Hydroxypropyl methylcellulose (HPMC, Hydroxypropyl Methylcellulose) inokosha cellulose ether, inoshandiswa zvakanyanya mukuvaka, mishonga, zvokudya uye mamwe minda, uye inonyanya kushandiswa mukuvaka zvinhu. Kuchengetwa kwemvura kweHPMC ndechimwe chezvinhu zvayo zvakakosha uye inoita basa rakakosha mukubudirira kwezvizhinji zvekushandisa. Zvinhu zvinokanganisa kuchengetwa kwemvura kweHPMC zvinosanganisira mamorekuru chimiro, dhigirii rekutsiva, huremu hwemamorekuru, solubility, ambient tembiricha, zvinowedzera, nezvimwe.
1. Chimiro chemolecular
HPMC ndeye cellulose derivative ine mamorekuru maitiro ane zvakakosha pakuchengetedza mvura. Iyo molecular chimiro cheHPMC ine hydrophilic hydroxyl (-OH), lipophilic methyl (-CH₃) uye hydroxypropyl (-CH₂CHOHCH₃). Kuwanda uye kugoverwa kweaya hydrophilic uye lipophilic mapoka ane zvakanangana nekukanganisa kwekuchengetedza mvura kuita kweHPMC.
Basa remapoka ehydroxyl: Mapoka eHydroxyl mapoka ehydrophilic anogona kuumba mahydrogen bond nemamorekuru emvura, zvichibatsira kuvandudza kuchengetwa kwemvura kweHPMC.
Basa remamethyl uye hydroxypropyl mapoka: Aya mapoka ari hydrophobic uye anogona kukanganisa kunyungudika uye gelation tembiricha yeHPMC mumvura, nekudaro ichikanganisa mashandiro ekuchengetedza mvura.
2. Dhigirii rekutsiva
Iyo dhigirii yekutsiva (DS) inoreva huwandu hweavhareji yemapoka ehydroxyl akatsiviwa mumamorekuru ecellulose. Kune HPMC, dhigirii rekutsiva methoxy (-OCH₃) uye hydroxypropoxy (-OCH₂CHOHCH₃) rinowanzo kunetseka, ndiko kuti, dhigirii rekutsiva methoxy (MS) uye dhigirii rekutsiva hydroxypropoxy (HP):
Yakakwira dhigirii yekutsiva: Iyo yakakwirira dhigirii yekutsiva, iyo yakawanda hydrophilic mapoka HPMC ine, uye ne theoretically kuchengetwa kwemvura kuchavandudzwa. Nekudaro, yakawandisa dhigirii yekutsiva inogona kutungamirira mukunyungudika kwakanyanya, uye mhedzisiro yekuchengeta mvura inogona kuderedzwa.
Yakaderera dhigirii yekutsiva: HPMC ine yakaderera dhigirii yekutsiva ine kushomeka kwekunyungudika mumvura, asi network yakaumbwa inogona kunge yakagadzikana, nekudaro ichichengetedza zvirinani kuchengetwa kwemvura.
Kugadzirisa dhigirii rekutsiva mukati meimwe nhanho kunogona kukwidziridza kuchengetwa kwemvura kweHPMC. Madhigirii ekutsiva akajairika anowanzo 19-30% yemethoxy uye 4-12% yehydroxypropoxy.
3. Kurema kwema molecular
Huremu hwemamorekuru hweHPMC hune chekuita nekuchengetedza kwayo mvura:
High molecular uremu: HPMC ine huremu hwema molecular huremu hurefu hwemacheni uye inoumba denser network chimiro, iyo inogona kugamuchira uye kuchengetedza mvura yakawanda, nokudaro inovandudza kuchengetedza kwemvura.
Low molecular uremu: HPMC ine yakaderera molecular huremu ine mapfupi mamorekuru uye zvishoma shoma mvura kuchengetedza simba, asi ine yakanaka solubility uye yakakodzera maapplication anoda kukurumidza kuparadzwa.
Kazhinji, huwandu hwehuremu hweHPMC hunoshandiswa mukuvaka zvinhu kubva pa80,000 kusvika 200,000.
4. Solubility
Iyo solubility yeHPMC inokanganisa zvakananga kuchengetwa kwayo kwemvura. Kunyungudika kwakanaka kunobatsira HPMC kuti iparadzwe zvizere mumatrix, nekudaro ichigadzira yunifomu yekuchengetedza mvura. Solubility inokonzerwa ne:
Dissolution tembiricha: HPMC inonyungudika zvishoma nezvishoma mumvura inotonhora, asi inonyungudika nekukurumidza mumvura inodziya. Nekudaro, tembiricha yakanyanya kukonzeresa HPMC kunyungudika zvakanyanya, zvichikanganisa chimiro chekuchengetedza mvura.
pH kukosha: HPMC inonzwisisa pH kukosha uye ine zvirinani solubility munzvimbo dzakarerekera kana dzisina kusimba acidic. Inogona kuderedza kana kuderedza kunyungudika pasi peyakanyanya pH kukosha.
5. Ambient tembiricha
Tembiricha ine simba rakakura pakuchengetedza mvura kweHPMC:
Tembiricha yakaderera: Pakudziya kwakadzika, kunyungudika kweHPMC kunoderera, asi viscosity yakakwira, iyo inogona kuumba yakagadzikana inochengetedza mvura.
Tembiricha yepamusoro: Tembiricha yepamusoro inomhanyisa kuparara kweHPMC, asi inogona kukonzera kukuvadzwa kweiyo inochengetedza mvura chimiro uye kukanganisa mhedzisiro yayo yekuchengetedza mvura. Kazhinji, kuchengetwa kwemvura kwakanaka kunogona kuchengetedzwa pasi pe40 ℃.
6. Zvinowedzera
HPMC inowanzo shandiswa pamwe chete nezvimwe zvinowedzera mukushandisa zvinoshanda. Izvi zvinowedzera zvinogona kukanganisa kuchengetwa kwemvura kweHPMC:
Plasticizers: senge glycerol uye ethylene glycol, iyo inogona kuvandudza kushanduka uye kuchengetwa kwemvura kweHPMC.
Fillers: zvakadai segypsum uye quartz powder, zvichakanganisa kuchengetedza kwemvura kweHPMC uye kuchinja kupararira kwayo uye kuparara kwemaitiro kuburikidza nekubatana neHPMC.
7. Mamiriro ekushandisa
Kuita kwekuchengetedza mvura kweHPMC kuchakanganiswawo pasi pemamiriro akasiyana ekushandisa:
Mamiriro ekuvaka: senge nguva yekuvaka, humidity kwezvakatipoteredza, nezvimwe zvinokanganisa kuchengetedza kwemvura kweHPMC.
Nhamba yekushandisa: Huwandu hweHPMC hunokanganisa zvakananga kuchengetedza kwemvura. Kazhinji, HPMC ine yakakwira dosi inoratidza zvirinani kuchengetedza mvura mumatope esimende uye zvimwe zvinhu.
Pane zvinhu zvakawanda zvinokanganisa kuchengetwa kwemvura kweHPMC, kusanganisira chimiro chayo chemolecular, dhigirii rekutsiva, uremu hwemamorekuru, solubility, tembiricha yeambient, additives, uye mamiriro chaiwo ekushandisa. Munguva yekushanda kwekushandisa, nekusarudza zvine musoro nekugadzirisa zvinhu izvi, mashandiro ekuchengetedza mvura eHPMC anogona kuvandudzwa kuti asangane nezvinodiwa zveminda dzakasiyana.
Nguva yekutumira: Jun-24-2024