Hydroxypropyl methylcellulose (HPMC) ipolymer inoshandiswa zvakasiyana-siyana inoshandiswa mumaindasitiri akasiyana siyana anosanganisira zvemishonga, zvekuvaka, chikafu, uye zvekuzora. Iyo inotorwa selulosi inoratidza huwandu hwezvivakwa zvinoenderana negiredhi rayo chairo. Akasiyana mamakisi eHPMC anonyanya kusiyaniswa neavo viscosity, dhigirii rekutsiva, saizi yechikamu, uye chinangwa chekushandisa.
1. Viscosity Giredhi
Viscosity ndiyo parameter yakakosha inotsanangura giredhi reHPMC. Zvinoreva kukora kana kuramba kuyerera kweHPMC mhinduro. HPMC ine viscosity kubva pasi kusvika kumusoro uye inowanzoyerwa mu centipoise (cP) kana yanyungudutswa mumvura. Mamwe akajairika viscosity mamakisi anosanganisira:
Low viscosity mamakisi (eg, 3 kusvika 50 cP): Magiredhi aya anoshandiswa mumaapplication anoda yakaderera viscosity mhinduro, senge muindasitiri yezvekudya sezvidziviriro, thickeners, kana emulsifiers.
Medium viscosity mamakisi (semuenzaniso, 100 kusvika 4000 cP): Medium viscosity HPMC inoshandiswa mukudzorwa kuburitswa kwemishonga uye sekusunga mukugadzirwa kwehwendefa.
High viscosity mamakisi (semuenzaniso, 10,000 kusvika 100,000 cP): High viscosity mamakisi anowanzo shandiswa mukuvaka, kunyanya simende-based madhaka, adhesives, uye plasters, uko anovandudza kushanda, kuchengetedza mvura, uye kunamatira.
2. Dhigirii reKutsiva (DS) uye Molar Kutsiva (MS)
Chiyero chekutsiva chinoreva huwandu hwehuwandu hwemapoka ehydroxyl pane cellulose molecule inotsiviwa nemethoxy (-OCH3) kana hydroxypropyl (-OCH2CHOHCH3) mapoka. Iyo dhigirii yekutsiva inokanganisa kunyungudika, tembiricha yegelation, uye viscosity yeHPMC. HPMC mamakisi akaiswa muzvikamu zvichibva pane methoxy uye hydroxypropyl zvemukati:
Methoxy yemukati (28-30%): Yepamusoro methoxy yemukati kazhinji inokonzeresa yakadzika tembiricha yegelation uye yakakwirira viscosity.
Hydroxypropyl yemukati (7-12%): Kuwedzera iyo hydroxypropyl yemukati kazhinji inovandudza kunyungudika mumvura inotonhora uye kunowedzera kushanduka.
3. Particle size distribution
Iyo particle size yeHPMC poda inogona kusiyanisa zvakanyanya, inokanganisa kuparara kwavo uye mashandiro mune imwe application. Iyo yakatsetseka iyo zvidimbu, inokurumidza kunyungudika, zvichiita kuti zvive zvakanyanya kukodzera kune zvikumbiro zvinoda kukurumidza hydration, senge indasitiri yechikafu. Mukuvaka, zvakanakisa kushandisa akaomesesa mamakisi ekuparadzira zvirinani mumasanganiswa akaoma.
4. Yakananga application mamakisi
HPMC inowanikwa mumagiredhi akasiyana-siyana, anoenderana nezvinodiwa zvemaindasitiri:
Pharmaceutical giredhi: Inoshandiswa sebhainda, firimu rekare, uye inodzorwa kuburitsa mumiriri mune yemuromo yakasimba dosage mafomu. Iyo inosangana yakasimba yekuchena zviyero uye kazhinji ine chaiyo viscosity uye inotsiva zvivakwa.
Giredhi rekuvaka: Iri giredhi reHPMC rakagadziridzwa kuti rishandiswe mune simende uye gypsum-based zvigadzirwa. Inovandudza kuchengetwa kwemvura, kushanda, uye kunamatira mumapurasita, madhaka, uye zvinonamira mataira. High viscosity mamakisi anowanzo kushandiswa munzvimbo ino.
Chikafu giredhi: Chikafu giredhi HPMC inotenderwa kushandiswa sechikafu chekuwedzera (E464) uye inogona kushandiswa seyakakora, emulsifier, uye stabilizer mune zvakasiyana zvigadzirwa, zvinosanganisira zvakabikwa uye mukaka zvinotsiva. Inofanirwa kuenderana nemirairo yekuchengetedza chikafu uye kazhinji yakaderera mukusachena.
Cosmetic giredhi: Muzvigadzirwa zvekuchengetedza munhu, HPMC inoshandiswa seyakakora, emulsifier, uye firimu rekare. Inopa maitiro akatsetseka kune makirimu, lotions, uye shampoos.
5. Akagadziridzwa mamakisi
Mamwe maapplication anoda akagadziridzwa HPMC mamakisi, uko iyo polymer inogadziriswa makemikari kuti iwedzere chaiyo zvivakwa:
Muchinjikwa-yakabatana HPMC: Iyi gadziriso inovandudza gel simba uye kugadzikana mune inodzorwa-kuburitsa maumbirwo.
Hydrophobic modified HPMC: Rudzi urwu rweHPMC runoshandiswa mukugadzirwa kunoda kusimbaradzwa kwemvura, semapendi nependi.
6. Gel tembiricha mamakisi
Iyo tembiricha yegel yeHPMC ndiyo tembiricha iyo mhinduro inotanga kuumba gel. Izvo zvinoenderana nehuwandu hwekutsiva uye viscosity. Magiredhi akasiyana anowanikwa zvichienderana neinoda tembiricha yegel:
Yakaderera gel tembiricha mamakisi: Aya mamakisi gel pane yakaderera tembiricha, ichiita kuti ive yakakodzera kune inopisa mamiriro ekunze kana chaiwo maindasitiri maitiro anoda yakadzika tembiricha.
Yakakwira gel tembiricha mamakisi: Aya anoshandiswa mumashandisirwo anoda kuumbwa kwegel pane tembiricha yepamusoro, senge mamwe magadzirirwo emishonga.
HPMC inowanikwa mumhando dzakasiyana siyana kuti isangane nezvinodiwa chaizvo zvemaindasitiri akasiyana. Sarudzo yegiredhi reHPMC inotsamira pane inodiwa viscosity, dhigirii rekutsiva, particle size, uye chaiyo application zvinodiwa. Ingave ichishandiswa mumishonga, kuvaka, chikafu kana zvizorwa, iyo chaiyo giredhi yeHPMC yakakosha kuti uwane inodiwa zvivakwa uye kushanda mune yekupedzisira chigadzirwa.
Nguva yekutumira: Aug-27-2024