(1). Nhanganyaya
Hydroxypropyl methylcellulose (HPMC), inozivikanwawo se hydroxypropyl methylcellulose, inogoneka semi-synthetic cellulose ether ine zvakasiyana siyana zvekushandisa kwemishonga. Kushandiswa kweHPMC mumunda wemishonga kunonyanya kukonzerwa nekunaka kwayo kwemuviri uye makemikari zvimiro, kusanganisira firimu-kugadzira, gelling, thickening, adhesion uye kugadzikana. Sechinhu chine inert uye chisiri-ionic, HPMC inogona kunyatso kupa yadzorwa kuburitswa, kuravira masking, firimu-kuumba, adhesion uye kudzivirira mabasa mumishonga kugadzirira.
(2). Kuumbwa uye kugadzirira
HPMC inogadziriswa nepartial methylation uye hydroxypropylation ye cellulose ne etherification ye cellulose ine methanol uye propylene oxide pasi pemamiriro ealkaline. Izvo zvimiro zveHPMC, senge viscosity, gelation tembiricha uye solubility, zvinokanganiswa neinotsiva yemukati uye molecular uremu. Kugadzirwa kwegiredhi remishonga HPMC kunofanirwa kusangana nemhando dzakasimba zviyero kuti ive nechokwadi chekuchena kwayo uye kuenderana kuzadzisa zvinodiwa zvekugadzirira kwemishonga.
(3). Zvenyama uye zvemakemikari zvinhu
Firimu-yekugadzira chivakwa: HPMC inogona kuumba yakajeka, isina ruvara, inochinjika firimu.
Kunyungudika kwemvura: Inonyungudika nekukurumidza mumvura inotonhora, asi inoumba gel mumvura inopisa.
Viscosity control: Iyo viscosity yeHPMC mhinduro inogona kudzorwa nekugadzirisa iko kusungirirwa kwayo uye huremu hwemamorekuru.
Kemikari inertness: Yakagadzikana mumakemikari pasi pemamiriro mazhinji uye haiite nemishonga yemishonga.
(4). Pharmaceutical applications
4.1 Kudzorwa kuburitswa gadziriro
HPMC inoita basa rakakosha mukuchengetedza-kuburitswa uye kudzorwa-kuburitswa gadziriro. Inogona kugadzira chipingamupinyi chejeri, kudzora mwero wekunyungudika kwemushonga, uye kuzadzisa chinangwa chekuwedzera nguva yekuita kwemushonga.
Oral controlled-release tablets: Nekusanganisa nemushonga, inoumba matrix yekunonoka kuburitswa kwemushonga. Semubatsiri mukuru mune mamwe mapiritsi anoramba achiburitswa, HPMC inogona zvishoma nezvishoma hydrate uye kugadzira gel layer kudzora kuburitswa kwemushonga.
Microspheres uye microcapsules: Semugadziri wemufirimu-mugadziri kana kuturika stabilizer, inoshandiswa kuvharidzira zvimedu zvezvinodhaka uye kuderedza chiyero chekuburitsa.
4.2 Kupfekedza Zvishandiso
Sezvinhu zvekupfekedza, HPMC inogona kupa kudzivirira kwezvinodhaka, kudzora kuburitsa, kunatsiridza chitarisiko, uye mask inonhuhwirira isingafadzi kana kuravira.
Enteric coating: HPMC inosanganiswa nemamwe mapolymers kugadzira enteric coatings isingaite gastric muto, kuve nechokwadi chekuti mushonga unoburitswa muura kwete mudumbu.
Firimu yekuputira: Firimu yekuputira inoshandiswa mahwendefa kana granules kuvandudza kugadzikana uye kumedza kunyaradza.
4.3 Binders
Izvo zvinosunga zvimiro zveHPMC zvinoita kuti ive yakakodzera binder yekugadzirira piritsi. Inogona kuvandudza kusungirirwa kwehupfu uye simba remagetsi remapiritsi.
Mahwendefa: Anoshandiswa sebhainda mukunyorova granulation kuona kuti hupfu hunogona kudzvanywa kuita mahwendefa akasimba uye akafanana.
Granular kugadzirira: HPMC inogona kuvandudza kufanana uye kusimba kwemagranules uye kuderedza kuparara nguva.
4.4 Makobvu uye ekumisa maajenti
Semakobvu uye ekumisa maajenti, HPMC inogona kuvandudza kugadzikana uye kufanana kwegadziriro yemvura.
Zvinwiwa zvemumuromo: Kuvandudza kuravira uye kugadzikana uye kudzivirira kunaya kwezvinwiwa.
Topical application: Inoshandiswa seyakakora mumakirimu uye gels kupa yakakodzera viscosity uye kubata.
4.5 Ophthalmic Applications
HPMC inoshandiswa zvakanyanya mukugadzirira kwemaziso, kunyanya misodzi yekugadzira uye ophthalmic gels.
Misodzi yeArtificial: Semafuta ekuzora, inopa hunyoro hwekunyorova uye inobvisa zviratidzo zvemaziso akaoma.
Ophthalmic gel: Inowedzera nguva yekugara kwemushonga panzvimbo yemaziso uye inovandudza kushanda.
4.6 Capsules
HPMC inogona kushandiswa kugadzira miriwo capsules (HPMC capsules) sechinzvimbo chegelatin capsules, yakakodzera kune vanodya miriwo kana varwere vasingawirirani nemhuka-yakatorwa zvigadzirwa.
Vegetarian capsules: Ipa zvakafanana dissolution properties kune gelatin capsules uye hazvikanganisi nenyaya dzehutsika dzezvigadzirwa zvemhuka.
(5). Zvakanakira
Biocompatibility: HPMC haisi-chepfu uye isingatsamwisi, yakakodzera kune zvakasiyana-siyana zvekugadzirira zvinodhaka.
Kugadzikana kwekemikari: Haiite neinoshingaira mishonga yemishonga uye inochengetedza kushandiswa kwezvinodhaka.
Versatility: Inogona kushandiswa mukudzorwa kusunungurwa, kupeta, kubatana, kukora uye kumiswa.
Iine hushamwari kwezvakatipoteredza: HPMC inogadzirwa kubva kune yakasikwa cellulose uye inogona kudzokororwa uye biodegradable.
6. Matambudziko uye Zvinotarisirwa
Kunyangwe HPMC ine akawanda mabhenefiti mukugadzirira zvinodhaka, kune zvakare matambudziko mune dzimwe nguva. Semuyenzaniso, zvimiro zvayo zvemuviri zvingangoda kuvandudzwa kuti ive nechokwadi chekuburitswa kwemushonga wakafanana pakuremerwa kwezvinodhaka. Pamusoro pezvo, tsvakiridzo yeramangwana inogona kutarisisa kuenderera mberi nekuvandudza mashandisirwo eHPMC mune yepamusoro-inoshanda dhizaini masisitimu nekuchinja kwemamorekuru kana kusanganisa nezvimwe zvinopa kuti iwedzere kuita kwayo.
Pharmaceutical giredhi hydroxypropyl methylcellulose (HPMC) inoita basa risingadzokerike mukugadzirwa kwemazuva ano kwemishonga nekuda kwekusiyana-siyana kwayo uye yakanakisa physicochemical properties. Kubva pakuburitswa kunodzorwa, kupeta kusvika pakubatana uye kukora, huwandu hwekushandisa hweHPMC hwakakura uye huri kuwedzera. Nekufambira mberi kwehunyanzvi uye kugadzirwa kwemishonga mitsva, HPMC ichaita basa rakakosha mune ramangwana rekupa zvinodhaka masisitimu.
Nguva yekutumira: Jun-14-2024