HPMC yemushonga wemhuka

Hydroxypropyl methylcellulose (HPMC) i polymer inoshandiswa zvakanyanya muindasitiri yemishonga, uye inoshandiswawo mukugadzirira mishonga yemhuka. HPMC inonyungudika mumvura, isiri-ionic cellulose ether inotorwa kubva kune yakasikwa cellulose. Iyo yakachengeteka, biocompatible, uye biodegradable polymer iyo inoshandiswa kuvandudza kugadzikana, rheological properties, uye bioavailability yemishonga yemhuka. Muchikamu chino, tichakurukura zvivakwa uye mashandisirwo eHPMC mukurapa wemhuka.

Zvivakwa zveHPMC

HPMC is semi-synthetic polymer iyo inotorwa kubva ku cellulose. Iine huwandu hwezvinhu zvinoita kuti ive yakakodzera kushandiswa mumishonga yemhuka. Zvinhu izvi zvinosanganisira:

Kunyungudika kwemvura: HPMC inonyanya kunyungudika mumvura, zvinoreva kuti inogona kunyungudika nyore mumvura uye mamwe magadzirirwo emvura. Izvi zvinoita kuti zvive nyore kuisa mumishonga yemhuka.

Pseudo-plastiki maitiro: HPMC inoratidza pseudo-plastiki maitiro, zvinoreva kuti ndeye thixotropic uye shear-kutetepa. Iyi pfuma inobvumira kuti ideredze viscosity yekumisikidzwa kana ichiiswa kune shear stress, izvo zvinoita kuti zvive nyore kutonga veterinary mushonga.

Kugona kugadzira firimu: HPMC ine yakanaka yekugadzira firimu, izvo zvinoreva kuti inogona kuumba danda rekudzivirira pamusoro pezvimedu zvemushonga wezvipfuyo, izvo zvinobatsira kuvadzivirira kubva mukuora uye kuunganidzwa.

Mucoadhesive properties: HPMC ine mucoadhesive properties, zvinoreva kuti inogona kunamatira kune mucosal nzvimbo mumuviri. Ichi chivakwa chinonyanya kubatsira kune yemuromo uye nemhino yekuendesa zvinodhaka masisitimu, sezvo ichibvumira kwenguva yakareba yekuonana neye mucosal nzvimbo uye yakagadziridzwa kunyudzwa kwezvinodhaka.

Kushandiswa kweHPMC muVeterinary Medicine

HPMC inoshandiswa mumhando dzakasiyana dzemishonga yemhuka. Mamwe emamwe anonyanya kushandiswa eHPMC mukurapa wemhuka anosanganisira:

Kudzikamisa: HPMC inoshandiswa kuvandudza kugadzikana kwemishonga yemhuka. Inogona kubatsira kudzivirira kuunganidzwa kwechikamu, flocculation, uye sedimentation, izvo zvinogona kuvandudza hupenyu hwesherufu hwemushonga.

Rheological modification: HPMC inogona kushandiswa kugadzirisa rheological zvimiro zvemishonga yemhuka. Inogona kubatsira kuderedza viscosity yemishonga, iyo inogona kuita kuti zvive nyore kutungamirira.

Kuburitswa kunodzorwa: HPMC inogona kushandiswa kuwana inodzorwa kuburitswa kwemishonga kubva kumishonga yemhuka. Iyo firimu yekugadzira firimu yeHPMC inobvumira kuti iite chidziviriro chekudzivirira pamusoro pezvikamu zvemishonga, izvo zvinogona kuderedza kubudiswa kwechirwere mumuviri.

Bioavailability kusimudzira: HPMC inogona kuvandudza bioavailability yemishonga mumishonga yemhuka. Iyo mucoadhesive zvimiro zveHPMC inobvumira kuti ibatire kune mucosal nzvimbo mumuviri, izvo zvinogona kuvandudza kutorwa kwezvinodhaka uye bioavailability.

Kuravira masking: HPMC inogona kushandiswa kuvhara kuravira kusingafadzi kwemishonga mumishonga yemhuka. Izvi zvinonyanya kukosha pakugadzirwa kwemukanwa, sezvo zvichigona kuita kuti mushonga uwedzere kunakidza uye nyore kupa kumhuka.

Topical formulations: HPMC inoshandiswawo mumusoro maumbirwo emishonga yemhuka. Inogona kushandiswa seyakakora, stabilizer, uye emulsifier mumakirimu, mafuta ekuzora, uye gels. Iyo pseudo-plastiki maitiro eHPMC inobvumira kuti ivandudze kupararira uye kuenderana kweiyo topical kuumbwa.

Majekiseni ekugadzira: HPMC inogona zvakare kushandiswa mumajekiseni emushonga wemishonga yemhuka. Inogona kushandiswa seanomisa mumiriri uye viscosity enhancer kuvandudza kugadzikana uye rheological zvimiro zvejekiseni.

Mhedziso

Mukupedzisa, HPMC i polymer inoshanda zvakasiyana-siyana inoshandiswa zvakanyanya muindasitiri yemishonga, kusanganisira mukurapa kwezvipfuyo. Kunyungudika kwayo kwemvura, pseudo-plastiki maitiro, kugona kugadzira firimu, mucoadhesive zvivakwa, uye kuravira masking kugona kunoita kuti ive chinhu chakakosha mukugadzira mishonga yemhuka. HPMC inogona kuvandudza kugadzikana, rheological properties, bioavailability, uye palatability yemishonga yemhuka, zvichiita kuti zvive nyore kupa uye kunyatsoshanda mukurapa mhuka.