Hydroxypropyl Methylcellulose (HPMC) yakakosha mvura-inonyungudika polima inoshandiswa zvakanyanya mumishonga, chikafu, machira, zvekuvakisa nezvimwe minda. Iyo mhinduro viscosity yeHPMC chinhu chakakosha chinokanganisa mashandiro ayo uye mashandisirwo, uye tembiricha ine chekuita kwakakura pakuona kweHPMC aqueous solution.
1. Viscosity maitiro eHPMC mhinduro
HPMC ndeye polymer zvinhu zvine thermally inodzoreredza dissolution zvivakwa. Kana HPMC yanyungudutswa mumvura, iyo yakaumbwa yemvura mhinduro inoratidza isiri-Newtonian fluid maitiro, kureva, mhinduro viscosity inoshanduka nekuchinja kweshear rate. Pakupisa kwakajairika, mhinduro dzeHPMC dzinowanzoita senge pseudoplastic fluid, kureva kuti, dzine viscosity yakakwira pane yakaderera shear rates, uye viscosity inodzikira sezvo shear rate inowedzera.
2. Mhedzisiro yekushisa pane viscosity yeHPMC mhinduro
Shanduko yetembiricha ine maviri makuru ekuita maitiro pane viscosity yeHPMC aqueous mhinduro: kuwedzera kupisa kwekufamba kwemamorekuru cheni uye shanduko mukudyidzana kwemhinduro.
(1) Kupisa kwekufamba kwecheni dzemamorekuru kunowedzera
Kana tembiricha ichiwedzera, kufamba kwemafuta eHPMC molecular chain kunowedzera, izvo zvinoita kuti ma hydrogen bond uye van der Waals masimba pakati pemamorekuru ashaye simba uye fluidity yemushonga kuwedzera. Iyo viscosity yemushonga inodzikira nekuda kwekuderedzwa kusungirirwa uye yemuviri kuyambuka-kubatanidza pakati pemaketani emamorekuru. Naizvozvo, HPMC aqueous mhinduro dzinoratidza yakaderera viscosity pane yakakwirira tembiricha.
(2) Shanduko mukudyidzana kwemhinduro
Kuchinja kwekushisa kunogona kukanganisa kunyungudika kwemamorekuru eHPMC mumvura. HPMC ipolymer ine thermogelling properties, uye kunyungudika kwayo mumvura kunoshanduka zvakanyanya nekushisa. Pakudziya kwakadzika, mapoka e-hydrophilic paHPMC molecular chain anoumba yakagadzikana mabhondi ehydrogen nemamorekuru emvura, nokudaro achichengetedza kunyungudika kwakanaka uye kupenya kwakanyanya. Nekudaro, kana tembiricha ichikwira kune imwe nhanho, iyo hydrophobic yekudyidzana pakati peHPMC molecular cheni inokwidziridzwa, zvichiita kuti paumbwe matatu-dimensional network chimiro kana gelation mune mhinduro, zvichiita kuti mhinduro viscosity iwedzere kamwe kamwe pasi pemamwe mamiriro. Ichi chiitiko chinonzi Icho chiitiko che "thermal gel".
3. Kuongorora kwekutarisa tembiricha paHPMC mhinduro viscosity
Ongororo dzekuyedza dzakaratidza kuti mukati meyakajairwa tembiricha (semuenzaniso, 20 ° C kusvika 40 ° C), viscosity yeHPMC aqueous mhinduro inodzikira zvishoma nezvishoma nekuwedzera tembiricha. Izvi zvinodaro nekuti tembiricha yepamusoro inowedzera kinetic simba remacheni echeni uye inoderedza kupindirana kweintermolecular, nekudaro ichidzikisa kukweshera kwemukati kwemhinduro. Nekudaro, kana tembiricha ichiramba ichiwedzera kusvika kune thermal gel point yeHPMC (kazhinji iri pakati pe60 ° C uye 90 ° C, zvichienderana nedhigirii rekutsiva uye huremu hwemamorekuru eHPMC), mhinduro viscosity inowedzera. Kuitika kwechiitiko ichi kune hukama nekubatanidzwa uye kuunganidzwa kweHPMC molecular cheni.
4. Ukama pakati tembiricha uye HPMC structural parameters
Iyo mhinduro viscosity yeHPMC haina kungobatwa nekushisa chete, asi zvakare yakanyatso hukama kune yayo molecular chimiro. Semuenzaniso, dhigirii rekutsiva (kureva, zviri mukati mehydroxypropyl uye methyl substituents) uye huremu hwemamolekyulu eHPMC zvine chekuita kwakakura pahunhu hwayo hwekupisa kwegel. HPMC ine yakakwira dhigirii yekutsiva inochengetedza yakaderera viscosity mune yakafara tembiricha siyana nekuda kweayo akawanda hydrophilic mapoka, nepo HPMC ine yakaderera dhigirii yekutsiva inogona kuumba thermal gels. Pamusoro pezvo, mhinduro dzeHPMC dzine huremu hwepamusoro huremu hunogona kuwedzera muviscosity pakupisa kwakanyanya.
5. Indasitiri uye Inoshanda Yekushandisa Kufunga
Mumashandisirwo anoshanda, akakodzera HPMC mhando dzinoda kusarudzwa zvinoenderana nemamiriro ekushisa chaiwo. Semuyenzaniso, munzvimbo dzepamusoro-tembiricha, HPMC ine tembiricha yepamusoro inopikisa inoda kusarudzwa kudzivirira kupisa gelation. Pasi pemamiriro ekushisa akadzika, iyo solubility uye viscosity kugadzikana kweHPMC inoda kutariswa.
Mhedzisiro yetembiricha pane viscosity yeHPMC aqueous solution ine yakakosha inoshanda kukosha. Mundima yemishonga, HPMC inowanzoshandiswa seyakagadziriswa-yakaburitswa gadziriro yemishonga, uye maitiro ayo eviscosity anokanganisa zvakananga kuburitswa kwemishonga. Muindasitiri yechikafu, HPMC inoshandiswa kuvandudza magadzirirwo uye kugadzikana kwezvigadzirwa, uye tembiricha yekutsamira kweiyo mhinduro viscosity inoda kugadziridzwa zvichienderana nekupisa kwekugadzirisa. Muzvigadzirwa zvekuvaka, HPMC inoshandiswa seyakakora uye inochengetedza mvura, uye hunhu hwayo hwe viscosity hunokanganisa kuita kwekuvaka uye kusimba kwezvinhu.
Mhedzisiro yekushisa pane viscosity yeHPMC aqueous solution inzira yakaoma inosanganisira kufamba kwekupisa kweketani yemamorekuru, kupindirana kwemhinduro, uye zvimiro zvepolymer. Pakazere, iyo viscosity yeHPMC aqueous mhinduro kazhinji inodzikira nekuwedzera tembiricha, asi mune mamwe tembiricha renji, thermal gelation inogona kuitika. Kunzwisisa hunhu uhu kune kwakakosha kutungamira kukosha kune inoshanda application uye process optimization yeHPMC.
Nguva yekutumira: Jul-10-2024