Hydroxypropyl methylcellulose (HPMC) inoshandiswa zvakasiyana-siyana inoshandiswa zvakanyanya mumaindasitiri emishonga, chikafu uye zvekuzora. Iyi cellulose inotorwa kubva kune yakasikwa cellulose uye yakagadziridzwa kuti iwane chaiyo zvivakwa, zvichiita kuti ive chinhu chakakosha mukugadzira kwakasiyana siyana.
1. Nhanganyaya yeHydroxypropyl Methylcellulose (HPMC)
1.1. Chimiro chemakemikari uye maitiro
Hydroxypropylmethylcellulose is semi-synthetic polymer inotorwa kubva ku cellulose, iyo huru yekuumbwa chikamu chechirimwa masero madziro. Iyo kemikari chimiro cheHPMC ine cellulose backbone units yakabatana nehydroxypropyl uye methyl mapoka. Huwandu hwekutsiviwa kwemapoka aya hunokanganisa kunyungudika, viscosity, uye zvimwe zvemuviri zvepolymer.
HPMC inowanzo chena kana isina-chena pakuonekwa, haina hwema uye isinganakidze. Inonyungudika mumvura uye inoumba zvakajeka, zvinogadzirisa zvinogadzirisa, zvichiita kuti zvive zvakakosha mune zvakasiyana-siyana zvekushandisa.
1.2. Manufacturing process
Kugadzirwa kwehydroxypropyl methylcellulose kunosanganisira etherification ye cellulose uchishandisa propylene oxide uye methyl chloride. Izvi zvinoshandura mapoka ehydroxyl mumaketani e cellulose, zvichitungamira mukuumbwa kwehydroxypropyl uye methyl ether mapoka. Kudzora dhigirii rekutsiva panguva yekugadzira inogonesa kugadzirisa kweHPMC zvivakwa.
2. Muviri uye makemikari zvinhu
2.1. Solubility uye viscosity
Chimwe chezvinhu zvakakosha zveHPMC kunyungudika kwayo mumvura. Muyero wekuparara unoenderana nehuwandu hwekutsiviwa uye huremu hwema molecular. Iyi hunhu hwekunyungudika inoita kuti ive yakakodzera kune akasiyana magadzirirwo anoda kudzorwa kuburitswa kana kuumbwa kwegel.
Iyo viscosity yeHPMC mhinduro inogadzirika zvakare, kubva pakadzika kusvika pakakwirira viscosity mamakisi. Ichi chivakwa chakakosha pakugadzirisa rheological zvimiro zvekuumbwa senge makirimu, gels uye ophthalmic mhinduro.
2.2. Kuita kwemafirimu
HPMC inozivikanwa nekugona kwayo kugadzira firimu, ichiita kuti ive chinhu chakakodzera chekuputira mahwendefa nemagranules. Iyo firimu inoguma iri pachena uye inochinjika, ichipa chidziviriro cheiyo inoshanda yemishonga ingredient (API) uye kukurudzira kudzorwa kusunungurwa.
2.3. Thermal kugadzikana
Hydroxypropyl methylcellulose ine kugadzikana kwakanaka kwekushisa, ichiibvumira kutsungirira huwandu hwakawanda hwekushisa hunosangana panguva yekugadzira maitiro. Ichi chivakwa chinofambisa kugadzirwa kweakasimba dosage mafomu, anosanganisira mahwendefa uye capsules.
3. Kushandiswa kwehydroxypropyl methylcellulose
3.1. Pharmaceutical industry
HPMC inoshandiswa zvakanyanya mundima yemishonga sechinhu chinobatsira mukugadzira mapiritsi uye ine kushandiswa kwakasiyana-siyana. Inoshanda sebhainda, inodzora kuparara uye kusunungurwa kwezvinhu zvinoshanda. Mukuwedzera, maitiro ayo ekugadzira firimu anoita kuti ave akakodzera kuvhara mapiritsi kuti ape chidziviriro chekudzivirira.
Mune oral liquid formulations, HPMC inogona kushandiswa seanomisa mumiriri, thickener, kana kugadzirisa viscosity. Kushandiswa kwaro mu ophthalmic solutions kunozivikanwa nokuda kwemucoadhesive properties, iyo inovandudza ocular bioavailability.
3.2. Indasitiri yezvokudya
Indasitiri yechikafu inoshandisa HPMC seyakakora uye gelling mumiriri mune zvakasiyana zvigadzirwa. Kugona kwayo kuumba gel akajeka uye kudzora viscosity kunoita kuti ive yakakosha mumashandisirwo akadai sososi, mapfekero uye confectionery. HPMC inowanzo kufarirwa pamusoro pechinyakare makobvu nekuda kwekuita kwayo kwakasiyana-siyana uye kushomeka kwesimba pane zvekunzwa zvivakwa zvechikafu.
3.3. Cosmetics uye zvigadzirwa zvekuchengeta munhu
Mukugadzirisa zvizorwa, HPMC inoshandiswa pakukora, kudzikamisa uye kugadzira firimu. Inowanzo kuwanikwa mumakirimu, lotions, uye zvigadzirwa zvekuchengetedza bvudzi. Iko kugona kwepolymer kuvandudza magadzirirwo uye kugadzikana kwemagadzirirwo anobatsira mukushandiswa kwayo kwakapararira muindasitiri yezvizoro.
3.4. Indasitiri yekuvaka
HPMC inoshandiswa muindastiri yekuvaka sechinhu chekuchengetedza mvura kune simende-based madhaka uye gypsum-based materials. Basa rayo ndere kusimudzira processability, kudzivirira kutsemuka, uye kunatsiridza kunamatira.
4. Mafungiro emitemo uye nhoroondo yekuchengeteka
4.1. Regulatory status
Hydroxypropyl methylcellulose inowanzo zivikanwa seyakachengeteka (GRAS) nemasangano anodzora akadai seUS Food and Drug Administration (FDA) uye European Food Safety Authority (EFSA). Iyo inosangana neakasiyana-siyana pharmacopoeial zviyero uye yakanyorwa mune avo akasiyana monographs.
4.2. Security overview
Seyakashandiswa zvakanyanya excipient, HPMC ine yakanaka kuchengetedza nhoroondo. Nekudaro, vanhu vane allergies anozivikanwa kune cellulose derivatives vanofanirwa kungwarira. Iko kusungirirwa kweHPMC mune fomula kwakanyatso kudzorwa kuti ive nechokwadi chekuchengetedza, izvo zvakakosha kuvanhu. Vagadziri vanoomerera kune yakasimbiswa nhungamiro.
5. Mhedziso uye tarisiro yeramangwana
Hydroxypropyl methylcellulose yakabuda seyakasiyana-siyana mubatsiri ane akawanda maapplication mumishonga, chikafu, cosmetic uye kuvaka maindasitiri. Musanganiswa wayo wakasarudzika wekunyungudika, viscosity control uye firimu-kugadzira zvivakwa zvinoita kuti ive yakakosha musanganiswa mune akawanda magadzirirwo.
Kuenderera mberi nekutsvagisa uye kusimukira mumunda wepolymer sainzi kunogona kutungamira kufambira mberi mukuita kweHPMC kusangana nezvinodiwa zveindasitiri. Sezvo kudiwa kweanodzorwa-kuburitswa maumbirwo uye kuvandudzwa kwechigadzirwa kuri kuramba kuchikura, hydroxypropyl methylcellulose inogona kuchengetedza basa rayo rakatanhamara semubatsiri ane hunyanzvi.
Nguva yekutumira: Jan-15-2024