HPMC inoshandiswa mumadonhwe eziso

Hydroxypropyl methylcellulose (HPMC) ipolymer inoshandiswa zvakanyanya muindasitiri yemishonga, kunyanya mukugadzirwa kwemishonga yemaziso senge madonhwe emaziso. Madonhwe eziso anoshandiswa kurapa akasiyana siyana senge ziso rakaoma, glaucoma, uye allergies. HPMC inogona kushandiswa mumadonhwe emeso sechinhu chinosimbisa viscosity, mucoadhesive agent, uye inodzivirira. Muchikamu chino, tichaongorora kushandiswa kweHPMC mumadonhwe eziso zvakadzama.

Viscosity-enhancing agent

Rimwe remabasa ekutanga eHPMC mumadonhwe eziso nderekusimudzira viscosity yavo. Viscosity chinhu chakakosha parameter mune ophthalmic formulations sezvo ichibatsira kuve nechokwadi chekuti kuumbwa kunogara pameso emeso kwenguva yakakwana kuti ipe kurapa kwakanaka. Iyo viscosity yeHPMC mhinduro inotsamira pane molecular huremu hwepolymer uye dhigirii rekutsiva. HPMC mhinduro dzine huremu hwemamorekuru uye dhigirii rekutsiva zvine viscosity yepamusoro.

HPMC yakanakisa viscosity inosimudzira yemadonhwe eziso sezvo ichipa inoenderera-kuburitsa mhedzisiro nekuda kweiyo gel-kuumba zvivakwa. Iyo gel inoumbwa neHPMC mumadonhwe emeso inorebesa nguva yekubatana pakati pemushonga uye ziso, nekudaro kuvandudza kushanda kwemushonga. Uyezve, mhinduro dzeHPMC hadzina kudzima kuona, dzichivaita sarudzo yakanaka yemadonhwe eziso.

Mucoadhesive agent

Rimwe basa rakakosha reHPMC mumadonhwe eziso ndeye mucoadhesive zvimiro. HPMC ine hukama hwepamusoro hwemucus membranes, uye kushandiswa kwayo mumadonhwe emeso kunogona kubatsira kurebesa nguva yekugara yekuumbwa pameso emeso. Izvi zvinonyanya kubatsira mukurapa kwemaziso akaoma, apo kuratidzwa kwenguva refu kune kugadzirwa kunogona kubatsira kuderedza zviratidzo zvekuoma uye kusagadzikana.

Iyo mucoadhesive zvimiro zveHPMC zvinonzi zvakakonzerwa nekudyidzana kwayo nehydrogen bonding ne mucin glycoproteins. Mucin glycoproteins ndiyo inonyanya kuumba ye ocular surface mucus layer, iyo inoshanda sechidziviriro chekudzivirira. HPMC inogona kuomerera kune mucus layer uye kuwedzera nguva yekubatana yekugadzira pane ye ocular surface.

Mumiririri anodzivirira

Pamusoro peiyo viscosity-enhancing uye mucoadhesive properties, HPMC inoshandiswawo sechinhu chinodzivirira mumadonhwe eziso. Nzvimbo yemaziso inotapukirwa nekukuvara kubva kunze kwezvinhu zvakaita semwaranzi yeUV, kusvibiswa, uye mweya wakaoma. HPMC inogona kugadzira firimu rekudzivirira pamusoro penzvimbo yemaziso iyo inogona kubatsira kudzivirira maziso kubva kune izvi zvinokuvadza zvinhu.

Izvo zvinodzivirira zveHPMC zvinokonzerwa nekuumbwa kwejeri-kufanana nejeri pane ocular surface. Iyi nhanho inoshanda sechivharo chemuviri chinogona kubatsira kudzivirira kupinda kwezvinhu zvinokuvadza muziso. HPMC inogonawo kubatsira kunyaradza kumeso uye kuderedza zviratidzo zvekutsamwa kwemaziso.

Mhedziso

Mukupedzisa, HPMC ipolymer inoshanda zvakasiyana-siyana inowana kushandiswa kwakawanda mukugadzirwa kwemishonga yemaziso, kunyanya madonhwe emaziso. HPMC inogona kuvandudza viscosity yemadonhwe eziso, izvo zvinogona kubatsira kurebesa yavo yekuonana neiyo ocular pamusoro uye kuvandudza kushanda kwavo. HPMC's mucoadhesive properties inogona kubatsira kuwedzera nguva yekugara yekugadzirwa panzvimbo yemaziso, zvichiita kuti ive sarudzo yakanaka yekurapa yakaoma yeziso syndrome. HPMC inogona zvakare kudzivirira iyo yemaziso kubva kune zvinokuvadza zvekunze zvinhu nekugadzira inodzivirira layer. Kunyatsosarudzwa kweiyo yakakodzera HPMC giredhi uye kutarisisa kunogona kubatsira kuve nechokwadi chekuita kwakakwana uye kuenderana mukudonha kweziso.