Kugadzirira hydroxypropyl methylcellulose (HPMC) yekuputira mhinduro kunosanganisira akawanda matanho uye inoda kunyatsotarisisa kune zvakadzama. HPMC inowanzoshandiswa senge firimu rekuputira zvinhu mumaindasitiri emishonga uye ezvekudya. Coating solutions inoshandiswa pamapiritsi kana granules kuti ipe chidziviriro chekudzivirira, kuvandudza chitarisiko, uye kufambisa kumedza.
1. Nhanganyaya yeHPMC coating:
Hydroxypropylmethylcellulose (HPMC) inonzi cellulose-based polymer inotorwa kubva mumiti yemiti. Nekuda kweiyo firimu-kuumba uye kukora zvimiro, inoshandiswa zvakanyanya mumafirimu ekuputira mumaindasitiri emishonga uye ezvekudya.
2. Zvinhu zvinodiwa:
Hydroxypropyl methylcellulose poda
Natsa mvura
Zvigaba zvepurasitiki kana simbi isina tsvina
Kukurudzira midziyo (semuenzaniso magnetic stirrer)
Midziyo yekuyeresa (zvikero, masilinda ekuyeresa)
pH mita
Plastiki kana Stainless simbi yekupfeka pani
Hovhoni yemhepo inopisa
3.program:
Weresa iyo HPMC:
Nyatsoyera chiyero chinodiwa cheHPMC poda zvichibva pane inodiwa coating kuumbwa. Concentrations kazhinji iri pakati pe2% ne10%.
Gadzirira mvura yakachena:
Shandisa mvura yakacheneswa kuti uone kuti haina tsvina inogona kukanganisa kunaka kwekuputira. Mvura inofanira kunge iri pakamuri yekupisa.
Kupararira kweHPMC:
Zvishoma nezvishoma wedzera huremu hweHPMC hupfu kumvura yakacheneswa uchikurudzira nguva dzose. Izvi zvinodzivirira kuumbwa kwemasumbu.
Gadzirisa:
Gadzirisa musanganiswa uchishandisa magnetic stirrer kana imwe yakakodzera inobvongodza mudziyo kusvikira iyo HPMC poda yapararira mumvura.
pH kugadzirisa:
Edza pH yemhinduro yeHPMC uchishandisa pH mita. Kana zvichidikanwa, iyo pH inogona kugadziridzwa nekuwedzera shoma shoma yeasidhi kana chigadziko zvinoenderana. Iyo yakakwana pH yekupfekedza firimu kazhinji iri pakati pe5.0 kusvika 7.0.
Moisturizing uye kuchembera:
Iyo HPMC mhinduro inotenderwa hydrate uye zera kwenguva yakati rebei. Izvi zvinowedzera hupfumi hwekugadzira firimu. Nguva yekuchembera inogona kusiyana asi kazhinji iri pakati pe2 kusvika kumaawa 24.
sefa:
Sefa mhinduro yeHPMC kubvisa chero zvidimbu zvisina kunyungudika kana tsvina. Iyi nhanho yakakosha kuti uwane yakatsetseka, yakajeka yekuvhara mhinduro.
Viscosity kugadzirisa:
Edza viscosity yemhinduro uye uigadzirise kune yaunoda nhanho. Viscosity inokanganisa kufanana uye ukobvu hwekuputira.
Test kuenderana:
Edza kuenderana kwemhinduro yekuputira neiyo substrate (mapiritsi kana granules) kuve nechokwadi chekunamatira kwakakodzera uye kuumbwa kwemafirimu.
Coating process:
Shandisa pani yekupotera yakakodzera uye shandisa muchina wekupotera kuisa iyo HPMC yekupotera mhinduro kumapiritsi kana granules. Gadzirisa kumhanya kwepoto uye tembiricha yemhepo kuti unyatso kupfekedza.
kuomesa:
Mahwendefa akaputirwa kana magranules akaomeswa muhovhoni-inodzorwa nemhepo inopisa kusvika iyo yaidiwa yekuputira ukobvu yaitwa.
QC:
Ita yemhando yekudzora yemhando yezvigadzirwa zvakavharwa zvinosanganisira kutaridzika, ukobvu uye kunyungudika zvivakwa.
4.mumhedziso:
Kugadzirira kweHPMC coating solutions kunosanganisira akatevedzana matanho chaiwo ekuona kunaka uye kushanda kweiyo coating. Kuomerera kune zvakatemwa maitiro uye maitiro ekugadzirisa hutano zvakakosha kuti uwane mhedzisiro uye yakavimbika mhedzisiro mumaindasitiri emishonga uye ezvekudya. Gara uchitevera Yakanaka Kugadzira Maitiro (GMP) uye yakabatana nhungamiro panguva yekupfeka.
Nguva yekutumira: Jan-18-2024