Hydroxypropyl methylcellulose (HPMC) i polymer zvinhu zvinowanzoshandiswa mukugadzira mishonga.Nekuda kwehunhu hwayo hwakanaka hwemuviri nemakemikari, inoita basa rakakosha mukugadzira piritsi.HPMC inogona kushandiswa seyaimbova firimu, inodzorwa kuburitsa mumiririri, inonamira, thickener, zvichingodaro, ichipa mahwendefa maitiro akanaka uye basa.
1. Firimu yekare
Basa reHPMC seyaimbova firimu rinonyanya kuratidzwa mukuputira kwepamusoro kwemapiritsi ekuburitsa anodzorwa.Kuvhara kwehwendefa kunoitwa nechinangwa chekudzora kuburitswa kwezvinodhaka, kuchengetedza zvinodhaka kubva kune zvakatipoteredza pesvedzero, nekuvandudza kutaridzika kwezvinodhaka.Mukugadzirisa kusunungurwa kwegadziriro, iyo firimu yakaumbwa neHPMC inogona kugadzirisa kusunungurwa kwemishonga, kuve nechokwadi chokuti mishonga inosunungurwa mune dzimwe nzvimbo dzegastrointestinal turakiti, uye inobudirira kurapa kwakanakisisa.
Mechanism of action: Firimu rakaumbwa neHPMC firimu rekare rinogona kuwana kudzora kuburitswa kwezvinodhaka nekudzora kupinda kwezvinonyungudutsa uye kupera kwezvinodhaka.Ukobvu uye kuumbwa kwefirimu kunogona kugadzirisa chiyero chekuparara kunosangana nezvinodiwa zvekusunungurwa kwemishonga yakasiyana.
Impact: Mahwendefa anoshandisa HPMC semugadziri wekugadzira firimu anogona kunyungudika zvishoma nezvishoma mudumbu, kudzivirira kusunungurwa kwezvinodhaka kamwe kamwe, kunatsiridza kushandiswa kwezvinodhaka, uye kuderedza kushatirwa kwezvinodhaka kune gastrointestinal turakiti.
2. Controlled release agent
HPMC inowanzo shandiswa sematrix zvinhu mumapiritsi anodzorwa-anoburitswa kudzora kuburitswa kwemishonga nekugadzira gel barriers.Basa remushonga anodzorwa-anoburitsa ndere kuona kuti mushonga unoburitswa zvakaenzana mukati menguva yakatarwa kuchengetedza kugadzikana kwemushonga mumuviri, kuderedza huwandu hwenguva dzedosing, nekuvandudza kuterera kwemurwere.
Mechanism of action: Mune aqueous media, HPMC inogona kukurumidza hydrate uye kugadzira colloidal network chimiro, iyo inodzora kupararira uye kuburitswa kwemushonga.Kana piritsi racho rasangana nemvura, HPMC inotora mvura uye inozvimba kuita gel layer, iyo iyo mushonga unopararira kunze kwemuviri, uye chiyero chekuburitsa chinoenderana nekukora uye kuwanda kweiyo gel layer.
Impact: HPMC sechinhu chinodzorwa-chinoburitsa chinogona kudzikamisa chiyero chekuburitswa kwezvinodhaka, kuderedza kuchinjika kweropa remushonga, uye kupa yakagadzikana kurapa maitiro, kunyanya kumishonga yekurapa zvirwere zvisingaperi.
3. Binders
Mukuita kwekugadzirira piritsi, HPMC inowanzoshandiswa sebhainda kuwedzera simba remagetsi emapiritsi uye kuve nechokwadi chekuvimbika kwemapiritsi panguva yekuchengetedza, yekufambisa uye kutonga.
Mechanism of action: HPMC, sebhainda, inogona kuumba chisungo chakasimba pakati pezvidimbu, kuitira kuti hupfu kana zvidimbu zvinosungirirwa uye zvinogadzirwa kuva piritsi rakasimba.Iyi nzira inowanzoitwa kuburikidza nekunyorova kwehunyanzvi tekinoroji, uko HPMC inonyungudika mune aqueous mhinduro kugadzira viscous mhinduro, uye inoumba yakagadzikana piritsi mushure mekuoma.
Mhedzisiro: HPMC mabhainda anogona kuvandudza simba rekumanikidza uye kuoma kwemapiritsi, kuderedza njodzi yekuparara kana kupatsanuka, uye nekudaro kuvandudza kunaka nekugadzikana kwemapiritsi.
4. Makobvu
HPMC inogona zvakare kushandiswa seyakakora mukugadzirira kwemvura kugadzirisa iyo rheological ehupfumi yegadziriro uye kuwedzera viscosity.
Mechanism of action: HPMC ine high viscosity mumvura uye inogona zvinobudirira kuwedzera viscosity yemvura, kunatsiridza kuturika uye kugadzikana kwemushonga, uye kudzivirira sedimentation.
Mhedzisiro: Kuwedzera HPMC kumishonga yemvura kunogona kuvandudza kufanana kwemushonga, kuita kuti zvikamu zvemishonga zvigovane zvakaenzana mukugadzirira, uye kuve nechokwadi chemushonga nguva dzose.
Hunhu hweHydroxypropyl Methylcellulose
1. Physical uye Chemical Properties
HPMC is nonionic cellulose ether ine mvura yakanaka yekunyungudika uye kupisa kwemafuta.Inonyungudika nekukurumidza mumvura inotonhora kuti igadzire mhinduro yakajeka, nepo kana ichipisa, mhinduro inoshanduka kuita gel.
2. Biocompatibility
HPMC ine biocompatibility yakanaka uye chengetedzo, uye haikonzerese mhinduro yekudzivirira kana chepfu, saka inoshandiswa zvakanyanya muminda yemishonga neyekudya.
3. Kugadzikana kwezvakatipoteredza
HPMC ine kugadzikana kwakanaka kune zvakatipoteredza zvinhu senge tembiricha uye pH kukosha, uye haina kukurumidza kushatisa kana denaturation, iyo inovimbisa kugadzikana kwegadziriro yezvinodhaka panguva yekuchengetedza.
Mienzaniso yeHPMC Yekushandisa muMahwendefa
1. Kudzorwa Kuburitswa Mahwendefa
Semuenzaniso, mu nifedipine-yakagadziriswa mapiritsi anoshandiswa kurapa hypertension, HPMC inoshandiswa sematrix zvinhu kudzora kunonoka kusunungurwa kwemishonga, kuderedza kuwanda kwehutungamiri, nekuvandudza kutevedza kwevarwere.
2. Enteric-yakavharwa mapiritsi
Mumahwendefa ane enteric-akavharidzirwa eproton pump inhibitors (akadai seomeprazole), HPMC inoshanda semugadziri wekugadzira firimu kuchengetedza mushonga kubva pakuparadzwa negastric acid uye kuona kuti mushonga wacho wanyatsobudiswa muura.
3. Mahwendefa emuromo anokurumidza kupera
Mune mahwendefa emuromo anokurumidza kunyungudika ekurapa allergic rhinitis, HPMC inoshanda seyakakora uye inonamira kuti ipe kukurumidza kuparara uye yunifomu kuburitswa, kuvandudza kuravira uye kutora ruzivo rwemushonga.
Hydroxypropyl methylcellulose inoshandiswa zvakanyanya mukugadzirwa kwemapiritsi akasiyana-siyana nekuda kweakanakisa kugadzira firimu, kudzorwa kuburitswa, kunamatira uye kukora zvivakwa.HPMC haingogone kuvandudza zvimiro zvemuviri uye kugadzikana kwemapiritsi, asiwo optimize kurapa kwemishonga nekugadzirisa kuburitswa kwezvinodhaka.Nekuvandudzwa kwehunyanzvi hwekugadzira mishonga, kushandiswa kweHPMC kuchave kwakasiyana-siyana, zvichipa mikana yakawanda yekuvandudzwa kwegadziriro yemishonga.
Nguva yekutumira: Jun-27-2024