HPMC mune Pharmaceuticals

The pharmaceutical excipient hydroxypropyl methyl cellulose (HPMC) isiri-ionic cellulose ether excipients, pari zvino ndiyo yakanyanya kushandiswa mudzimba nekune dzimwe nyika yemishonga inokonzeresa - a, semushonga wemushonga ane makore anopfuura makumi matatu enhoroondo. Haina kunhuhwirira, haina muchetura, inonyungudika mumvura inotonhora, gelation mumvura inopisa, yakaderera viscosity level HPMC inogona kushandiswa seyakanamatira, inonamira mumiririri uye yekumisa mumiririri yakakwirira viscosity level HPMC inogona kushandiswa kugadzirira yakasanganiswa zvinhu masisitimu inoenderera-kuburitswa. mahwendefa, akarembera-kuburitsa macapsules, hydrophilic gel chimiro chakasimba-chinoburitsa mapiritsi blocker, inodzorwa kuburitsa mumiririri uye pore channel agent.

Pharmaceutical excipient materials inoreva zvinhu zvinobatsira uye zvinosanganisa zvinoshandiswa mukugadzira uye kugovera mishonga. Chinhu, kunze kwechinhu chinoshanda, chakaongororwa zvine hungwaru kuitira kuchengetedza uye chinosanganisirwa muchigadzirwa chemishonga. Mishonga yemishonga ine mabasa anokosha ekugadzirisa, kubatsira kuparara, kunonoka uye kudzorwa kusunungurwa kunze kwekugadzira, kuzadza vatakuri nekuvandudza kugadzikana, izvo zvingakanganisa kunaka, kuchengeteka uye kushanda kwemishonga.

Hydroxypropyl methyl cellulose HPMC ndeimwe yemishonga mikuru yekubatsira mishonga kumba nekune dzimwe nyika, iyo yave ichishandiswa semishonga yekuwedzera kwemakore. Iyo haina kunhuhwirira, inoravira uye isina chepfu, inonyungudika mumvura inotonhora uye gelatinous mumvura inopisa. HPMC seyakasikwa hydrophilic polymer mishonga yekubatsira zvinhu, kwete chete inogona kushandiswa sehwendefa, granule, pill adhesive uye disintegrant, film coating material, inogona kushandiswa se colloidal agent uye suspension agent, inononoka kusunungurwa uye inodzorwa kusunungurwa kwekugadzirira blocker, inodzorwa. kusunungura agent uye pore-making agent, pamwe chete nemutakuri wekupararira kwakasimba.

HPMC sebhainda uye disintegrating agent. HPMC sebhainda inogona kuderedza kuonana Engle yemishonga, kuitira kuti zvinodhaka zvive nyore kunyorova, uye mvura yaro inogona kuwedzera mazana enguva, saka inogona kuvandudza zvakanyanya kuparara kana kusunungurwa kwemapiritsi. HPMC ine viscosity yakasimba, nekuti magadzirirwo ecrisp kana brittle hard raw materials anogona kusimudzira particle viscosity, kuvandudza kusimba kwayo. HPMC yakaderera viscosity inogona kushandiswa sebhainda uye disintegrating mumiririri, yakakwirira viscosity chete sebhainda, mari yacho inosiyana zvichienderana nemuenzaniso uye zvinodiwa, iyo yakawanda mari ndeye 2% -5%.

HPMC inoshandiswa seyakadzorwa kuburitsa zvinhu zvekugadzirira nemuromo. HPMC ndeye hydrogel framework zvinhu zvinowanzoshandiswa mukuchengetedza-kuburitswa gadziriro. HPMC ine low viscosity level (5 ~ 50mPa • s) inogona kushandiswa sebhainda, adhesive-enhancing agent uye kuturika rubatsiro, nepo HPMC ine high viscosity level (4000 ~ 100000mPa • s) inogona kushandiswa kugadzirira zvakasanganiswa zvinhu hurongwa hwakasimba-kuburitswa. mahwendefa, makapuleti anoramba achiburitswa, hydrophilic gel framework inosimudzira-kuburitswa mapiritsi se blocker. HPMC inogona kunyungudutswa mugastric enteric fluid, ine zvakanakira kudzvanya kwakanaka, kuyerera kwakanaka, simba rekurodha zvinodhaka uye hunhu hwekuburitsa zvinodhaka hazvikanganiswe nepH, nezvimwewo, yakakosha zvikuru hydrophilic inotakura zvinhu mukusimudzira kuburitswa kwegadziriro system, kazhinji. inoshandiswa se hydrophilic gel furemu uye yekuputira yekusimudzira kusunungurwa gadziriro, uye inoshandiswa mugastric inoyangarara kugadzirira, inosimudzira kuburitswa kwezvinodhaka firimu agent excipients.

HPMC seyekuputira firimu rekugadzira mumiriri. HPMC ine yakanaka firimu kuumba, inoumba läpinäkyvä firimu, kuoma, kugadzirwa hakusi nyore kunamatira, kunyanya kuti nyore mwando absorption, kusagadzikana zvinodhaka, nayo sechinhu chokuzvitsaura inogona kuvandudza zvikuru kugadzikana kwezvinodhaka, kudzivirira firimu discoloration. Kuenzaniswa negelatin firimu kuumbwa, HPMC firimu rine yakanaka kufanana uye chiedza transmittance. HPMC ine zvakasiyana-siyana zveviscosity tsanangudzo, kusarudzwa kwakakodzera, kupfekedza unhu, kutaridzika kuri nani pane kushandiswa kwezvimwe zvinhu, kunonyanya kushandiswa kwe2% -10%.

HPMC semumiriri wekumiswa. Kugadziriswa kwemvura yakamiswa kunowanzo shandiswa mumakiriniki edosi mafomu, ayo ari heterogeneous dispersion masisitimu emishonga isinganyungudika yakasimba mumhepo yekuparadzira media. Iko kugadzikana kwegadziriro inogadzirisa hutano hwekugadzirira mvura yakamiswa. HPMC colloidal mhinduro inogona kuderedza iyo yakasimba-yemvura interface tension, kuderedza pamusoro pemahara simba rezvimedu zvakasimba, kuitira kuti heterogeneous dispersion system iite kunge yakagadzikana, inyanzvi yekumisa mumiriri. HPMC inoshandiswa seyakakora yemadonhwe emeso, ine zvinyorwa zve 0.45% -1.0%.