Hydroxypropylmethylcellulose (HPMC) i polymer inoshandiswa zvakasiyana-siyana inoshandiswa mumaindasitiri akasiyana siyana, anosanganisira mishonga, kuvaka, chikafu, uye zvekuzora. Imwe yeayo akajairika maapplication ari mukugadzira zvigadzirwa zvegel. Gels is semisolid systems ine yakasarudzika rheological properties, uye kushanda kwavo kunogona kukanganiswa nezvinhu zvakasiyana-siyana, kusanganisira tembiricha.
introduce
Hydroxypropylmethylcellulose (HPMC) is a cellulose derivative synthesized nekurapa cellulose nepropylene oxide uye methyl chloride. Iyo ndeyemhuri ye cellulose ether uye ine-inonyungudika nemvura uye gelling zvivakwa. HPMC inoshandiswa zvakanyanya mumaindasitiri emishonga, chikafu, kuvaka uye zvizorwa nekuda kwehunyanzvi hwayo hwekugadzira firimu, kukora uye gelling kugona.
Kuiswa kweHPMC
Gelation ndiyo nzira iyo mvura kana sol inoshandura kuita gel, semi-solid state iyo ine zvose mvura uye yakasimba. HPMC gels kuburikidza nemuchina we hydration uye matatu-dimensional network kuumbwa. Iyo gelation process inokanganiswa nezvinhu zvakaita se polymer concentration, molecular uremu uye tembiricha.
Kutsamira kwekushisa kwegelation
Tembiricha inoita basa rakakosha mukuita gelation kweHPMC. Hukama huri pakati petembiricha uye gelation hunogona kuve hwakaoma, uye zvakakosha kuti unzwisise kuti shanduko yekushisa inokanganisa sei zvinhu zveHPMC gels. Kazhinji kutaura, gelation yeHPMC ndeye exothermic process, zvichireva kuti inoburitsa kupisa.
1. Mhedziso yemafuta anopisa
Thermal gelation curves yeHPMC inoratidzirwa neiyo gelation tembiricha renji, kureva tembiricha siyana uko kunoitika shanduko kubva kusol kuenda kune gel. Iyo tembiricha yegelation inobatwa neiyo HPMC yekusungwa mune mhinduro. Kukwirira kwakanyanya kunowanzo konzera kukwira kwekushisa kwegelling.
2. Mhedzisiro pane viscosity
Tembiricha inokanganisa viscosity yeHPMC mhinduro uye nekudaro iyo gelation process. Sezvo tembiricha inowedzera, viscosity yeHPMC mhinduro inoderera. Iko kuderedzwa kwe viscosity kunokanganisa gel dynamics uye yekupedzisira gel properties. Tembiricha inofanira kunyatsodzorwa uye kutariswa panguva yekugadzira kuti uwane inodiwa viscosity uye gel zvivakwa.
Zvinhu zvinokanganisa tembiricha yegel
Zvinhu zvakati wandei zvinopesvedzera tembiricha yegel yeHPMC, uye kunzwisisa zvinhu izvi kwakakosha kune vanogadzira uye vanotsvaga.
1. Polymer concentration
Iko kusungirirwa kweHPMC mune fomula chinhu chakakosha chinokanganisa tembiricha yegelation. Kukwirira kwepamusoro kunowanzo konzera tembiricha yakakwira gelation. Hukama uhwu hunonzi hwakakonzerwa nehuwandu hwehuwandu hwepolymer cheni dziripo dzekudyidzana kweintermolecular, zvichikonzera kune yakasimba gel network.
2. Molecular uremu HPMC
Iyo molecular huremu hweHPMC inokanganisawo gelation. Yepamusoro mamorekuru huremu HPMC inogona kuratidza tembiricha yegel yakasiyana kana ichienzaniswa neyakadzika mamorekuru uremu HPMC. Kurema kwemamorekuru kunokanganisa kunyungudika kwepolymer, kusungirirwa kweketani, uye kusimba kweiyo gel network yakaumbwa.
3. Hydration rate
HPMC hydration rate inokanganiswa nekupisa. Kupisa kwepamusoro kunomhanyisa hydration process, zvichikonzera kukurumidza gelation. Izvi zvinonyanya kukosha kune nguva-sensitive formulations inoda kukurumidza gelation.
4. Kuvapo kwezvinowedzera
Kuvapo kwezvinowedzera zvakaita seplasticizers kana munyu zvinogona kushandura tembiricha yegelling yeHPMC. Izvi zvinowedzera zvinogona kudyidzana nemacheni epolymer, zvichikanganisa kugona kwavo kuumba gel network. Vagadziri vanofanirwa kunyatso funga nezve mhedzisiro yezvinowedzera pane gel maitiro.
Hunoshanda kukosha uye maapplication
Kunzwisisa tembiricha-inotsamira gel maitiro eHPMC kwakakosha pakugadzira zvigadzirwa zvine hunhu hunoenderana uye kuita. Kunzwisisa uku kunopa zvirevo zvakawanda zvinoshanda uye mashandisiro.
1. Kudzorwa kuburitsa zvinodhaka
Muindasitiri yemishonga, HPMC inowanzoshandiswa mukudzorwa-kuburitswa kwemishonga maumbirwo. Iyo tembiricha senitivity yeHPMC gels inogona kushandiswa kudzora kuburitswa kweanoshanda mishonga yemishonga. Nekunyatso gadzirisa tembiricha yegelation, vagadziri vanogona kugadzirisa maprofile ekuburitsa zvinodhaka.
2. Kupisa-kupindura hydrogels
Iyo tembiricha senitivity yeHPMC inoita kuti ive yakakodzera kuvandudza tembiricha inopindura mahydrogel. Aya ma hydrogels anogona kuchinjika sol-gel shanduko mukupindura shanduko yekushisa, ichiita kuti ive yakakosha kune maapplication akadai sekupora maronda uye kuendesa zvinodhaka.
3. Zvinhu zvekuvaka
Muindasitiri yekuvaka, HPMC inowanzo shandiswa sekuwedzera kune simende-yakavakirwa zvinhu kuvandudza kushanda uye kuchengetedza mvura. Iyo tembiricha senitivity yeHPMC inokanganisa kumisikidza nguva uye rheological zvimiro zvezvinhu izvi, nekudaro zvichikanganisa kuita kwavo panguva yekuvaka.
Matambudziko Nekugadzirisa
Nepo tembiricha-inotsamira gel maitiro eHPMC achipa akasiyana mabhenefiti, zvakare anoisa matambudziko mune mamwe maapplication. Semuyenzaniso, kuwana inopindirana gel zvivakwa zvinogona kunetsa mumigadziriso apo tembiricha kuchinja kwakajairika. Vagadziri vanofanira kufunga nezvematambudziko aya uye kushandisa nzira dzekuagadzirisa.
1. Kudzora kwekushisa panguva yekugadzirira
Kuve nechokwadi chekuitazve gel kuita, kwakasimba tembiricha kutonga panguva yekugadzira kwakakosha. Izvi zvinogona kusanganisira kushandisa tembiricha-inodzorwa kusanganisa michina uye kutarisa tembiricha mukati mekugadzira.
2. Kusarudzwa kwepolymer
Izvo zvakakosha kuti usarudze giredhi rakakodzera reHPMC neinodiwa tembiricha yegel maitiro. Akasiyana mamakisi eHPMC anowanikwa aine akasiyana mamorekuru uremu uye mazinga ekutsiva, achibvumira vanogadzira kuti vasarudze iyo polymer inonyatsokodzera mashandiro avo chaiwo.
3. Kuwedzera optimization
Kuvapo kwezvinowedzera kunokanganisa tembiricha yegelling yeHPMC. Iyo formulator ingangoda kukwirisa mhando uye kusungirirwa kwezvinowedzera kuti uwane inodiwa gel zvivakwa. Izvi zvinoda nzira yakarongeka uye kunyatsonzwisisa kwekudyidzana pakati peHPMC uye zvinowedzera.
Hydroxypropylmethylcellulose (HPMC) i polymer inoshanda yakawanda ine yakasarudzika gel zvimiro zvinokanganiswa nekupisa. Iyo tembiricha-inotsamira gelation yeHPMC ine zvakakosha kune akati wandei maindasitiri anosanganisira emishonga, kuvaka, uye zvizorwa. Kunzwisisa zvinhu zvinopesvedzera tembiricha yegelation, senge polymer concentration, huremu hwemamorekuru, uye kuvapo kwezvinowedzerwa, kwakakosha kune vanogadzira vari kutsvaga kukwirisa mashandiro egel kune chaiwo maapplication.
Sezvo tekinoroji ichifambira mberi uye tsvakiridzo yesainzi yepolymer inofambira mberi, kumwe kunzwisiswa kwehunhu hunotsamira tembiricha hweHPMC kunogona kutungamira mukugadzirwa kwemaitiro matsva nemashandisirwo. Iko kugona kukwenenzvera-tune gel zvivakwa kunovhura mikana mitsva yekugadzira zvinhu zvine zvakagadziridzwa zvivakwa, zvichibatsira kufambira mberi mukuendesa zvinodhaka, biomaterials uye mamwe minda.
Nguva yekutumira: Jan-11-2024