HPMC (hydroxypropyl methylcellulose) inowanzoshandiswa mukugadzirwa kwemhando dzakasiyana dzemhando dzemishonga, kusanganisira mapiritsi, capsules, uye zvigadzirwa zvemaziso. Chimwe chezvinhu zvakakosha zveHPMC ndeye viscosity yayo, iyo inokanganisa maitiro echigadzirwa chekupedzisira. Ichi chinyorwa chichaongorora hukama huripo pakati peHPMC viscosity uye tembiricha uye inosimbisa dzimwe dziviriro dzinofanirwa kutorwa kana uchishandisa uyu excipient.
Hukama pakati peHPMC viscosity uye tembiricha
HPMC inonzi hydrophilic polymer inonyungudika mumvura uye zvimwe zvinonyungudutsa polar. Kana HPMC yanyungudutswa mumvura, inoumba viscous solution nekuda kwehuremu hwepolymer yakakura uye dhigirii repamusoro rehydrophilicity. Iyo viscosity yeHPMC mhinduro inobatwa nezvinhu zvakati wandei, kusanganisira kuwanda kwepolymer, tembiricha yemushonga, uye pH yezvinonyungudutsa.
Chimwe chezvinhu zvakakosha zvinokanganisa viscosity yeHPMC mhinduro tembiricha. Iyo viscosity yeHPMC mhinduro inodzikira nekuwedzera tembiricha. Izvi zvinodaro nekuti pakupisa kwepamusoro, cheni dzepolymer dzinowedzera kuyerera, zvichikonzera mashoma emagetsi epakati akabata cheni dzepolymer pamwechete. Somugumisiro, viscosity yemhinduro inoderera uye fluidity yemhinduro inowedzera.
Hukama huri pakati petembiricha neHPMC viscosity hunogona kutsanangurwa neArrhenius equation. Arrhenius equation ienzaniso yemasvomhu inotsanangura hukama huripo pakati pechiyero chekuita kwekemikari nekupisa kwehurongwa. Kune HPMC mhinduro, iyo Arrhenius equation inogona kushandiswa kutsanangura hukama pakati pemhinduro viscosity uye tembiricha yehurongwa.
Iyo Arrhenius equation inopiwa ne:
k = Ae^(-Ea/RT)
uko k ndiyo chiyero chinogara chiripo, A ndiyo pre-exponential factor, Ea ndiyo activation simba, R ndiyo gasi risingaperi, uye T ndiyo tembiricha yehurongwa. Iyo viscosity yeHPMC mhinduro ine hukama nekuyerera kweyero yekunyungudutsa kuburikidza nepolymer matrix, iyo inodzorwa neiyo imwechete musimboti seyero yekuchinja kwemakemikari. Naizvozvo, iyo Arrhenius equation inogona kushandiswa kutsanangura hukama pakati pemhinduro viscosity uye tembiricha yehurongwa.
Zvinhu zvekucherechedza kana uchishandisa HPMC
Paunenge uchishanda neHPMC, matanho akati wandei anofanirwa kutorwa kuve nechokwadi chekubata kwakachengeteka uye kwakanaka kwepolymer. Aya ekudzivirira anosanganisira:
1. Shandisa midziyo yekudzivirira
Zvakakosha kushandisa midziyo yekudzivirira yakaita semagirovhosi, magirovhosi, uye majasi erabhoritari paunenge uchibata HPMC. Izvi zvinodaro nekuti HPMC inogona kutsamwisa ganda nemaziso, uye inogona kukonzera matambudziko ekufema kana ikafemerwa. Naizvozvo, zvakakosha kutora matanho ekudzikisa njodzi yekusangana nemapolymers.
2. Sevha HPMC nemazvo
HPMC inofanira kuchengetwa munzvimbo inotonhorera, yakaoma kudzivirira kutorwa kwemwando mumhepo. Izvi zvinodaro nekuti HPMC ndeye hygroscopic, zvichireva kuti inotora hunyoro kubva kune yakatenderedza nharaunda. Kana HPMC ikatora hunyoro hwakawandisa, inogona kukanganisa viscosity uye zvimiro zvechigadzirwa chekupedzisira.
3. Nyatsoteerera kuisa pfungwa uye tembiricha
Paunenge uchigadzira neHPMC, iva nechokwadi chekuteerera kune kusungwa uye tembiricha yemhinduro. Izvi zvinodaro nekuti viscosity yeHPMC mhinduro inonyanya kutsanangurwa nezvinhu izvi. Kana iyo yekumisikidza kana tembiricha yakakwira zvakanyanya kana yakaderera, inokanganisa viscosity uye zvimiro zvechigadzirwa chekupedzisira.
4. Shandisa nzira dzakakodzera dzekugadzirisa
Kana uchigadzira HPMC, zvakakosha kushandisa nzira dzakakodzera dzekugadzirisa kuti uve nechokwadi chekubata kwakachengeteka uye kwakanaka kwepolymer. Izvi zvinogona kusanganisira kushandisa nzira dzakaderera-kuveura kusanganisa kudzivirira kuveura kwepolymer kana kuputsika, kana kushandisa nzira dzakakodzera dzekuomesa kubvisa mwando wakawandisa kubva pachigadzirwa chekupedzisira.
5. Tarisa kuenderana
Paunenge uchishandisa HPMC sechinhu chinobatsira, zvakakosha kuti utarise kuenderana nemamwe maexcipients uye mashandiro anoshanda mukuumbwa. Izvi zvinodaro nekuti HPMC inogona kudyidzana nezvimwe zvinongedzo mukugadzira, zvichikanganisa kuita uye kugadzikana kwechigadzirwa chekupedzisira. Naizvozvo, zvakakosha kuita zvidzidzo zvekuenderana kuti uone chero zvingangoitika usati waenderera mberi nekugadzira.
mukupedzisa
Iyo viscosity yeHPMC mhinduro inokanganiswa nezvakati wandei zvinhu, zvinosanganisira kusungwa, tembiricha, uye pH. Iyo viscosity yeHPMC mhinduro inodzikira nekuwedzera tembiricha nekuda kwekuwedzera kwekufamba kwemaketani epolymer. Paunenge uchishanda neHPMC, zvakakosha kutora matanho akakodzera kuti uve nechokwadi chekubata kwakachengeteka uye kwakanaka kwepolymer. Aya ekuchenjerera anosanganisira kushandisa michina yekudzivirira, kuchengetedza nemazvo HPMC, kutarisisa kutarisisa uye tembiricha, uchishandisa nzira dzakakodzera dzekugadzirisa, uye kutarisa kuenderana nezvimwe zvinongedzo mufomula. Nekutora idzi chenjedzo, HPMC inogona kushandiswa seyakasiyana-siyana yemishonga mafomu.
Nguva yekutumira: Sep-25-2023