HPMC yekumisa giredhi remishonga

Hydroxypropyl methylcellulose (HPMC) i polymer inoshandiswa zvakanyanya muindasitiri yemishonga, kunyanya kune yayo zvivakwa mukugadzirira kumiswa. HPMC inonyungudika mumvura, isiri-ionic cellulose ether inotorwa kubva kune yakasikwa cellulose. Iyo yakachengeteka, biocompatible, uye biodegradable polymer iyo inoshandiswa kuvandudza kugadzikana, rheological zvimiro, uye bioavailability yekumiswa kwemishonga. Muchikamu chino, tichakurukura zvivakwa uye mashandisirwo eHPMC mukumisikidzwa kwegiredhi remishonga.

Zvivakwa zveHPMC

HPMC is semi-synthetic polymer iyo inotorwa kubva ku cellulose. Iine huwandu hwezvinhu zvinoita kuti ive yakakodzera kushandiswa mukumiswa kwemishonga. Zvinhu izvi zvinosanganisira:

Kunyungudika kwemvura: HPMC inonyanya kunyungudika mumvura, zvinoreva kuti inogona kunyungudika nyore mumvura uye mamwe magadzirirwo emvura. Izvi zvinoita kuti zvive nyore kubatanidza mukumiswa kwemishonga.

Pseudo-plastiki maitiro: HPMC inoratidza pseudo-plastiki maitiro, zvinoreva kuti ndeye thixotropic uye shear-kutetepa. Ichi chivakwa chinobvumira kuti chideredze viscosity yekumisikidzwa kana ichiiswa kune shear stress, izvo zvinoita kuti zvive nyore kutonga kumiswa.

Kukwanisa kugadzira firimu: HPMC ine yakanaka yekugadzira firimu, izvo zvinoreva kuti inogona kuumba chidziviriro chepamusoro pamusoro pezvimedu zvekumisikidza, izvo zvinobatsira kuvadzivirira kubva pakuora uye kuunganidzwa.

Mucoadhesive properties: HPMC ine mucoadhesive properties, zvinoreva kuti inogona kunamatira kune mucosal nzvimbo mumuviri. Ichi chivakwa chinonyanya kubatsira kune yemuromo uye nemhino yekuendesa zvinodhaka masisitimu, sezvo ichibvumira kwenguva yakareba yekuonana neye mucosal nzvimbo uye yakagadziridzwa kunyudzwa kwezvinodhaka.

Kushandiswa kweHPMC mune Pharmaceutical Giredhi Kumiswa

HPMC inoshandiswa mumhando dzakasiyana dzekumisa giredhi remishonga. Kumwe kunonyanya kushandiswa kweHPMC mukumiswa kwemishonga kunosanganisira:

Kugadzikana: HPMC inoshandiswa kuvandudza kugadzikana kwekumiswa kwemishonga. Inogona kubatsira kudzivirira kuunganidzwa kwechikamu, flocculation, uye sedimentation, izvo zvinogona kuvandudza hupenyu hwesherufu hwekumiswa.

Rheological modification: HPMC inogona kushandiswa kugadzirisa rheological zvimiro zvekumiswa kwemishonga. Inogona kubatsira kuderedza viscosity yekumisa, izvo zvinogona kuita kuti zvive nyore kutonga kumisa.

Kuburitswa kunodzorwa: HPMC inogona kushandiswa kuwana inodzorwa kuburitswa kwemishonga kubva mukumiswa kwemishonga. Iyo firimu yekugadzira firimu yeHPMC inobvumira kuti iite chidziviriro chekudzivirira pamusoro pezvikamu zvemishonga, izvo zvinogona kuderedza kubudiswa kwechirwere mumuviri.

Bioavailability kusimudzira: HPMC inogona kuvandudza bioavailability yemishonga mukumiswa kwemishonga. Iyo mucoadhesive zvimiro zveHPMC inobvumira kuti ibatire kune mucosal nzvimbo mumuviri, izvo zvinogona kuvandudza kutorwa kwezvinodhaka uye bioavailability.

Kuravira masking: HPMC inogona kushandiswa kuvhara kuravira kusingafadzi kwemishonga mukumiswa kwemishonga. Iyo firimu-kuumba kugona kweHPMC inobvumira kuti igadzire chidziviriro chakatenderedza zvidimbu zvezvinodhaka, izvo zvinogona kudzivirira kuburitswa kwemushonga mumuromo uye kuvhara kuravira kwayo.

Kufambirana nekuvandudzwa: HPMC inogona kuvandudza kuenderana kwemishonga mukumiswa kwemishonga. Iyo inonyungudika nemvura yeHPMC inobvumira kunyungudika mumvura uye mamwe aqueous mhinduro, iyo inogona kuvandudza kuenderana kwemushonga pamwe nezvimwe zvinobatsira mukumiswa.

Mhedziso

HPMC ipolymer inoshanda zvakasiyana-siyana inoshandiswa zvakanyanya muindasitiri yemishonga kune zvivakwa zvayo mukugadzirira kumiswa. Kunyungudika kwayo kwemvura, pseudo-plastiki maitiro, kugona kugadzira firimu, mucoadhesive zvivakwa, uye biocompatibility inoita kuti ive polima inobatsira yekudzikamisa kumiswa kwemishonga.