HPMC yeFirimu Coating

HPMC yeKuputira firimu ndiyo nzira yekugadzira firimu rakatetepa repolymer pamusoro pegadziriro yakasimba. Semuyenzaniso, akaturikidzana akatsiga polymer zvinhu zvakapfapfaidzwa zvakafanana pamusoro plain sheet nenzira yokupfapfaidza kuumba epurasitiki firimu layer akati wandei microns gobvu, kuitira kuti awane mhedzisiro yaunoda. Kuumbwa kweiyi firimu rekunze kwepiritsi ndeyekuti piritsi rimwe chete rinonamatira kune polymer coating zvinhu mushure mekupfuura nepakati penzvimbo yekupfapfaidza, uye yozogamuchira chikamu chinotevera chekuputira zvinhu mushure mekuoma. Mushure mekudzokorora kunamatira uye kuomeswa, kuvhara kunopedzwa kusvikira nzvimbo yose yekugadzirira yakavharwa zvachose. Firimu yekuputira ifirimu rinoenderera, ukobvu kazhinji pakati pe8 kusvika ku100 microns, imwe dhigirii yekunyungudika uye kuchinjika, inonamira zvakanyanya pamusoro pepakati.

Muna 1954, Abbott akagadzira bhechi rekutanga remapepa emafirimu anotengeswa, kubvira ipapo, nekuenderera mberi nekunatsiridza uye kukwana kwemidziyo yekugadzira uye tekinoroji, zvigadzirwa zvemafirimu epolymer zvakaburitswa, kuitira kuti tekinoroji yekupfekedza firimu yakakurumidza kugadzirwa. Kwete chete zvakasiyana-siyana, huwandu uye hutano hwemavara ekugadzira mavara akawedzera nekukurumidza, asiwo marudzi, mafomu uye maitiro ekugadzira teknolojia, midziyo yekupfekedza uye firimu rekuvhara pamwe nekuputira mapiritsi eTCM zvakagadziridzwa zvikuru. Naizvozvo, kushandiswa kwehunyanzvi hwekuputira firimu kwave kudiwa uye maitiro ekusimudzira emabhizinesi emishonga kuvandudza mhando yechigadzirwa.

Kushandiswa kwekutanga mufirimu yekuputira firimu kugadzira zvinhu, kuchine huwandu hukuru hwezvigadzirwa zvinoshandisa HPMChydroxypropyl methylcelluloseseMembrane zvinhu. Ndiko kucheneswaHPMCcellulose kubva kudonje lint kana huni pulp, uye sodium hydroxide solution kuratidza kuzvimba kwealkali cellulose, uyezve nechloromethane uye propylene oxide kurapwa kuti uwane methyl hydroxypropyl cellulose ether.HPMC, chigadzirwa chekubvisa tsvina mushure mekuoma, kupwanya, kuvhara. Kazhinji, yakaderera viscosity HPMC inoshandiswa sefilmCoating material, uye 2% ~ 10% solution inoshandiswa sekugadzirisa. Izvo zvisingabatsiri ndezvokuti viscosity yakakura zvikuru uye kuwedzera kwakasimba.

Chizvarwa chechipiri chekugadzirwa kwemafirimu ndeye polyvinyl doro (PVA). Polyvinyl doro inoumbwa nedorolysis ye polyvinyl acetate. Vinyl doro rekudzokorora mayunitsi haagone kushandiswa seanogadzirisa nekuti haakwane huwandu uye kuchena kunodiwa ku polymerization. Mu methanol, ethanol kana ethanol uye methyl acetate yakasanganiswa mhinduro ine alkali simbi kana inorganic acid se catalyst, hydrolysis inokurumidza.

PVA inoshandiswa zvakanyanya mukugadzira firimu. Nekuti hainyungudike mumvura patembiricha yekamuri, inowanzoputirwa ne20% yekupararira kwemvura. Iyo mhute yemvura uye oxygen permeability yePVA yakaderera pane HPMC neEC, saka iyo inovharira kugona kwemhute yemvura uye okisijeni yakasimba, inogona kuchengetedza zvirinani chip core.

Plasticizer inoreva chinhu chinogona kuwedzera plasticity yezvinhu zvekugadzira firimu. Zvimwe zvekugadzira firimu zvinoshandura maitiro avo emuviri mushure mekunge tembiricha yadzikira, uye kufamba kwema macromolecules yavo kunova kudiki, zvichiita kuti rukuvhute ruve rwakaoma uye rune brittle, kushaya kuchinjika kwakakodzera, uye nekudaro nyore kuputsika. Plasticizer yakawedzerwa kudzikisa tembiricha yegirazi (Tg) uye kuwedzera coating kushanduka. Anowanzo shandiswa plasticizers maamorphous mapolima ane huremu hwakakura hwemamorekuru uye hukama hwakasimba nezvinhu zvekugadzira firimu. Iyo insoluble plasticizer inobatsira kuderedza kupera kwekuvhara, nokudaro kuwedzera kugadzikana kwekugadzirira.

Zvinowanzotendwa kuti mashandiro eplasticizer ndeyekuti mamorekuru eplasticizer akaiswa mukati me polymer cheni, iyo inovharira kupindirana pakati pepolymer mamorekuru kusvika pamwero mukuru. Kudyidzana kuri nyore kana kupindirana kwepolymer-plasticizer kwakasimba kupfuura kupindirana kwepolymer-plasticizer. Saka, mikana yekuti zvikamu zvepolymer zvifambe zvinowedzerwa.

Chizvarwa chechitatu chemafirimu ekugadzira zvinhu ndeye plasticizer nemakemikari nzira yakabatanidzwa mufirimu inogadzira zvinhu polymer

Semuyenzaniso, IYO itsva yekugadzira firimu rekugadzira zvinhu Kollicoat® IR yakaunzwa neBASF ndeyekuti PEG inonamirwa nekemikari kune refu cheni yePVA polymer pasina kuwedzera plasticizer, saka inogona kudzivirira kutama kwedhamu mushure mekuputira.