Hydroxypropylmethylcellulose (HPMC) ikamu rinoshandiswa zvakasiyana-siyana rinoshandiswa mumaindasitiri akasiyana siyana anosanganisira emishonga, chikafu, kuvaka uye zvekuzora. Kunzwisisa kuumbwa kwayo, chimiro, zvivakwa uye mashandisirwo kunoda zvakadzama kudzidza kwemakemikari ayo uye synthesis process.
kuumbwa uye chimiro
Cellulose Backbone: HPMC inotorwa kubva ku cellulose, yakasikwa polymer inowanikwa mumiti sero madziro. Cellulose inoumbwa nemaketani marefu eglucose mayuniti akabatanidzwa pamwechete ne β-1,4 glycosidic bonds.
Methylation: Methylcellulose inotangira HPMC uye inogadzirwa nekurapa cellulose nealkali uye methyl chloride. Maitiro acho anosanganisira kutsiva hydroxyl (-OH) mapoka pane cellulose musana ne methyl (-CH3) mapoka.
Hydroxypropylation: Mushure memethylation, hydroxypropylation inoitika. Munhanho iyi, propylene oxide inopindirana nemethylated cellulose, ichiunza hydroxypropyl (-OCH2CHOHCH3) mapoka pamusana we cellulose.
Dhigirii reKutsiva (DS): Iyo dhigirii yekutsiva inoreva avhareji yenhamba yehydroxypropyl uye methyl mapoka paglucose unit mucheni ye cellulose. Iyi parameter inokanganisa zvimiro zveHPMC, kusanganisira kunyungudika kwayo, viscosity, uye maitiro ekupisa.
synthesis
Alkaline kurapwa: Cellulose fibers inotanga kurapwa nealkaline solution, kazhinji sodium hydroxide (NaOH), kuputsa intermolecular hydrogen bond uye kuwedzera kuwanikwa kwemapoka e-cellulose hydroxyl.
Methylation: Cellulose inobatwa nealkali inobatwa nemethyl chloride (CH3Cl) pasi pemamiriro ekudzora, zvichikonzera kutsiviwa kwemapoka ehydroxyl nemapoka emethyl.
Hydroxypropylation: Methylated cellulose inowedzera kuita nepropylene oxide (C3H6O) muhupo hwechinhu chinokonzeresa sesodium hydroxide. Izvi zvinounza mapoka ehydroxypropyl mumusana we cellulose.
Neutralization uye Kucheneswa: Neutralize musanganiswa wekuita kuti ubvise chero hwaro hwakawandisa. Chigadzirwa chakawanikwa chinoitwa nhanho dzekucheneswa senge kusefa, kugeza, uye kuomesa kuti uwane yekupedzisira HPMC chigadzirwa.
hunhu
Solubility: HPMC inonyungudika mumvura uye inoumba yakajeka, viscous mhinduro. Solubility inoenderana nezvinhu zvakaita sedhigirii rekutsiva, huremu hwemamorekuru, uye tembiricha.
Viscosity: HPMC mhinduro dzinoratidza pseudoplastic maitiro, zvichireva kuti viscosity yavo inodzikira nekuwedzera shear rate. Viscosity inogona kudzorwa nekugadzirisa ma parameter akadai seDS, molecular uremu uye kutarisisa.
Firimu Magadzirirwo: HPMC inoumba anochinjika uye akajeka mafirimu kana akakandwa kubva kune ayo aqueous mhinduro. Aya mafirimu anowana maapplication mumajasi, kurongedza uye nemishonga.
Thermal Kugadzikana: HPMC inogadzika nekushisa pane imwe tembiricha, pamusoro apo kushatisa kunoitika. Kugadzikana kwemafuta kunoenderana nezvinhu zvakaita seDS, hunyoro hwemukati, uye kuvapo kwezvinowedzera.
Nzvimbo dzekushandisa
Pharmaceuticals: HPMC inoshandiswa zvakanyanya mukugadzirwa kwemishonga semakobvu, mabhainda, ekugadzira firimu uye anoramba achiburitsa matrices. Inovandudza kuparara kwehwendefa, kupera uye bioavailability.
Chikafu: Muindasitiri yechikafu, HPMC inoshandiswa seyakakora, inodzikamisa, emulsifier uye yekuzadza mune zvigadzirwa zvakaita sesosi, mapfekero, zvakabikwa uye zvigadzirwa zvemukaka.
Kuvaka: HPMC inowedzerwa kune simende-based madhaka, stucco uye mataira anonamira kuvandudza kushanda, kuchengetedza mvura uye kunamatira. Inovandudza kushanda kwezvinhu izvi zvekuvaka mumamiriro ezvinhu akasiyana-siyana.
Cosmetics: HPMC inoshandiswa seyakakora, emulsifier uye stabilizer mukugadzira zvizorwa semafuta, lotions uye gels. Inopa inodiwa rheological properties uye inowedzera kugadzikana kwechigadzirwa.
Hydroxypropyl methylcellulose (HPMC) musanganiswa unoshanda wakagadzirwa kubva ku cellulose kuburikidza nemethylation uye hydroxypropylation maitiro. Chimiro chayo chemakemikari, zvivakwa uye mashandisirwo anoita kuti ive chinhu chakakosha mumaindasitiri akasiyana semishonga, chikafu, kuvaka uye zvizorwa. Kuwedzera kutsvagisa nekusimudzira tekinoroji yeHPMC inoenderera mberi nekuwedzera mashandisirwo ayo uye nekuvandudza mashandiro ayo mumhando dzakasiyana dzekugadzira.
Nguva yekutumira: Feb-20-2024