Chii chinonzi HPMC E3?

HPMC E3, kana hydroxypropyl methylcellulose E3, imhando ye cellulose ether iyo inowanzoshandiswa muindasitiri yemishonga sebhainda, thickener, uye inosimudzira kuburitsa mumiririri muhwendefa uye capsule formulations. Iyo isiri-ionic polymer iyo inotorwa kubva kune yakasikwa cellulose kuburikidza nekugadziriswa kwemakemikari,HPMC E3 viscosity renji ndeye 2.4-3.6 mPas.

Muindasitiri yemishonga, HPMC E3 inowanzoshandiswa seimwe nzira kune mamwe mabhandi, senge starch kana gelatin, nekuti inomera-yakavakirwa, yezvinomera. Inonyatsoenderana nemhando dzakasiyana-siyana dzinoshanda dzemishonga (APIs) uye dzinobatsira, zvichiita kuti zvive zvakasiyana-siyana uye zvinoshandiswa zvakanyanya mumishonga yakawanda yemishonga.

Imwe yemabhenefiti akakosha eHPMC E3 mumashandisirwo emishonga kugona kwayo kuita sebhainda. Kana ichishandiswa sebhainda, HPMC E3 inobatsira kubata chinhu chinoshanda uye zvimwe zvinokonzeresa pamwechete, kugadzira piritsi kana capsule. Izvi zvakakosha nekuti inovimbisa kuti piritsi kana capsule inochengetedza chimiro chayo uye kutendeseka mukati memaitiro ekugadzira uye panguva yekuchengetedza nekutakura.

HPMC E3 zvakare ine yakanakisa thickening zvivakwa, izvo zvinoita kuti zvive zvakakosha senge inomisa mumiriri mukuumbwa kwemvura. Inobatsira kudzivirira kugadzika kwechinhu chinoshanda uye zvimwe zvimedu mumvura, kuve nechokwadi chekuti kumiswa kunoramba kune homogeneous uye yunifomu mukati mesherufu yehupenyu hwechigadzirwa.

Kumwe kwakakosha kushandiswa kweHPMC E3 mumishonga ndiko kushandiswa kwayo seanogara achiburitsa mumiririri. Kana yakashandiswa mune iyi chiyero, HPMC E3 inobatsira kunonoka kuburitswa kwechinhu chinoshanda kubva pahwendefa kana capsule, zvichibvumira kudzora uye zvishoma nezvishoma kusunungurwa nekufamba kwenguva. Izvi zvinonyanya kukosha kune mishonga inoda kusunungurwa zvishoma nezvishoma uye zvishoma nezvishoma pane imwe nguva yakareba kuti ichengetedze maitiro avo ekurapa.

HPMC E3 inoshandiswawo sechinhu chinonamira mahwendefa nemakapisi. Kana yakashandiswa mune iyi chiyero, inobatsira kuchengetedza iyo inoshanda chimedu kubva pakuderedzwa nechiedza, unyoro, uye zvimwe zvinhu zvakatipoteredza, kuve nechokwadi chekuti mushonga unoramba uchishanda uye wakagadzikana muhupenyu hwayo hwesherufu. HPMC E3 machira anogona zvakare kushandiswa kuvhara kuravira uye kunhuhwirira kwechinhu chinoshanda, zvichiita kuti inakidze kuvarwere.

Pamusoro pekushandiswa kwayo mumapiritsi nemakapisi, HPMC E3 inoshandiswawo mune mamwe magadzirirwo emishonga, senge makirimu, gels, uye zvizoro. Mumagadzirirwo aya, anobatsira kuvandudza viscosity uye kugadzirwa kwechigadzirwa, zvichiita kuti zvive nyore kuisa kune ganda kana imwe nzvimbo yakakanganiswa. HPMC E3 inoshandiswawo se gelling agent mune topical formulations, kubatsira kuumba gel-kufanana kuwirirana kunopa kusunungurwa kwakasimba kwechinhu chinoshanda.

Iyo yakakurudzirwa dosage yeHPMC E3 mukugadzirwa kwemishonga inosiyana zvichienderana neiyo chaiyo mashandisirwo uye inodiwa zvimiro zvechigadzirwa chekupedzisira. Kazhinji, muyero we1% kusvika ku5% weHPMC E3 zvichienderana nehuremu hwese hwekugadzira inokurudzirwa.