HPMC ndeye semi-synthetic polymer inotorwa kubva ku cellulose. Nekuda kwekunaka kwayo kukora, kudzikamisa uye kugadzira mafirimu, inoshandiswa zvakanyanya mumishonga, chikafu, zvizorwa uye mamwe maindasitiri. Kudzidza maitiro ayo eviscosity kwakakosha kukwirisa kuita kwayo mumashandisirwo akasiyana.
1. Viscosity kuyerwa:
Rotational Viscometer: Iyo inotenderera viscometer inoyera torque inodiwa kutenderedza spindle painomhanya isingaperi kana yakanyudzwa mumuenzaniso. Nekusiyanisa iyo geometry uye kutenderera kumhanya kweiyo spindle, iyo viscosity pane akasiyana shear mitengo inogona kutsanangurwa. Iyi nzira inogonesa maitiro eHPMC viscosity pasi pemamiriro akasiyana.
Capillary Viscometer: A capillary viscometer inoyera kuyerera kwemvura kuburikidza necapillary chubhu pasi pesimba regiravhiti kana kudzvanywa. Iyo HPMC mhinduro inomanikidzwa kuburikidza necapillary chubhu uye viscosity inoverengerwa zvichienderana neyekuyerera uye kudonha kwekumanikidza. Iyi nzira inogona kushandiswa kudzidza HPMC viscosity pakaderera shear mitengo.
2.Rheological kuyerwa:
Dynamic Shear Rheometry (DSR): DSR inoyera mhinduro yechinhu kune inoshanduka shear deformation. HPMC samples dzakaiswa pasi pe oscillatory shear stress uye mhedzisiro inokonzeresa yakayerwa. Iyo viscoelastic maitiro eHPMC mhinduro anogona kuratidzwa nekuongorora iyo yakaoma viscosity (η*) pamwe neyekuchengetera modulus (G') uye kurasikirwa modulus (G”).
Miedzo yeCreep uye yekudzoreredza: Iyi miedzo inosanganisira kuisa HPMC masampuli kuti arambe achishushikana kana kunetseka kwenguva yakareba (iyo inokambaira chikamu) uyezve kuongorora kunotevera kupora mushure mekushushikana kana kuomerwa kwadzikiswa. Kukambaira uye kudzoreredza maitiro anopa nzwisiso mune viscoelastic zvivakwa zveHPMC, kusanganisira kushanduka kwayo uye kugona kudzoreredza.
3. Concentration uye tembiricha kutsamira zvidzidzo:
Concentration Scan: Viscosity kuyerwa kunoitwa pamusoro pehuwandu hweHPMC kutarisisa kudzidza hukama pakati pe viscosity uye polymer concentration. Izvi zvinobatsira kunzwisisa iko kukora kwepolymer uye hunhu hwayo hunotsamira.
Temperature scan: Viscosity kuyerwa kunoitwa patembiricha dzakasiyana kuti udzidze maitiro ekushisa paHPMC viscosity. Kunzwisisa kutsamira kwetembiricha kwakakosha pakushandisa uko HPMCs inosangana nekuchinja kwetembiricha, senge maumbirwo emishonga.
4. Kuongororwa uremu hweMolecular:
Size Kusabatanidzwa Chromatography (SEC): SEC inopatsanura mapolymer mamorekuru zvichienderana nehukuru hwavo mumhinduro. Nekuongorora iyo elution mbiri, iyo molecular huremu kugoverwa kweHPMC sampu inogona kutariswa. Kunzwisisa hukama pakati pehuremu hwemamorekuru uye viscosity kwakakosha kufanotaura maitiro erheological eHPMC.
5. Modelling uye Simulation:
Theoretical modhi: Yakasiyana-siyana yedzidziso modhi, senge Carreau-Yasuda modhi, Muchinjikwa modhi kana simba mutemo modhi, inogona kushandiswa kurondedzera viscosity maitiro eHPMC pasi pemamiriro akasiyana ekugera. Aya mamodheru anosanganisa ma parameter akadai seshear rate, concentration, uye molecular uremu kunyatsofanotaura viscosity.
Computational Simulations: Computational Fluid Dynamics (CFD) simulations inopa nzwisiso mukuyerera maitiro eHPMC mhinduro mune yakaoma geometries. Nekugadzirisa nenhamba maequation anotonga ekuyerera kwemvura, CFD simulations inogona kufanotaura kugovera viscosity uye kuyerera maitiro pasi pemamiriro akasiyana.
6. In situ uye in vitro zvidzidzo:
In-situ zviyero: In-situ matekiniki anosanganisira kudzidza chaiyo-nguva viscosity shanduko mune yakatarwa nharaunda kana application. Semuenzaniso, mukugadzirwa kwemishonga, in situ zviyero zvinogona kutarisa shanduko ye viscosity panguva yekuparara kwehwendefa kana topical gel kushandiswa.
In vitro kuyedzwa: In vitro bvunzo inotevedzera mamiriro emuviri kuti aongorore viscosity maitiro eHPMC-yakavakirwa maumbirwo akagadzirirwa nemuromo, ocular, kana topical management. Miedzo iyi inopa ruzivo rwakakosha nezvekuita uye kugadzikana kwechigadzirwa pasi pemamiriro akakodzera ebhayoloji.
7.Tekinoroji yepamusoro:
Microrheology: Microrheology maitiro, akadai se dynamic light scattering (DLS) kana particle tracking microrheology (PTM), inobvumira kuongorora viscoelastic zvimiro zvemvura yakaoma pachiyero chidiki. Aya matekiniki anogona kupa nzwisiso mune maitiro eHPMC padanho remamorekuru, achizadzisa macroscopic rheological zviyero.
Nuclear Magnetic Resonance (NMR) Spectroscopy: NMR spectroscopy inogona kushandiswa kudzidza mamorekuru masimba uye kudyidzana kweHPMC mumhinduro. Nekutarisa kushanduka kwemakemikari uye nguva dzekuzorora, NMR inopa ruzivo rwakakosha pane HPMC conformational shanduko uye polymer-solvent kupindirana kunokanganisa viscosity.
Kudzidza maitiro e viscosity yeHPMC kunoda nzira yemhando dzakasiyana-siyana, kusanganisira hunyanzvi hwekuyedza, dzidziso yekuenzanisira, uye nzira dzekuongorora dzepamusoro. Nekushandisa musanganiswa we viscometry, rheometry, kuongorora mamorekuru, kuenzanisira, uye matekiniki epamusoro, vaongorori vanogona kuwana kunzwisisa kuzere kweiyo rheological zvimiro zveHPMC uye nekugonesa kuita kwayo mumhando dzakasiyana dzekushandisa.
Nguva yekutumira: Feb-29-2024