Hydroxypropyl methylcellulose HPMC isiri-ionic cellulose yakasanganiswa ether pakati peether dzakasiyana dzakasanganiswa ine ionic methylcarboxymethylcellulose. Haiite neheavy metal. Misiyano yezvinyorwa zvehydroxypropyl methylcellulose, hydroxypropyl methylcellulose, uye hydroxypropyl content ratio uye viscosity yeokisijeni isina gene ine marudzi akasiyana zvachose maererano nekuita. Semuenzaniso, mhando dzine yakakwira methoxyl zvemukati uye yakaderera hydroxypropyl zvemukati zvine maitiro akasiyana. Pedyo nemethylcellulose uye yakaderera methoxy yemukati mhando. Kuenzaniswa nemhando dzine yakakwira hydroxypropyl zvemukati, kuita kwayo kuri padyo neiyo yehydroxypropyl methylcellulose inogadzirwa. Zvisinei, kunyange zvazvo yakasiyana-siyana iine zvishoma zvishoma zveboka re hydroxypropyl kana zvishoma zveboka re methoxy, kune misiyano mikuru mukunyungudika mune organic solvents kana flocculation tembiricha mune aqueous mhinduro.
1. Solubility yehydroxypropyl methylcellulose
Solubility ye hydroxypropyl methylcellulose mumvura Hydroxypropyl methylcellulose ichokwadi propylene oxide (methylhydroxypropyl ring) yakagadziridzwa methylcellulose, saka ichine zvinhu zvakafanana nemethylcellulose Iine zvinhu zvakafanana zvekunyungudika mumvura inotonhora asi isinganyungudika mumvura inopisa. Nekudaro, tembiricha yegelling yeyakagadziridzwa hydroxypropyl mumvura inopisa yakakwira zvakanyanya kupfuura iyo yemethylcellulose. Semuenzaniso, 2% hydroxypropyl methylcellulose aqueous solution ine methoxy group content DS=0.73 uye hydroxypropyl group content MS=0.46 ine viscosity ye500mpa pa20°C. Tembiricha yegel yechigadzirwa cheS iri pedyo ne100°C, nepo iyo yemethylcellulose patembiricha imwe chete ingangoita 55°C. Kana iri yekunyungudika kwayo mumvura, yakagadziridzwawo zvakanyanya. Semuenzaniso, mushure mekunge hydroxypropyl methylcellulose yakapwanyika (chimiro chechidimbu chiri 0.2 ~ 0.5mm, viscosity ye4% yemvura pa20 ° C ndeye 2pA · S, inogona kushandiswa pakupisa kwekamuri pasina kutonhora. Inonyungudika nyore nyore mumvura).
(2) Kunyungudika kwehydroxypropyl methylcellulose mu organic solvents Kunyunguduka kwehydroxypropyl methylcellulose mu organic solvents zvakare kuri nani pane iyo yemethylcellulose. Methylcellulose inoda methoxy substitution degree ye 2.1 Zvigadzirwa zviri pamusoro zvine high-viscosity hydroxypropyl methylcellulose ine hydroxypropyl MS=1.5~1.8 uye methoxy DS=0.2~1.0, ine dhigirii rekutsiva rinopfuura 1.8, uye rinonyungudika nyore mu anhydrous uye anhydrous ethanol mhinduro. Thermoplastic uye mvura-soluble. Iyo zvakare inonyungudika mu chlorinated hydrocarbons senge methylene chloride uye chloroform, uye organic solvents senge acetone, isopropyl doro uye diacetone doro. Kunyungudika kwayo muorganic solvents kuri nani pane kunyungudika kwemvura.
2. Zvinhu zvinokanganisa viscosity yehydroxypropyl methylcellulose
Hydroxypropyl methylcellulose viscosity factor The standard viscosity measurement ye hydroxypropyl methylcellulose yakafanana nemamwe ma cellulose ethers, uye inopimwa pa 20 ° C ne 2% aqueous solution seyero. Iyo viscosity yechigadzirwa chimwe chete inowedzera sezvo kuwedzera kunowedzera. Kune zvigadzirwa zvine huwandu hwakafanana uye huremu hwakasiyana hwemamorekuru, chigadzirwa chine uremu hukuru hwemamorekuru chine viscosity yakakwirira. Hukama hwayo nekupisa hwakafanana neyemethylcellulose. Kana tembiricha ichikwira, viscosity inotanga kuderera, asi kana yasvika kune imwe tembiricha, viscosity inomuka kamwe kamwe uye gelation inoitika. Low viscosity zvigadzirwa zvine yakakwirira gelling tembiricha pane yakakwirira viscosity zvigadzirwa. Iyo gel point haina kungoenderana chete neiyo viscosity ye ether, asi zvakare yakabatana neyakaumbwa chiyero che methoxy uye hydroxypropyl mapoka muether uye yakazara dhigirii yekutsiva. Zvinofanira kucherechedzwa kuti hydroxypropyl methylcellulose zvakare pseudoplastic; mhinduro dzayo dzakagadzikana kana dzakachengetwa pakamuri tembiricha uye hadziratidzi kuderera kwe viscosity, kunze kwekunge enzymatic degradation.
3. Hydroxypropyl methylcellulose is acid uye alkali resistant
Hydroxypropyl methylcellulose iasidhi uye alkali inodzivirira. Hydroxypropyl methyl cellulose iasidhi uye alkali inodzivirira. Iyo inowanzo kugadzikana uye haizokanganiswe neiyo pH kukosha muhuwandu hwePH2 ~ 12. Inogona kumirisana nehumwe huwandu hweasidhi isina simba, senge formic acid, acetic acid, uye lemon. Acid, succinic acid, phosphoric asidhi asi yakadzika asidhi ine mhedzisiro yekudzikisa viscosity. Alkali yakadai se caustic soda, caustic potassium, uye lime mvura haina mhedzisiro pairi, asi mhedzisiro yekuwedzera zvishoma viscosity yemushonga inozoderera zvishoma nezvishoma gare gare.
4. Hydroxypropyl methylcellulose inogona kusanganiswa
Hydroxypropyl methylcellulose mhinduro inogona kusanganiswa nemvura-inonyungudika polymer komisheni kuita yunifomu uye yakajeka mhinduro ine yakakwira viscosity. Aya mapolymer compounds anosanganisira polyethylene glycol, polyvinyl acetate, polysiloxane, polymethyl vinyl siloxane, hydroxyethyl cellulose uye methyl cellulose. Natural polymer compounds senge acacia gum, mhashu yebhinzi gum, mhashu, nezvimwewo zvinewo musanganiswa wakanaka. mhinduro yayo. Hydroxypropyl methylcellulose inogonawo kusanganiswa ne stearic acid kana mannitol palmitate kana sorbitol, uye inogonawo kusanganiswa ne glycerin, sorbitol uye mannitol. Izvi zvinosanganiswa zvinogona kushandiswa se hydroxypropyl methylcellulose plasticizers agent.
5. Hydroxypropyl methylcellulose haina kunyungudika mumvura
Hydroxypropyl methylcellulose haina kunyungudika mumvura-soluble cellulose ethers uye inogona kuve pamusoro-yakabatana-yakabatana nealdehydes, zvichiita kuti idzi ether-soluble ethers dziwedzere mumushonga uye dzive dzisina kunyungudika mumvura. Uye ita hydroxypropyl methylcellulose insoluble mu aldehydes, formaldehyde, glyoxal, succinic acid, dialdehyde, etc. Paunenge uchishandisa formaldehyde, kunyanya kukoshesa kunofanira kubhadharwa kune pH kukosha kwemhinduro. Pakati pavo, glyoxal inobata nekukurumidza, saka inoshandiswa muindasitiri Glyoxal inowanzoshandiswa semuchinjiro wekubatanidza mukugadzira. -Crosslinking agent. Chiyero chemhando iyi ye-cross-linking agent mumhinduro ndeye 0.2% kusvika 10% yehuwandu hweether, uye yakanakisisa i7% kusvika 10%. Kana glyoxal ikashandiswa, 3.3% kusvika 6% ndiyo inonyanya kukodzera. Iyo yakawanda yekurapa tembiricha ndeye 0 ~ 30 ℃ uye nguva iri 1 ~ 120min. Iyo yekuyambuka-inobatanidza reaction inoda kuitwa pasi pemamiriro e acidic. Kazhinji, inorganic yakasimba asidhi kana organic carboxylic acid inowedzerwa kune mhinduro kugadzirisa pH yemhinduro kusvika pa2 kusvika 6, zviri nani pakati pe4 ne6, uyezve aldehydes inowedzerwa kuita muchinjiko-inobatanidza reaction. Maasidhi anoshandiswa anosanganisira hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, glycolic acid, succinic acid kana citric acid, pakati peiyo formic acid kana acetic acid ndiyo yakanyanya kunaka, uye formic acid ndiyo yakanyanya kunaka. Acids uye aldehydes zvinogona zvakare kuwedzerwa panguva imwe chete kuyambuka-kubatanidza mhinduro mukati meinodiwa pH renji. Kuita uku kunowanzo shandiswa mudanho rekupedzisira rekugadzirisa cellulose ether kuita kuti cellulose ether isanyungudika uye kufambisa kugezwa nekucheneswa ne 20 ~ 25°C mvura. Paunenge uchishandisa chigadzirwa, iwe unogona kuwedzera alkaline zvinhu kune chigadzirwa chekugadzirisa kugadzirisa pH yemhinduro kuti ive alkaline kuitira kuti chigadzirwa chikurumidze kuparara mumhinduro. Iyi nzira inogonawo kushandiswa kana firimu rakagadzirirwa uchishandisa cellulose ether solution uyezve firimu rinogadziriswa kuita firimu risinganyunguriki.
6. Hydroxypropyl methylcellulose anti-enzyme
Iyo cellulose inotorwa kubva kuhydroxypropyl methylcellulose ndeye theoretically inopikisa ma enzymes. Semuenzaniso, rimwe nerimwe boka reanhydroglucose rakasungwa zvakasimba neboka rinotsiva uye harisi nyore kukukurwa kwehutachiona uye hutachiona. Zvisinei, chaizvoizvo, kukosha kwekutsinhanisa kwechigadzirwa chakapedzwa kunodarika 1. Inogonawo kuderedzwa nema enzymes, izvo zvinoratidza kuti dhigirii yekutsiviwa kweboka rimwe nerimwe muketani ye cellulose haina kuenzana, uye ma microorganisms anogona kukanganisa mapoka ari pedyo asina kuchinjwa anhydroglucose kuti aumbe. shuga, iyo inogona kutorwa nema microorganisms sechikafu. Naizvozvo, kana dhigirii rekutsiva ether ye cellulose richiwedzera, kushorwa kwe cellulose ethers kukurwisa enzymatic kuchawedzera. Zvinonzi pasi pemamiriro ezvinhu akadzorwa, hydroxypropyl methylcellulose (DS = 1.9), methylcellulose (DS = 1.83), methylcellulose (DS = 1.66), hydroxyethylcellulose (1.7%) Izvo zvakasara viscosities 13.2%, 7.3%, 3.8% uye 1.8% zvichiteerana. Hydroxypropyl methylcellulose ine simba rekurwisa enzyme. Zvinogona kuonekwa kuti hydroxypropyl methylcellulose ine yakanakisa enzyme kuramba, pamwe chete nekupararira kwayo kwakanaka, kukora uye kugadzira mafirimu, inogona kushandiswa mu emulsion coatings, nezvimwewo, uye kazhinji haidi kuwedzera kwekuchengetedza. Zvisinei, kuitira kudzivirira mhinduro kubva pakuchengetedza kwenguva refu kana kusvibiswa kwekunze kwekunze, zvidziviriro zvinogona kuwedzerwa, uye kusarudzwa kwezvidziviriro zvinogona kugadziriswa zvichienderana nezvinodiwa zvekupedzisira zvekugadzirisa. Phenylmercuric acetate uye manganese fluorosilicate zvinochengetedza zvinobudirira, asi zvine chepfu uye zvinofanirwa kubatwa nehanya. Kazhinji, 1 kusvika ku5 mg ye phenylmercuric acetate inogona kuwedzerwa kune rimwe nerimwe remhinduro.
7. Kuita kwehydroxypropyl methylcellulose membrane
Hydroxypropyl methylcellulose film-forming properties Hydroxypropyl methylcellulose ine yakanakisa kugadzira firimu. Kana mhinduro yayo ine aqueous kana organic solvent solution yakaputirwa pandiro yegirazi, inova isina ruvara, yakajeka uye yakaoma firimu mushure mekuoma. . Iine hunyoro hwakanaka hwekudzivisa uye inoramba yakasimba pakupisa kwepamusoro. Kana hygroscopic plasticizers yakawedzerwa, kureba uye kuchinjika kunogona kuvandudzwa, uye kuchinjika kunogona kuvandudzwa. Plasticizers akadai glycerol uye sorbitol ndiyo inonyanya kukodzera. Iyo general solution yekumisikidza i2% ~ 3%, uye iyo plasticizer dosage i10% ~ 20% ye cellulose ether. Kana iyo plasticizer yemukati ichidikanwa kuve yakakwira, colloid syneresis ichaitika pasi pehunyoro hwepamusoro. Kusimba kwekusimba kwefirimu neplasticizer yakawedzerwa yakawanda kudarika iyo yefirimu isina plasticizer, uye inowedzera nehuwandu hweplasticizer yakawedzerwa. Iyo hygroscopicity yefirimu inowedzerawo nehuwandu hweplasticizer.
Nguva yekutumira: Feb-01-2024