Abstract:
Hydroxypropyl Methylcellulose (HPMC) ipolymer inoshandiswa zvakanyanya mumishonga, zvigadzirwa zvekudya, zvekuzora, uye akasiyana maindasitiri ekushandisa nekuda kweakasiyana zvimiro senge firimu-kugadzira kugona, kukora zvivakwa, uye inodzorwa kuburitsa maitiro. Nekudaro, kunzwisisa kugadzikana kwayo kwekupisa uye hunhu hwekudzikisira munzvimbo dzakasiyana kwakakosha pakuve nechokwadi chemhando yechigadzirwa uye kuita.
Nhanganyaya:
HPMC ndeye semi-synthetic polymer inotorwa kubva muselulosi uye yakagadziridzwa kuburikidza nekuwedzera kwehydroxypropyl uye methyl mapoka. Kushandiswa kwayo kwakapararira mumaindasitiri akasiyana-siyana kunoda kunzwisisa kwakadzama kwekugadzikana kwayo pasi pemamiriro akasiyana. Kudzikama (Thermal Stability) zvinoreva kugona kwechinhu kuramba kudzikira kana kuora kana chapiswa. Kuparara kweHPMC kunogona kuitika nenzira dzakasiyana-siyana, kusanganisira hydrolysis, oxidation, uye kuora kwekupisa, zvichienderana nemamiriro ekunze.
Thermal Kugadzikana kweHPMC:
Kugadzikana kwekupisa kweHPMC kunokonzerwa nezvinhu zvakati wandei, zvinosanganisira huremu hwemamorekuru, dhigirii rekutsiva, uye kuvapo kwetsvina. Kazhinji, HPMC inoratidza kugadzikana kwakanaka kwekupisa, nekuora kwekushisa kunowanzo kubva pa200 ° C kusvika 300 ° C. Nekudaro, izvi zvinogona kusiyana zvichienderana negiredhi chairo uye kuumbwa kweHPMC.
Mhedzisiro yeTembiricha:
Kukwirisa tembiricha kunogona kukurumidza kushatisa kweHPMC, zvichikonzera kudzikira kwehuremu hwemamorekuru, viscosity, uye firimu-kugadzira zvinhu. Pamusoro pechimwe chikumbaridzo chetembiricha, kuora kwekupisa kunova kwakakosha, zvichikonzera kuburitswa kwezvinhu zvinoshanduka zvakaita semvura, carbon dioxide, uye madiki organic compounds.
Migumisiro Yehunyoro:
Humidity inogona zvakare kukanganisa kugadzikana kwekupisa kweHPMC, kunyanya munzvimbo dzakakwirira dzehunyoro. Mamorekuru emvura anogona kufambisa kuderedzwa kwehydrolytic yeHPMC maketani, zvichitungamira kune cheni scission uye kudzikisira mukutendeseka kwepolymer. Pamusoro pezvo, kutora hunyoro kunogona kukanganisa zvimiro zveHPMC-zvakavakirwa zvigadzirwa, senge kuzvimba maitiro uye dissolution kinetics.
Mhedzisiro ye pH:
Iyo pH yezvakatipoteredza inogona kukanganisa kushatisa kinetics yeHPMC, kunyanya mune aqueous mhinduro. Yakanyanya pH mamiriro (acidic kana alkaline) inogona kukurumidza kuita hydrolysis, zvichitungamira kukurumidza kuderedzwa kwemaketani epolymer. Naizvozvo, iyo pH kugadzikana kweHPMC maumbirwo anofanira kunyatsoongororwa kuti ive nechokwadi chekushanda kwechigadzirwa uye pasherufu-hupenyu.
Kudyidzana Nezvimwe Zvinhu:
HPMC inogona kudyidzana nezvimwe zvinhu zviripo munzvimbo yayo, senge zvinodhaka, excipients, uye zvekurongedza zvinhu. Kudyidzana uku kunogona kukanganisa kugadzikana kwekupisa kweHPMC kuburikidza nenzira dzakasiyana siyana, kusanganisira catalysis yezvinokanganisa maitiro, kuumbwa kwezvakaoma, kana kushambadza kwemuviri panzvimbo.
Kunzwisisa kugadzikana kwekupisa uye kudzikisira maitiro eHPMC kwakakosha pakugadzirisa mashandiro ayo mumashandisirwo akasiyana siyana. Zvinhu zvakadai sekushisa, humidity, pH, uye kudyidzana nezvimwe zvinhu zvinogona kukanganisa kugadzikana kweHPMC-yakavakirwa zvigadzirwa. Nekunyatso kudzora ma parameter aya uye nekusarudza maumbirwo akakodzera, vagadziri vanogona kuve nechokwadi chemhando uye kushanda kweHPMC-ine maumbirwo munzvimbo dzakasiyana siyana. Imwe tsvagiridzo inodiwa kujekesa nzira dzekudzikisira uye kugadzira nzira dzekusimudzira kugadzikana kwekupisa kweHPMC.
Nguva yekutumira: Chivabvu-08-2024