Pharmaceutical Giredhi Hydroxypropyl Methylcellulose (HPMC) inowanzoshandiswa mishonga excipient, inoshandiswa zvakanyanya muindasitiri yemishonga. Iyo inonzi semi-synthetic, inert, mvura-soluble cellulose ether, iyo inogadziriswa kemikari kubva kune yakasikwa cellulose. HPMC ine yakanaka firimu-kuumba, thickening, adhesion, kuturika uye anti-caking zvimiro, saka ine yakakosha application kukosha mukugadzirira kwemishonga.
1. Zvinhu zvakakosha zveHPMC
HPMC inogadzirwa nekutsiva iyo hydroxyl chikamu che cellulose ne hydroxypropyl uye methoxy mapoka. Chimiro chayo chemorekuru chine maviri anotsiva, hydroxypropyl uye methyl, saka inonzi hydroxypropyl methylcellulose. HPMC ine solubility yakanaka mumvura, uye mushure mekunyungudika, inoumba yakajeka viscous mhinduro. Sezvo kuwedzera kunowedzera, viscosity inowedzerawo. Mukuwedzera, HPMC ine kugadzikana kwakanaka kwekupisa uye kugadzikana kwemakemikari, uye ine kushivirira kwakanaka kune acid, alkali uye munyu mhinduro.
2. Kushandiswa kweHPMC mumishonga
HPMC inoshandiswa zvakanyanya muindasitiri yemishonga, kunyanya mune zvinotevera zvinhu:
a. Tablet coating
HPMC, sechinhu chekuputira mahwendefa, inogona kunyatsovhara kuravira kwakashata kwemishonga, kuvandudza kutaridzika kwemishonga, uye ine hunyoro-uchapupu uye anti-oxidation mhedzisiro. Mukuwedzera, inogona kurebesa nguva yekusunungurwa kwemishonga mudumbu remukati, nekudaro kuwana mhedzisiro kana inodzorwa yekuburitsa mhedzisiro.
b. Thickeners uye binders
Paunenge uchigadzira kumiswa, emulsions, capsules uye mamwe magadzirirwo, HPMC, seyakakora uye binder, inogona kuvandudza kugadzikana uye kufanana kwegadziriro. Panguva imwecheteyo, HPMC inogona zvakare kuwedzera kuoma uye kusimba kwemagetsi emapiritsi kuti ive nechokwadi chekuti mishonga yacho haisi nyore kutyoka panguva yekugadzira nekufambisa.
c. Kudzorwa uye kuenderera-kusunungurwa gadziriro
HPMC inowanzoshandiswa mukugadzirisa-kusunungurwa uye kusunungurwa-kusunungurwa kwekugadzirira nokuti gel layer yainoumba inogona kudzivirira mvura kuti ipinde muhwendefa, kuitira kuti kupera uye kusunungurwa kwechirwere zvinyatsogadziriswa. Nekugadzirisa viscosity uye dosage yeHPMC, chiyero chekuburitswa kwemushonga chinogona kudzorwa nemazvo, nguva yekuita zvemushonga inogona kurebeswa, uye kuwanda kwemushonga kunogona kuderedzwa.
d. Sokuzadza
Mukugadzirira kwe capsule, HPMC inogona kushandiswa senge yekuzadza kuzadza makapuleti. Kuenzaniswa neyakajairwa gelatin capsules, HPMC capsules ine zvakanakira kuve chirimwa-yakatorwa uye isina yemhuka zvinongedzo, saka akakodzera kune vanodya miriwo uye varwere vane taboo dzechitendero.
3. Kuchengetedzwa kweHPMC
Semubatsiri wemishonga, HPMC ine yakanaka biocompatibility uye chengetedzo. Haina kusvibiswa nema enzymes ekugaya mumuviri wemunhu uye inonyanya kubudiswa kubva mumuviri kuburikidza nematumbo, saka haitore chikamu mukugadzirisa mishonga yemasabolism uye haibudisi migumisiro ine chepfu. HPMC yakashandiswa zvakanyanya mumhando dzakasiyana dzemuromo, dzemusoro uye dzemajekiseni uye inozivikanwa neve pharmacopoeias pasi rese.
4. Musika tarisiro
Nekuenderera mberi kwekuvandudzwa kweindasitiri yemishonga, zvinodiwa zvemhando yezvinodhaka uye kuchengetedzwa zviri kuwedzera zvakare. Nekuda kwekusiyana kwayo kwemuviri uye makemikari zvimiro uye kuchengetedzwa kwakanaka, HPMC ine tarisiro yakakura yekushandisa mukugadzirira kwemishonga mitsva. Kunyanya muminda yekudzorwa-kuburitswa uye kuenderera-kuburitswa gadziriro, biological mishonga uye mishonga kune yakasarudzika vanhu (sevanodya miriwo), kudiwa kweHPMC kucharamba kuchikura.
Semubatsiri wemishonga yakawanda, giredhi remishonga hydroxypropyl methylcellulose yakaita basa rakakosha muindasitiri yemishonga uye icharamba ichishandiswa zvakanyanya uye kuvandudzwa mune ramangwana.
Nguva yekutumira: Aug-06-2024