Hydroxypropyl methylcellulose (HPMC) yakajairika polymer komboni ine dzakasiyana siyana dzekushandisa mumaindasitiri, kunyanya muminda yemishonga, chikafu, zvekuvaka uye zvekuzora. Kunyungudika kwayo kwemvura uye kukora zvivakwa kunoita kuti ive yakanaka thickener, stabilizer uye firimu rekare. Ichi chinyorwa chichakurukura zvakadzama nezvekuparara uye kuzvimba kweHPMC mumvura, pamwe nekukosha kwayo mumashandisirwo akasiyana-siyana.
1. Mamiriro uye zvivakwa zveHPMC
HPMC isiri-ionic cellulose ether inogadzirwa nekemikari kugadziriswa kwe cellulose. Chimiro chayo chemakemikari chine methyl uye hydroxypropyl substituents, iyo inotsiva mamwe emapoka ehydroxyl mu cellulose molecular chain, ichipa HPMC zvimiro zvakasiyana neaya echisikigo cellulose. Nekuda kwechimiro chayo chakasiyana, HPMC ine zvinotevera zvakakosha zvivakwa:
Kunyungudika kwemvura: HPMC inogona kunyungudika mumvura inotonhora uye inopisa uye ine yakasimba thickening zvivakwa.
Kugadzikana: HPMC ine kuchinjika kwakafara kune pH kukosha uye inogona kuramba yakagadzikana pasi pezvese acidic uye alkaline mamiriro.
Thermal gelation: HPMC ine hunhu hwekupisa gelation. Kana tembiricha yakwira, iyo HPMC aqueous solution inogadzira gel uye inonyungudika kana tembiricha yadonha.
2. Nzira yekuwedzera yeHPMC mumvura
Kana HPMC ikasangana nemvura, mapoka e hydrophilic mucheni yayo yemamorekuru (senge hydroxyl uye hydroxypropyl) anodyidzana nemamorekuru emvura kugadzira ma hydrogen bond. Izvi zvinoita kuti HPMC molecular cheni zvishoma nezvishoma kutora mvura uye kuwedzera. Iyo nzira yekuwedzera yeHPMC inogona kukamurwa mumatanho anotevera:
2.1 Danho rekutanga rekunyudza mvura
Kana HPMC zvimedu zvatanga kusangana nemvura, mamorekuru emvura anokurumidza kupinda mukati mezvimedu, zvichiita kuti pamusoro pezvikamu zviwedzere. Iyi nzira inonyanya kukonzerwa nekubatana kwakasimba pakati pemapoka e-hydrophilic mu HPMC mamorekuru uye mamorekuru emvura. Sezvo HPMC pachayo isiri-ionic, haizonyungudika nekukurumidza semaionic polima, asi inotora mvura uye kuwedzera kutanga.
2.2 Chinhanho chekuwedzera chemukati
Nekufamba kwenguva, mamorekuru emvura anopinda zvishoma nezvishoma mukati memukati mezvikamu, zvichiita kuti maketani e cellulose ari mukati mezvimedu atange kuwedzera. Huwandu hwekuwedzera hwezvikamu zveHPMC huchadzikira panguva ino nekuti kupinda kwemamorekuru emvura kunoda kukunda kurongeka kwakasimba kwemacheni emamorekuru mukati meHPMC.
2.3 Pedzisa danho rekuparara
Mushure menguva yakareba yakakwana, zvimedu zveHPMC zvinonyungudika zvachose mumvura kuita yunifomu viscous mhinduro. Panguva ino, cheni dzemamorekuru dzeHPMC dzinotenderedzwa mumvura, uye mhinduro yacho yakakora kuburikidza nekudyidzana kweintermolecular. Iyo viscosity yeHPMC mhinduro yakanyatsoenderana nehuremu hwayo hwemamorekuru, kugadzirisa kugadzirisa uye kupisa kwekupisa.
3. Zvinhu zvinokanganisa kuwedzera uye kuparara kweHPMC
3.1 Tembiricha
Iyo dissolution maitiro eHPMC ane hukama zvakanyanya nekupisa kwemvura. Kazhinji, HPMC inogona kunyungudutswa mumvura inotonhora uye inopisa mvura, asi kunyungudika maitiro anoita zvakasiyana pane tembiricha dzakasiyana. Mumvura inotonhora, HPMC inowanzotora mvura uye inoputika kutanga, uye zvishoma nezvishoma inonyungudika; ichiri mumvura inopisa, HPMC inozopinda mukati mekupisa kune imwe tembiricha, izvo zvinoreva kuti inoumba gel pane kugadzirisa pane tembiricha.
3.2 Kuisa pfungwa
Iyo yakakwira iyo yekumisikidzwa kweiyo HPMC mhinduro, iyo inononoka iyo particle yekuwedzera mwero, nekuti huwandu hwemamorekuru emvura mune yakanyanya kugadzirisa mhinduro inogona kushandiswa kusanganisa neHPMC molecular cheni ishoma. Mukuwedzera, iyo viscosity yemhinduro ichawedzera zvakanyanya nekuwedzera kwekutarisa.
3.3 Chikamu chekukura
Iyo particle size yeHPMC inokanganisawo kuwedzera kwayo uye kuparara rate. Zvimedu zvidiki zvinotora mvura uye kuzvimba nekukasira nekuda kwenzvimbo yazvo yakakura, ukuwo zvimedu zvihombe zvinotora mvura zvishoma nezvishoma uye zvichitora nguva yakareba kuti inyunguduke.
3.4 pH kukosha
Kunyangwe HPMC iine simba rinochinjika kune shanduko mupH, kuzvimba kwayo nekunyungudika maitiro anogona kukanganiswa pasi pemamiriro e acidic zvakanyanya kana alkaline. Pasi pekusarerekera kune isina kusimba acidic uye isina kusimba alkaline mamiriro, kuzvimba nekunyungudutswa kweHPMC kune kugadzikana.
4. Basa reHPMC mumashandisirwo akasiyana
4.1 Indasitiri yemishonga
Muindasitiri yemishonga, HPMC inoshandiswa zvakanyanya sebhainda uye disintegrant mumapiritsi emishonga. Sezvo HPMC ichizvimba mumvura uye ichigadzira gel, izvi zvinobatsira kunonoka kuburitswa kwemushonga, nekudaro kuwana inodzorwa yekuburitsa maitiro. Pamusoro pezvo, HPMC inogona zvakare kushandiswa sechinhu chikuru chemushonga firimu coating kusimudzira kugadzikana kwemushonga.
4.2 Zvishandiso zvekuvaka
HPMC inoitawo basa rakakosha mukuvaka, kunyanya semukobvu uye muchengeti wemvura wesamende dhaka uye gypsum. Iyo yekuzvimba pfuma yeHPMC mune izvi zvinhu inoita kuti ichengetedze hunyoro mukupisa kwakanyanya kana nharaunda dzakaoma, nekudaro kudzivirira kuumbwa kwekutsemuka uye kuvandudza kusimba kwekubatana kwezvinhu.
4.3 Indasitiri Yekudya
Muindasitiri yezvekudya, HPMC inoshandiswa seyakakora, emulsifier uye stabilizer. Semuenzaniso, mune zvakabikwa, HPMC inogona kuvandudza kugadzikana kwehupfu uye kugadzirisa magadzirirwo uye kuravira kwechigadzirwa. Pamusoro pezvo, kuzvimba zvimiro zveHPMC zvinogona zvakare kushandiswa kugadzira yakaderera-mafuta kana mafuta-isina chikafu kuwedzera satiety uye kugadzikana.
4.4 Zvizoro
Muzvizoro, HPMC inoshandiswa zvakanyanya muzvigadzirwa zvekuchengetedza ganda, shampoos uye maconditioner seyakakora uye inodzikamisa. Iyo gel inoumbwa nekuwedzera kweHPMC mumvura inobatsira kuvandudza kugadzirwa kwechigadzirwa uye inoumba firimu rinodzivirira paganda kuitira kuti ganda rive nemvura.
5. Pfupiso
Iyo yekuzvimba pfuma yeHPMC mumvura ndiyo hwaro hwekushandisa kwayo kwakakura. HPMC inowedzera nekutora mvura kuita mhinduro kana gel ine viscosity. Ichi chivakwa chinoita kuti chishandiswe zvakanyanya muminda yakawanda yakadai semishonga, kuvaka, chikafu uye zvizorwa.
Nguva yekutumira: Oct-09-2024