Hydroxypropyl methylcellulose (HPMC) inokosha cellulose ether, inoshandiswa zvakanyanya mukuvaka, mishonga, zvokudya, makemikari ezuva nezuva uye mamwe minda. HPMC ipolymer inonyungudika nemvura inowanikwa nekugadziriswa kwemakemikari echisikigo cellulose, ine akawanda akanakisa emuviri nemakemikari zvimiro.
1. Zvinhu zvemuviri
Chitarisiko uye morphology: HPMC kazhinji ichena kana kuti yero hupfu, isinganhuhwi, isinganakidze, uye ine mvura yakanaka. Inogona kuumba firimu reyunifomu kana gel kuburikidza nenzira dzakasiyana-siyana dzekugadzirisa, izvo zvinoita kuti iite zvakanaka mumashandisirwo akawanda.
Solubility: HPMC inonyungudika nyore mumvura inotonhora, asi isinganyungudika mumvura inopisa. Kana tembiricha yasvika pane imwe nhanho (kazhinji 60-90 ℃), HPMC inorasikirwa nekunyungudika mumvura uye inogadzira gel. Ichi chivakwa chinoigonesa kupa kukora mhedzisiro kana yapiswa, uye kudzokera kune yakajeka aqueous mhinduro mamiriro mushure mekutonhora. Pamusoro pezvo, HPMC inonyungudika zvishoma muorganic solvents senge ethanol.
Viscosity: Iyo viscosity yeHPMC mhinduro ndeimwe yeayo akakosha emuviri zvimiro. Iyo viscosity inoenderana nehuremu hwayo hwemamorekuru uye kusangana kwemhinduro. Kazhinji kutaura, kukura kwehuremu hwema molecular, kunowedzera viscosity yemhinduro. HPMC ine zvakasiyana-siyana zveviscosity uye inogona kugadziriswa maererano nezvinodiwa zvekushandisa, izvo zvinoita kuti ishandiswe zvakanyanya mukuvaka, mishonga, makemikari ezuva nezuva uye mamwe maindasitiri.
Firimu-yekugadzira chivakwa: HPMC ine yakanakisa firimu-yekugadzira chivakwa. Inogona kuumba firimu rakajeka uye rakaoma mushure mekunyunguduka mumvura kana organic solvents. Iyo firimu ine mafuta akanaka uye kusagadzikana kwemafuta, saka inowanzoshandiswa sechinhu chekuputira muminda yezvokudya nemishonga. Mukuwedzera, HPMC firimu zvakare ane yakanaka mwando kuramba uye anogona zvinobudirira kudzivirira mukati zvinhu kubva mwando.
Thermal kugadzikana: HPMC ine yakanaka yekudziya kugadzikana. Kunyangwe ichirasikirwa nekunyungudika uye ichigadzira gel pakupisa kwepamusoro, ine yakanakisa kugadzikana kwekupisa munzvimbo yakaoma uye inokwanisa kumirisana nekushisa kwakanyanya kwekugadzirisa pasina kuora. Ichi chimiro chinochipa mukana wepamusoro-tembiricha yekugadzirisa.
2. Chemical properties
Kugadzikana kwemakemikari: HPMC ine kugadzikana kwakanaka kwemakemikari patembiricha yekamuri uye yakatsiga kune acid, alkali nemunyu. Naizvozvo, mune akawanda magadzirirwo emakemikari kana magadzirirwo masisitimu, HPMC inogona kuvapo seyakagadzikana uye haisi nyore kuita kemikari nezvimwe zvinongedzo.
pH kugadzikana: HPMC inoramba yakagadzikana muhuwandu hwepH 2-12, iyo inoita kuti ishandiswe munzvimbo dzakasiyana dzepH. HPMC haizoitirwe hydrolysis kana kuderedzwa pasi pe acidic kana alkaline mamiriro, izvo zvinoita kuti ishandiswe zvakanyanya mukudya, mushonga, uye zvizorwa.
Biocompatibility uye isiri-chepfu: HPMC ine biocompatibility yakanaka uye inogona kushandiswa zvakachengeteka mumishonga, chikafu uye mamwe minda ane zvakanyanyisa zvinodiwa pahutano hwevanhu. HPMC haina chepfu uye haina kushatirisa, uye haizoputswe kuita mamorekuru madiki nema enzymes ekugaya mumuviri, saka inogona kushandiswa seyakadzora inoburitsa mumiririri wezvinodhaka kana thickener chikafu.
Kemikari kugadziridzwa: HPMC ine nhamba huru yemapoka ehydroxyl mune yayo molecular chimiro, iyo inogona kuvandudzwa kana kupihwa mitsva mitsva nekuwedzera makemikari shanduko. Semuyenzaniso, nekuita nealdehydes kana organic acids, HPMC inogona kugadzirira zvigadzirwa zvine kupisa kwakanyanya kana kusamira kwemvura. Pamusoro pezvo, HPMC inogona zvakare kusanganiswa nemamwe mapolymer kana additives kuti igadzire zvinhu zvakaumbwa kuti isangane nezvinodiwa zvekushandisa chaiko.
Moisture adsorption: HPMC ine yakasimba hygroscopicity uye inogona kutora mwando kubva kumhepo. Ichi chivakwa chinobvumira HPMC kukora uye kugadzirisa humidity yechigadzirwa mune mamwe maapplication. Nekudaro, mune dzimwe nguva, kunyura kwakanyanyisa kwehunyoro kunogona kukanganisa kugadzikana kwechigadzirwa, saka mhedzisiro yehunyoro hwepakati pakuita kweHPMC inofanirwa kutariswa kana uchiishandisa.
3. Minda yekushandisa uye zvakanakira
Nekuda kwekusiyana kwayo kwemuviri uye makemikari zvimiro, HPMC ine huwandu hwakasiyana hwekukosha kwekushandisa muminda yakawanda. Semuyenzaniso, mumunda wekuvaka, HPMC inoshandiswa seyakakora uye inochengeta mvura mumiriri wesimende-based zvinhu kuvandudza kuvaka uye kusimba kwezvivakwa zvekuvaka; mumunda wemishonga, HPMC inowanzoshandiswa sepiritsi inonamira, inodzorwa yekuburitsa mumiririri, uye capsule coating zvinhu; mumunda wekudya, inoshandiswa semukobvu, emulsifier, uye stabilizer kunatsiridza kuravira uye kuumbwa kwechikafu.
Hydroxypropyl methylcellulose inotora basa risingadzokerike mumaindasitiri mazhinji nekuda kwekunaka kwayo kwemuviri nemakemikari zvimiro. Kuita kwayo kwakatanhamara mukunyungudika kwemvura, firimu-kugadzira zvivakwa, kugadzikana kwemakemikari, nezvimwe zvinoita kuti HPMC ive yakakosha yakawanda inoshanda zvinhu muindasitiri uye hupenyu hwezuva nezuva.
Nguva yekutumira: Aug-22-2024