Hydroxypropyl Methylcellulose (HPMC) is nonionic cellulose ether inoshandiswa zvakanyanya mumaindasitiri akadai sekuvaka, mushonga, chikafu, zvizorwa uye machira. Kusarudzika kwayo kunobva kune yakasarudzika physicochemical zvimiro senge kukora, kubatana, kugadzira firimu, kuchengetwa kwemvura uye lubrication. Iwo magiredhi akasiyana eHPMC anonyanya kuiswa zvichienderana nedhigirii ravo rekutsiva (DS) uye methoxy uye hydroxypropyl zvemukati, mukuwedzera kune yavo viscosity, particle size uye kuchena. Aya magiredhi akasiyana eHPMC ane akasiyana ekushandisa maitiro uye mashandisiro.
1. Methoxy content uye hydroxypropyl content
Iyo methoxy uye hydroxypropyl inotsiva zvemukati zveHPMC ndicho chinhu chakakosha chinotaridza kuita kwayo. Kazhinji kutaura, methoxy yemukati yeHPMC iri pakati pe19% ne30%, uye iyo hydroxypropyl yemukati iri pakati pe4% ne12%. HPMC ine yakakwira methoxy yemukati kazhinji ine zvirinani solubility uye firimu-kugadzira zvimiro, nepo HPMC ine yakakwira hydroxypropyl yemukati ine elasticity iri nani uye kuchengetedza mvura. Aya paramita anokanganisa zvakananga kushandiswa kweHPMC. Semuenzaniso, muindasitiri yekuvaka, yakakwira methoxy yemukati inobatsira kuvandudza kuchengetwa kwemvura uye kuita kwekuvaka kwedhaka; mumunda wemishonga, yakakwira hydroxypropyl yemukati inobatsira kuvandudza kunamatira uye kuburitsa maitiro emishonga.
2. Viscosity giredhi
HPMC inogona kupatsanurwa kuita yakaderera viscosity, yepakati viscosity uye yakakwirira viscosity mamakisi maererano viscosity yemhinduro yayo. Viscosity chinhu chakakosha chemuviri cheHPMC, chinowanzoyerwa neinooneka viscosity ye2% mhinduro mumilliPascal seconds (mPa.s).
Low viscosity HPMC (senge 5 mPa.s kusvika 100 mPa.s): Rudzi urwu rweHPMC runowanzo shandiswa mumaapplication anoda kuderera kukora mhedzisiro, senge madonhwe emeso, sprays uye cosmetics. Mune izvi zvinoshandiswa, yakaderera viscosity HPMC inogona kupa yakanaka fluidity uye yunifomu kugovera.
Medium viscosity HPMC (eg 400 mPa.s kusvika 2000 mPa.s): Medium viscosity HPMC inowanzoshandiswa mukuvaka zvinhu, emulsion uye zvinonamira kuti zvipe zvine mwero thickening mhedzisiro, iyo inogona kuenzanisa kuita kwekuvaka uye kusimba kwemuviri kwechigadzirwa chekupedzisira.
High viscosity HPMC (eg 4000 mPa.s kusvika 200,000 mPa.s): High viscosity HPMC inonyanya kushandiswa mumaapplication anoda kukora zvakanyanya, sedhaka, putty, mataira anonamira uye mabhanhire. Mune zvigadzirwa izvi, iyo yakakwira viscosity yeHPMC inobatsira kuvandudza kuchengetwa kwayo kwemvura, anti-sagging uye kusimba kwekubatana.
3. Kukura kwechikamu
Iyo particle size yeHPMC inokanganisawo mashandisiro ayo. Kazhinji kutaura, HPMC inogona kukamurwa kuita zvidimbu zvakakoshera uye zvimedu zvakanaka. Coarse particle HPMC inowanzo shandiswa mumashandisirwo anoda kukurumidza kunyungudika kana kupararira, nepo chidimbu cheHPMC chakakodzera zvigadzirwa zvine zvakakwirira zvinodikanwa zvekutaridzika kana zvinoda mamwe mayunifomu kugovera.
Coarse-grained HPMC: HPMC ine zvimedu zvakakura ine kukurumidza kunyungudika mudhaka yakaoma-yakasanganiswa nemimwe minda, uye inogona kukurumidza kuumba yunifomu mhinduro, nekudaro ichivandudza kugadzirwa kwehunyanzvi.
Fine-grained HPMC: Fine-grained HPMC inonyanya kushandiswa mumaindasitiri akadai sependi, machira uye zvizorwa. Inogona kuumba imwe yunifomu yefirimu layer panguva yekushandisa, kuvandudza kupenya uye kunzwa kwechigadzirwa.
4. Kuchena uye mamakisi akakosha
Zvinoenderana nezvinodiwa zvakasiyana zvekushandisa, HPMC inogona zvakare kucheneswa kana kushanda. HPMC ine kuchena kwepamusoro inowanzo shandiswa mumaindasitiri emishonga uye ezvekudya kuve nechokwadi chekuchengetedza uye biocompatibility yechigadzirwa. Mukuwedzera, kune mamwe maHPMC ane mabasa anokosha, akadai se-cross-linked HPMC, HPMC inobatwa nepamusoro-soro, nezvimwewo. Aya magiredhi anokosha eHPMC anogona kupa kukwirira kwekuputika kwepamusoro, kusimba kwemafirimu ekugadzira zvinhu kana kuti asidi iri nani uye alkali kuramba.
Pharmaceutical giredhi HPMC: Pharmaceutical giredhi HPMC ine kuchena kwepamusoro uye inokodzera mahwendefa, capsules uye inosimudzira-kuburitswa gadziriro, iyo inogona zvakanyanya kuvandudza kuburitswa kweyero uye kugadzikana kwezvinodhaka.
Chikafu giredhi HPMC: Chikafu giredhi HPMC inoshandiswa sechikafu thickener, stabilizer uye emulsifier kuve nechokwadi chekuchengetedza uye kuravira kwechikafu.
Industrial giredhi HPMC: HPMC inoshandiswa mukuvaka, machira uye mamwe minda inogona kunge iine hushoma hwetsvina, asi inogona kupa hupfumi hwepamusoro uye kuita kwakanaka kwekugadzirisa.
5. Minda yekushandisa uye kusarudzwa
Akasiyana mamakisi eHPMC anoshandiswa zvakanyanya mukuvaka, mushonga, chikafu, zvizorwa uye mamwe minda. Pakusarudza iyo yakakodzera HPMC giredhi, zvinhu zvakaita seviscosity, substituent content, particle size uye kuchena kunoda kutariswa zvinoenderana nezvinodiwa zvemashandisirwo chaiwo.
Munda wekuvaka: Muzvivakwa zvekuvaka, HPMC inonyanya kushandiswa seyakakora, inochengetedza mvura uye bhainda. Kune maapplication akadai sedhaka rakaoma uye matani anonamira, chakakosha kusarudza HPMC ine viscosity yakakodzera uye kuchengetedza mvura.
Pharmaceutical field: Mukugadzirira kwemishonga, HPMC inoshandiswa se capsule shell material, tablet coating and adhesive. Izvo zvinodikanwa kusarudza HPMC mamakisi ane akakodzera kuburitsa zvinodhaka kuita uye biocompatibility.
Chikafu uye zvekuzora: Muindasitiri yechikafu uye yezvizorwa, HPMC inoshandiswa seyakakora uye inodzikamisa, uye kuchena kwayo uye kuchengetedzeka ndizvo zvinonyanya kufunga.
Akasiyana mamakisi eHydroxypropyl Methylcellulose (HPMC) ane zvawo zvakanakira uye anoshanda masikopu mumashandisirwo. Kunzwisisa uye kusarudza iyo yakakodzera HPMC giredhi inogona zvinobudirira kuvandudza mashandiro uye kunaka kwechigadzirwa uye kusangana nezvinodiwa zveakasiyana maindasitiri nevatengi zvigadzirwa.
Nguva yekutumira: Aug-21-2024