib ah (la xakameeyey): walxaha qalfoofka ama walxaha la xakameeyey xuubabka;Kala firdhisan adag: walax side aan milmi karin
6 hydroxypropyl cellulose: kiniiniga: xabagta, walxaha dahaarka filimka;Wakiilka cayrinta: gargaarka cayrinta;Diyaarinta si tartiib ah (la kantaroolo) siideynta: walxo qalfoofka jel hydrophilic, xuubka microporous ee dahaarka leh ee xaashida daldaloolada
7. Hydroxypropyl methyl cellulose (hydroxypropyl methyl cellulose): kiniiniga: xabagta, walxaha dahaarka filimka;Wakiilka cayrinta: gargaarka cayrinta;Diyaarinta sii deynta qunyar socodka ah oo la kontoroolo: Qalfoofka jel hydrophilic, xuubka microporous ee dahaarka leh ee xaashida daldaloolada
8. Cellulose acetate phthalates: walxaha galmoodka ah
9. Hydroxypropyl cellulose phthalates: walxaha galmoodka ah
10. Hydroxypropyl cellulose acetate succinate: walxaha galmo
11. Polyvinyl phthalate (PVAP): walxaha galmoodka ah
12. Styren Maleic acid copolymer (StyMA): walxaha milmay ee mindhicirka
13. Resin Acrylic (nooca galmoodka I, II, III), Eudragit L, Eudragit S (mararka qaar Eudragit L100 ama Eudragit S 100): walxaha galmoodka
14.Eudragit RL, Eudragit RS: Walxaha sideyaasha aan milmi karin
15.Eudragit E (oo u dhiganta acrylic IV): maadada polymer-ka ee caloosha
16. Cellulose acetate: wax biyo ah oo aan milmi karin, waxaa loo isticmaali karaa daahan ama diyaarinta kiniiniyada bamka osmotic
17. Polyvinylpyrrolidone (povidone PVP): kiniinnada: xabagta;Kiniiniga: walxaha dahaarka filimka caloosha ku milma;Pellets: nifedipine pellets (kala firidhsan adag);Wakiilka cayrinta: gargaarka cayrinta;
Kala firdhisan adag: walxaha sidaha biyaha ku milma;Si tartiib ah (xakameyn) diyaarinta sii deynta: walxaha qalfoofka kolloid hydrophilic;Diyaarinta sii deynta qunyar (xakamaysan): wakiilka daldabada keena ee kiniinnada xuubka yar yar ee kiniinnada dahaarka leh
18. Khamriga Polyvinyl: wakiilka filimka: walxaha samaynta filimada, gargaarka joojinta
19. Sodium carboxymethyl istaarijka: tablet: wakiilka kala daadsan
20. Cross-linked povidone: Tablet: disintegrant
21. Crosslinked sodium carboxymethyl cellulose: kiniinka: wakiilka kala daadsan
22. Hydroxypropyl cellulose oo hooseeya-la beddelay: Kiniiniga: kala daadsan
23. Polylactic acid: walxaha polymer biodegradable, oo loo isticmaalo diyaarinta microspheres, nanoparticles, iwm.
24. Glycerol (sorbitol propylene glycol wuxuu si aad ah ugu dhow yahay glycerol)
Diyaargarowga dareeraha: dareeraha, dareeraha duritaanka, gargaarka joojinta, qoyaanka
Balaastiijiyaha ku jira kaabsulka iyo walxaha dahaarka
Saliidda, hababka gudbinta transdermal: dhiirrigeliyeyaasha dhexgalka
Kordhi qoynta dawooyinka hydrophobic, xakamaynta cadaadiska osmotic ee emulsion dufanka xididada.
Gelatin Glycerin (loogu talagalay boomaatada, subsiyada, kala firidhsanaanta adag)
25. Glycerin gelatin
Kiniinnada la tuuro: matrix biyo-milmi kara
Suppository: matrix biyo-milmi kara
Saliidda: Matrixka biyaha milmaya
26. Sodium dodecyl sulfate (anionic surfactant)
Emulsions, boomaatada: emulsifiers
Wakiilka qoynta ee diyaargarowga adag / saliidaha kiniinnada
solubilizer
27. Polyethylene glycol (PEG)
Kiniinnada: Saliidaha biyaha ku milma (PEG 4000, 6000)
Kiniiniga: Plasticizer-ka ku jira warqadda daawada daahan
Kaabsulka: Dhexdhexaad dareere ah oo jilicsan oo aan saliid lahayn (PEG 400)
Kiniinnada tuurista: matrixka biyaha-milmi kara (PEG 4000, 6000,9300)
Suppository: matrix suppository
Aerosol: dareere qarsoon (PEG 400, 600)
Duritaan: Solvent (PEG 400, 600)
Diyaarinta dareeraha: Solvent (PEG 400, 600)
Kala firdhisan adag: qaade
Diyaarinta sii deynta qunyar (xakamaysan): wakiilka daldabada keena ee kiniinnada xuubka yar yar ee kiniinnada dahaarka leh
Diyaarinta nuugista ee percutaneous: kobciyaha nuugista transdermal
28. Poloxam (” zwitterionic “surfactant) Saaxiib taxaddar leh ayaa halkan ku arkay farqi, hadda waa la saxay” Poloxam “surfactant-ka-aan-ionic, ma aha surfactant zwitterionic!
Qaade fidsan oo adag, matrix suppository, emulsifier for injection ama faleebo
Soo koobida jeermiska jeermiska iyo bakteeriyada
Hydroxyl benzene ester (dahab neper), benzoic acid, sodium benzoate, sorbic acid, benzalkonium bromide (cusub nadiif ah), benzalkonium chloride (jie er die), chlorhexidine acetate, benzyl alkohol (xanuun maxalli ah) isku mar, cross-linked. oo leh alkolada butyl-ka sare ah (xanuun maxalli ah) isku mar, nitrobenzene, mercury, thimerosal, jeermiska jeermiska, ortho-phenyl phenol, phenoxyethanol, saliid eucalyptus, saliid qorfe, saliid basbaas, iwm.
Afar, habka jeermiska
1/ Duritaan gulukoos, emulsion dufan oo loogu talagalay duritaanka xididada, dextran, faleebo sodium chloride, balaastig caag ah iyo nadiifin cadaadis kale oo kulul;
2/ Faytamiin C duritaanka, duritaanka procaine hydrochloride, cortisone acetate duro, chloramphenicol indhaha dhibciyada waxaa lagu jeermis dilay uumi wareegaya;
3/ Saliid duritaan, matrix dufan, ampoule iyadoo la adeegsanayo habka jeermiska kulaylka qalalan;
4/ Hawo qolka Asepsis, oogada miiska shaqada: Habka jeermiska ultraviolet ama habka qiiqa gaaska;
5/ Gacan, qalabka aseptic: habka jeermiska kiimikada
6/ duritaanka Insulin-ka iyo waxyaabaha kale ee bayooloji: habka nadiifinta
V. Isla'egyada la xidhiidha
1. Noyes-whitney isla'egta: waxay qeexaysaa heerka kala dirida daawooyinka adag.
2. Qoyaanka halista ah ee isku dhafka ah
hygroscopicity ee budada P68)
3. Qiimaha beddelkasuppository P87)
4. Qaaciddada Poiseuile: sharax waxyaabaha saamaynta ku leh sifaynta (murdida P124)
5. Xisaabinta qaacidada isotonic nidaaminta iyadoo la isticmaalayo habka hoos u dhigista barafkairbad P156)
6. Xisaabinta qiimaha HLB ee surfactant isku dhafandareere P178)
Farsamada diyaarinta ee ku habboon
1. Microcapsule: Habka uumi (hal, adag), habka dareere-non-milmi, habka heerkulka beddelka, habka qalajinta dareere, habka qalajinta, buufin habka uumiga, habka hakinta hawada, habka uumi interface, habka crosslinking shucaaca
2. Isku-darka isku-darka: Habka xalinta aqueous-ka oo buuxa, habka shiida, habka qalajinta qaboojiya, habka qalajinta buufin
3. Kala firdhisanaanta adag: Habka dhalaalka, habka dareeraha, dareeraha - habka dhalaalka, dareeraha - habka qalajinta buufin, habka wax lagu shiido
4. Liposomes: Habka duritaanka, habka fidinta filimka khafiifka ah, habka fidinta ultrasonic, habka uumiga wajiga rogan, habka qalajinta qaboojinta
5. Microspheres: emulsification - habka daaweynta, habka qalajinta buufinta, habka qalajinta dareeraha
6. Nanoparticles: polymerization micellar, polymerization emulsion, polymerization interface, habka qalajinta dareeraha
7. Pellet: habka granulation karkaraya, habka granulation buufin, habka dheriga daahan, habka sphericity extrusion, habka centrifugal projectile, habka qalajinta dareere
8 suppository: habka dhalaalka kulul, habka qaboojinta cadaadiska, habka cajiinka
9. Saliidda: habka wax lagu shiido, habka dhalaalka, habka emulsification
10 wakiilka filimka: Habka samaynta filimka qulqulka qulqulka isku midka ah, habka samaynta filimka cadaadiska-dhalan, habka samaynta filimada isku dhafan
Toddoba, qalabka wakiillada
1. Microcapsule: jelatin - xanjo Carabi
2. Isku-darka isku-dhafka: cyclodextrin
3. Kala firdhisan adag: PEG, PVP
4. Liposomes: phospholipid-cholesterol
5. Microspheres: jelatin, albumin, PLA, iwm
6. Suppository: subagga kookaha
7. Saliid: Saliida Shidaalka, iwm
8 wakiilka filimka: PVA
Sideed, dhowr jeer
1. Qufulka jeermis-dilaaca ah waa in lagu tagaa wax aan ka badnayn 24 saacadood;
2. Kaydinta biyaha ee duritaanka waa in aanay ka badnayn 12 saacadood;
3. Madhalayska irbado guud waa in lagu dhammeeyaa 12 saacadood gudahood ka dib dheriga;
4. Faleebo iyo diyaarinta xalku waa in lagu dhammeeyaa 4 saacadood gudahooda ee jeermiska
9. Alaabooyinka hubinta tayada leh ee la xiriira diyaarinta daawooyinka
1. Kiniinnada: sifooyinka muuqaalka;Jeex kala duwanaanta miisaanka;Qallafsanaanta iyo qallafsanaanta;Shahaado kala go'a;Kala dirid ama sii dayn;Midnimada nuxurka
2. Wakiilka kala firdhiya: labbiska;QoyaankaFarqiga tirada rarida;Baaritaanka caafimaadka;Kormeerka granularity
3. Granule: muuqaal;Cabbirka walxaha;Miisaan qallalan oo luma;dhalaalin;Farqiga rarka
4. Kaabsoosha: muuqaal;QoyaankaFarqiga tirada rarida;Burburka iyo kala daadsanaanta.
5. Kiniinnada la tuuro: farqiga miisaanka;Kormeerka xaddidaadda wakhtiga kala dirida, iwm.
6. Suppository: muuqaalka;Kala duwanaanshaha miisaanka;Waqtiga xaddidan ee dhalaalka;Kala duwanaanshaha barta dhalaalka;Tijaabada kala dirida gudaha vivo iyo tijaabada nuugista in vivo
7. Plaster: cabbirka walxaha;Culayska;Xadka Microbial;Waxyaabaha ugu muhiimsan ee daroogada;Qalabka jirka;Wax kicinaya;Xasilooni;Siideynta, dhexgalka iyo nuugista daawooyinka boomaatada.
8. Xirmooyinka Transdermal: farqiga miisaanka;Farqiga aagga;Midnimada nuxurka;Shahaadada sii deynta, iwm.
10. Qeexitaanno kala duwan
1. Kaabsulka yar: waa kaabsal yar oo lagu sameeyay in lagu duuduubo dawo adag ama dareere ah (oo loo yaqaanno kaabsulka) maadada polymer-ka dabiiciga ah ama synthetic (loo yaqaan kaabsulka).1-5000 microns
2. Pellet: waxa loola jeedaa unugga wareegsan ee dhexroorkiisu ka yar yahay 2.5mm oo ka kooban dawooyin iyo qalabyo.
3. Microsphere: unug spherical nooc qalfoof ah oo la sameeyay iyadoo la kala diro ama kala firdhiso daroogooyinka qaab dhismeedka walxaha polymer, oo leh cabbirka qayb ka mid ah inta badan inta u dhaxaysa 1 iyo 250μm.
4. Nanoparticles: Qaybaha colloidal adag oo ka kooban walxaha polymeric, oo leh cabbirka qayb ka mid ah 10 ~ 1000nm.
5. Daawada kiniiniga: waxaa loola jeedaa dawooyinka adag ama dareeraha ah iyo walxaha ku habboon (guud ahaan loo yaqaan matrix) isku darka dhalaalidda kuleylka, ku rid uumiga qallafsan, uumiga foosha iyo diyaarinta pellet yar.
Waqtiga post: Seb-09-2022