Hydroxypropyl methylcellulose inonzi yakakurumbira mvura-soluble polymer inoumba mhinduro yakajeka uye yakagadzikana mumvura uye inoshandiswa zvakanyanya mumaindasitiri emishonga, ezvekudya uye ekuvaka. Iyo isiri-ionic cellulose-yakavakirwa mbishi zvinhu inovandudza kusungirirwa uye yakabatana zvinhu zvechigadzirwa chekupedzisira. Kuti uve nechokwadi chekuita kwemhando yepamusoro yehydroxypropyl methylcellulose, chigadzirwa chinoda kuongororwa uye kugona chisati chashandiswa. Muchikamu chino, tichakurukura nzira nhatu dzakavimbika dzekutaurira kunaka kwehydroxypropyl methylcellulose.
1. Viscosity test
Iyo viscosity yehydroxypropyl methylcellulose yakakosha parameter kuona kunaka kwayo. Viscosity ndiko kuramba kwemvura kuyerera uye inoyerwa necentipoise (cps) kana mPa.s. Iyo viscosity yehydroxypropyl methylcellulose inosiyana zvichienderana nehuremu hwayo hwemamorekuru uye dhigirii rekutsiva. Iyo yakakwirira yedhigirii yekutsiva, yakaderera iyo viscosity yechigadzirwa.
Kuti uedze viscosity yehydroxypropyl methylcellulose, nyungudutsa zvishoma zvechigadzirwa mumvura uye shandisa viscometer kuyera viscosity yemhinduro. Iyo viscosity yemushonga inofanirwa kunge iri mukati meiyo yakakurudzirwa huwandu hwakapihwa nemutengesi wechigadzirwa. Chigadzirwa chakanaka chehydroxypropyl methylcellulose chinofanira kunge chine viscosity inowirirana, iyo inoratidza kuchena uye yunifomu particle size.
2. Kutsiva bvunzo
Iyo dhigirii yekutsiva inoreva chiyero chehuwandu hwemapoka ehydroxyl pane cellulose inotsiviwa nehydroxypropyl kana methyl mapoka. Dhigirii rekutsinhanisa chiratidzo chekuchena kwechigadzirwa, iyo yakakwirira dhigirii yekutsiva, iyo yakachena chigadzirwa. Yepamusoro-mhando yehydroxypropyl methylcellulose zvigadzirwa zvinofanirwa kuve nehupamhi hwekutsiva.
Kuti uedze dhigirii rekutsiva, titration inoitwa ne sodium hydroxide uye hydrochloric acid. Sarudza huwandu hwesodium hydroxide inodiwa kumisa hydroxypropyl methylcellulose uye kuverenga dhigirii yekutsiva uchishandisa inotevera formula:
Degree of Substitution = ([Volume of NaOH] x [Molarity of NaOH] x 162) / ([Huremu hweHydroxypropyl Methyl Cellulose] x 3)
Chiyero chekutsiva chinofanira kunge chiri mukati mechikamu chinokurudzirwa chinopihwa nemutengesi wechigadzirwa. Iyo dhigirii yekutsiviwa yemhando yepamusoro hydroxypropyl methylcellulose zvigadzirwa zvinofanirwa kunge zviri mukati meiyo inokurudzirwa renji.
3. Solubility test
Iyo solubility ye hydroxypropyl methylcellulose ndiyo imwe yakakosha parameter inotaridza kunaka kwayo. Chigadzirwa chacho chinofanira kuve nyore kunyungudika mumvura uye kwete kugadzira mapundu kana gel. Yepamusoro-mhando hydroxypropyl methylcellulose zvigadzirwa zvinofanirwa kunyungudika nekukurumidza uye zvakaenzana.
Kuti uite bvunzo yekunyungudika, bvisa chidimbu chidiki chechigadzirwa mumvura uye simbisa mhinduro yacho kusvika yanyungudika zvachose. Mushonga wacho unofanirwa kuva wakajeka uye usina mazamu kana gel. Kana chigadzirwa chikasanyungudika zviri nyore kana kuita mapundu kana gels, chinogona kunge chiri chiratidzo chehurombo.
Mukupedzisa, hydroxypropyl methylcellulose chinhu chakakosha mbishi chinoshandiswa mumaindasitiri akasiyana. Kuti uve nechokwadi chemhando yepamusoro yechigadzirwa, viscosity, kutsiva uye solubility bvunzo dzinoitwa. Iyi miedzo ichabatsira kunzwisisa zvakajeka maitiro echigadzirwa uye kubatsira kusiyanisa kunaka kwayo. Yepamusoro-mhando hydroxypropyl methylcellulose ine viscosity inowirirana, yakakwirira dhigirii yekutsiva, uye inonyungudika nekukurumidza uye zvakafanana mumvura.
Nguva yekutumira: Jul-11-2023