Hydroxypropyl methylcellulose (HPMC) i polymer inoshanda zvakasiyana-siyana inoshandiswa zvakanyanya mumaindasitiri akasiyana siyana, kusanganisira mishonga, kuvaka, chikafu, uye zvizorwa. Hunhu hwayo hwakasiyana hunoita kuti ive yakakosha mumashandisirwo kubva kuhurongwa hwekuendesa zvinodhaka kusvika kune simende zvinhu. HPMC inotorwa kubva ku cellulose, yakasikwa polymer inowanikwa muzvirimwa, uye kugadzirwa kwayo kunosanganisira kugadziridzwa kwemakemikari kuti uwane chaiwo maitiro.
HPMC yakakamurwa kuita mamakisi akati wandei, imwe neimwe iine akasiyana zvivakwa uye mashandisirwo. Aya mamakisi anosiyana mumaparamendi akadai semamorekuru huremu, dhigirii rekutsiva, uye viscosity. Kunzwisisa misiyano iyi kwakakosha pakusarudza giredhi rakakodzera reimwe application. Ngationgororei mukati akasiyana mamakisi eHPMC uye mashandisiro azvo.
Magiredhi eViscosity:
HPMC inowanikwa mune akasiyana viscosity mamakisi, kazhinji kubva pasi kusvika pakakwirira viscosity. Iyo viscosity yeHPMC mhinduro zvinoenderana nezvinhu zvakaita semamorekuru uremu uye dhigirii rekutsiva.
Low viscosity mamakisi anowanzo shandiswa muzvishandiso zvinoda kukurumidza kunyungudika uye kuderera kwe tembiricha ye gelation, senge mumishonga yemapiritsi anoburitswa nekukurumidza.
Yakakwira viscosity mamakisi akakodzera kune maapplication anoda gobvu gels kana kuburitswa kwenguva refu, senge yakamira-yakaburitswa maumbirwo mumishonga.
Dhigirii reKutsiva (DS):
DS inoreva huwandu hweavhareji yehydroxypropyl uye methoxy substituents paanhydroglucose unit mucheni ye cellulose. Inobata solubility, gelation, uye film-forming properties yeHPMC.
Magiredhi ane epamusoro DS kukosha anowanzo ratidza yakagadziridzwa kunyungudika kwemvura uye kuumbwa kwemafirimu, zvichiita kuti aenderane nekushandisa senge firimu rekuputira mumishonga kana seanokora muzvigadzirwa zvekudya.
Yakaderera DS mamakisi anogona kupa zvirinani kugadzikana kwekupisa uye kuchengetedza mvura zvivakwa, zvichiita kuti ive yakanakira maapplication muzvinhu zvekuvaka senge zvinonamira mataira kana zvigadzirwa zvegypsum.
Particle Size:
HPMC inogona kugadzirwa mumhando dzakasiyana siyana, izvo zvinopesvedzera zvivakwa zvakaita sekupararira, kuyerera, uye magadzirirwo mumagadzirirwo.
Yakanaka particle saizi mamakisi anowanzo kufarirwa mumashandisirwo anoda kutsetseka kwemavara uye yunifomu kupararira, senge mune zvekuzora uye zvigadzirwa zvekuchengeta munhu.
Coarser mamakisi anogona kufarirwa mumashandisirwo panodiwa kuchengetedzwa kwemvura kwakagadziridzwa kana kumiswa zvivakwa, senge musanganiswa wakaoma dhaka kana majoini makomisheni.
Kuchena uye Kutevedzwa Kwemitemo:
HPMC mamakisi akagadzirirwa mishonga uye chikafu mashandisirwo anofanirwa kuzadzisa zvakaomesesa kuchena zviyero uye zvinodikanwa zvekutonga.
Pharmaceutical-giredhi HPMC inoedzwa zvakakwana kuti ive nechokwadi chekutevedzera pharmacopeial zviyero zvine chekuita nekuchena, kusavapo kwetsvina, uye kuenderana nezvimwe zvinobuda.
Chikafu-giredhi HPMC inofanirwa kutevedzera mirau yakagadzwa nezviremera zvakaita seFDA kana EFSA kuve nechokwadi chekuchengetedzwa kwekushandisa uye kutevedzera mirairo yekuwedzera chikafu.
Specialized Grades:
Mamwe mamakisi eHPMC akagadzirirwa mashandisirwo chaiwo, akadai seakaramba achiburitswa matrices, anodzorwa dhizaini masisitimu, kana ophthalmic formulations.
Aya magiredhi akasarudzika anogona kuwedzera kugadziridzwa kana kugadziridzwa kuti ape chaiwo mashandiro, senge yakagadziridzwa mucoadhesion, yakakwidziridzwa bioavailability, kana akawedzera kuburitswa profiles.
Sarudzo yegiredhi reHPMC zvinoenderana nezvinodiwa zvechikumbiro chakatarisirwa, tichifunga zvinhu zvakaita seviscosity, dhigirii rekutsiva, saizi yechikamu, kuchena, uye chero hunyanzvi hwekuita hunodiwa. Kusarudza giredhi rakakodzera kunovimbisa kuita kwakaringana uye hunhu hunodiwa muchigadzirwa chekupedzisira, ingave kugadzirwa kwemishonga, zvekuvaka, chigadzirwa chechikafu, kana zvizorwa.
Nguva yekutumira: May-24-2024