Hydroxypropylmethylcellulose (HPMC) i polymer inoshanda yakawanda inotorwa kubva muselulosi iyo inoshandiswa zvakanyanya mumaindasitiri akasiyana siyana nekuda kwekusiyana kwayo. Mushonga wacho unogadzirwa kuburikidza nenhevedzano yemakemikari ekuchinja kune cellulose, yakasikwa polymer inowanikwa muchirimwa sero madziro.
raw material:
Kunobva: Cellulose ndiyo huru mbishi zvinhu zveHPMC, iyo yakawanda muzvisikwa uye inotorwa kubva muzvirimwa. Wood pulp uye machira ekotoni ndiwo anonyanya kuwanikwa e cellulose.
Kuzviparadzanisa nevamwe: Maitiro ekubvisa anosanganisira kuputsa madziro esero rechirimwa uye kupatsanura ma cellulose fiber. Nzira dzakasiyana-siyana dzemakemikari uye michina inogona kushandiswa kune chinangwa ichi.
Propylene oxide:
Kunobva: Propylene oxide ndeye organic compound inotorwa kubva petrochemical sources.
Basa: Propylene oxide inoshandiswa kuunza mapoka ehydroxypropyl mumamorekuru e cellulose panguva yekugadzira, kuwedzera kunyungudika kwemvura uye kushandura hunhu hweiyo HPMC inoguma.
Methyl chloride:
Kwakabva: Methyl chloride ndeye chlorinated hydrocarbon inogona kugadzirwa kubva kumethanol.
Basa: Methyl chloride inoshandiswa kuunza methyl mapoka mu cellulose mamorekuru, ayo anobatsira kune yakazara hydrophobicity yeHPMC.
Sodium hydroxide (NaOH):
Kwakabva: Sodium hydroxide, inozivikanwawo se caustic soda, inzvimbo yakasimba uye inowanikwa mune zvekutengesa.
Basa: NaOH inoshandiswa kukonzeresa maitiro uye kugadzirisa pH kukosha kweiyo reaction musanganiswa panguva ye synthesis process.
Synthesis:
Iyo synthesis yeHPMC inosanganisira akati wandei matanho, uye maitiro ekuita anogona kupfupikiswa sezvinotevera:
Alkalizing:
Cellulose inobatwa ne sodium hydroxide kugadzira alkaline cellulose.
Alkali cellulose inobva yaitwa nepropylene oxide kuunza mapoka ehydroxypropyl.
Methylation:
Hydroxypropylated cellulose inozoitwa zvakare nemethyl chloride kuunza methyl mapoka.
Iyi nhanho inopa iyo polymer kuwedzera kugadzikana uye hydrophobicity.
Neutralization uye kusefa:
The reaction mix was neutralized kubvisa yakawandisa base.
Kusefa kwakaitwa kuti kutsaure iyo yakagadziridzwa cellulose.
Kuwacha nekuomesa:
Chigadzirwa chakapatsanurwa chinogezwa chobva chaomeswa kuwana hydroxypropyl methylcellulose muupfu kana granular fomu.
Hunhu solubility yeHPMC:
HPMC inonyungudika mumvura uye kunyungudika kwayo kunogona kugadziridzwa zvichienderana nedhigirii rekutsiva hydroxypropyl uye methyl mapoka.
Kukwanisa kugadzira firimu:
HPMC inoumba anochinjika, akajeka mafirimu akakodzera kunyorera mumaindasitiri emishonga uye ezvekudya.
Viscosity:
Iyo viscosity yeHPMC mhinduro inogona kudzorwa uye inowanzoshandiswa seyakakora uye gelling mumiriri mune akasiyana mafomati.
Thermal gelation:
Mamwe mamakisi eHPMC anoratidza thermogelling zvivakwa, achigadzira gel kana yapiswa uye ichidzokera kune mhinduro kana yatonhodzwa.
Chiitiko chepamusoro:
HPMC inogona kushandiswa se surfactant, uye basa rayo repamusoro rinokanganiswa nehuwandu hwekutsiva.
Mishonga inoshandiswa yeHPMC:
HPMC inoshandiswa zvakanyanya mukugadzira mishonga semabinders, disintegrants, uye anodzorwa kuburitsa maajenti mumahwendefa nemakapisi.
Indasitiri yekuvaka:
Muchikamu chekuvaka, HPMC inoshandiswa seyakakora mune zvigadzirwa-samende senge madhaka uye anonamira mataira.
indasitiri yezvekudya:
HPMC inoshandiswa muindasitiri yechikafu seyakakora, emulsifier uye inodzikamisa mune zvakasiyana zvigadzirwa, zvinosanganisira sosi, madhiri uye ice cream.
Zvigadzirwa zvekuchengeta wega:
Muzvizora uye zvigadzirwa zvekuchengeta munhu, HPMC inoshandiswa mukugadzira senge makirimu, lotions uye shampoos nekuda kwekukora uye kudzikamisa zvivakwa.
Paints uye Coatings:
HPMC inowedzerwa kupendi uye machira kudzora viscosity, kunatsiridza zvivakwa zvekushandisa uye kuwedzera firimu-kuumba zvivakwa.
Ophthalmic Solutions:
HPMC inoshandiswa mumadonhwe eziso uye misodzi yekugadzira nekuda kweiyo biocompatibility uye mucoadhesive zvivakwa.
mukupedzisa:
Hydroxypropylmethylcellulose (HPMC) inoshamisa polymer yakagadzirwa kubva kune inovandudzwa resource cellulose. Hunhu hwayo hunoshanda uye huwandu hwakawanda hwekushandisa hunoita kuti ive chinhu chakakosha mumaindasitiri akasiyana, kubva kumishonga kusvika pakuvaka uye chikafu. Nekungwarira kusarudzwa kwezvinhu zvakasvibirira uye kutonga kweiyo synthesis paramita, HPMCs ine yakagadziridzwa zvivakwa inogona kugadzirwa kuti isangane nezvinodiwa chaizvo zvekushandisa kwakasiyana. Sezvo tekinoroji uye zvinodiwa zvichiramba zvichishanduka, HPMC ingangoramba iri mutambi akakosha mukuvandudza uye kusimudzira chigadzirwa kusimudzira mumaindasitiri.
Nguva yekutumira: Zvita-18-2023