Hypromellose, inozivikanwawo se hydroxypropyl methylcellulose (HPMC), ndeye synthetic polymer inotorwa kubva ku cellulose. Inowanzoshandiswa mumaindasitiri akasiyana-siyana, kusanganisira mishonga, cosmetics, uye zvigadzirwa zvekudya. Mumushonga, hypromellose ine akati wandei maapplication nekuda kweiyo yakasarudzika zvivakwa.
1. Nhanganyaya yeHypromellose:
Hypromellose i hydrophilic polymer inoumba yakajeka, viscous mhinduro kana yakanyungudika mumvura. Inowanzoshandiswa sechinhu chisingaiti mukugadzirwa kwemishonga yekuvandudza zvigadzirwa zvakadai se viscosity, kugadzikana, uye bioavailability. Hypromellose inoshandiswa zvakanyanya mumuromo yakasimba dosage mafomu, ophthalmic kugadzirira, uye topical formulations.
2. Pharmaceutical Applications:
a. Oral Solid Dosage Mafomu:
Mumishonga yemuromo, hypromellose inoshandisa zvinangwa zvakasiyana:
Binder: Inobatsira kusunga mishonga inoshanda yemishonga (APIs) pamwe chete kugadzira mapiritsi kana capsules.
Disintegrant: Hypromellose inofambisa kuputsika kwemapiritsi kana macapsules mudumbu remukati, kukurudzira kuburitswa kwezvinodhaka uye kutorwa.
Firimu Rakamboita: Inoshandiswa kugadzira firimu rakatetepa, rinodzivirira rakanamira pamahwendefa ekudzorwa-kuburitsa magadzirirwo kana kuvhara zvinonaka zvisingafadzi.
b. Kugadzirira kweOphthalmic:
Mune madonhwe eziso uye zvizoro, hypromellose inoshanda se:
Viscosity Modifier: Iyo inowedzera viscosity yemadonhwe eziso, ichipa nguva yakareba yekuonana neyemeso uye inosimudzira kuendesa zvinodhaka.
Lubricant: Hypromellose inozora pamusoro peziso, kubvisa kuoma uye kusagadzikana kunoenderana nemamiriro ezvinhu senge yakaoma eye syndrome.
c. Topical Formulations:
Mune zvigadzirwa zvemusoro senge makirimu, gels, uye mafuta ekuzora, hypromellose inoshanda se:
Gelling Agent: Inobatsira kuumba gel-kufanana kuwirirana, kuvandudza kupararira uye kunamatira kwechigadzirwa paganda.
Moisturizer: Hypromellose inochengetedza hunyoro, ichinyorovesa ganda uye kudzivirira kurasikirwa kwemvura.
3. Nzira Yekuita:
Hypromellose maitiro ekuita zvinoenderana nekushandiswa kwayo:
Oral Administration: Kana ikadyiwa, hypromellose inozvimba pakubata nemvura mudumbu remukati, ichikurudzira kuparara uye kuparara kweiyo dosage fomu. Izvi zvinobvumira kusunungurwa kunodzorwa uye kutorwa kwemishonga.
Kushandisa Ophthalmic: Mumadonhwe eziso, hypromellose inowedzera viscosity yemhinduro, kuwedzera nguva yekuonana kwemaziso uye kuwedzera kunyura kwezvinodhaka. Inopawo lubrication kuti ibvise kuoma uye kutsamwa.
Topical Application: Senge gelling agent, hypromellose inoumba chidziviriro paganda, kudzivirira kurasikirwa kwemwando uye kufambisa kunyudzwa kwezvinhu zvinoshanda.
4. Nhoroondo Yekuchengetedza:
Hypromellose inowanzoonekwa yakachengeteka kuti ishandiswe mumishonga, zvizorwa, uye zvigadzirwa zvekudya. Haina-chepfu, isingatsamwisi, uye haina-allergenic. Nekudaro, vanhu vanozivikanwa hypersensitivity kune cellulose derivatives vanofanirwa kudzivirira zvigadzirwa zvine hypromellose. Pamusoro pezvo, madonhwe eziso ane hypromellose anogona kukonzera kudzima kwechinguvana kwekuona nekukurumidza mushure mekutonga, izvo zvinowanzogadzirisa nekukurumidza.
5. Zvingangoitika Zvikonzero:
Kunyange zvazvo hypromellose ichinyatsobvumirwa nevanhu vakawanda, mamwe maitiro asingawanzoitiki anogona kuitika, kusanganisira:
Allergic Reactions: Muvanhu vane hanya, maitiro e hypersensitivity akadai sekukwenya, kutsvuka, kana kuzvimba anogona kuitika kana wasangana nezvigadzirwa zvine hypromellose.
Ocular Irritation: Madonhwe eziso ane hypromellose anogona kukonzera kutsamwisa, kupisa, kana kuruma pakuisa.
Kuvhiringidza kweGastrointestinal: Muzviitiko zvisingawanzoitiki, mishonga yemuromo ine hypromellose inogona kukonzera zviratidzo zvepamuviri zvakadai sekusvotwa, kuputika, kana manyoka.
Hypromellose i polymer inoshanda zvakasiyana-siyana ine akasiyana emishonga ekushandisa, kusanganisira yemuromo yakasimba dosage mafomu, kugadzirira kwemaziso, uye maumbirwo emusoro. Inosimudzira hunhu hwechigadzirwa senge viscosity, kugadzikana, uye bioavailability, kuvandudza kuendesa zvinodhaka uye kutevedzera kwemurwere. Kunyangwe kushandiswa kwayo kwakapararira uye kazhinji yakanakira kuchengetedza chimiro, vanhu vanozivikanwa hypersensitivity kune cellulose zvinobuda vanofanira kushandisa hypromellose-ine zvigadzirwa nekuchenjerera. Pakazere, hypromellose inoita basa rakakosha mukugadzirwa kwemazuva ano kwemishonga, zvichibatsira mukubudirira uye kuchengetedzeka kwemishonga uye zvigadzirwa zvehutano.
Nguva yekutumira: Mar-01-2024