Kugadzirisa chiyero chekugadzirisa kweHPMC mukuputira piritsi inzira yakaoma inosanganisira kunzwisisa muviri uye kemikari zvimiro zveHPMC uye nzira yekuzadzisa inodiwa coating kuita nekugadzirisa kuumbwa.
Sarudza yakakodzera HPMC viscosity yakatarwa: HPMC ine zvakasiyana-siyana zveviscosity yakatarwa. HPMC ine akasiyana viscosities inokanganisa iyo yakasimba yemukati uye firimu-kugadzira zvimiro zvejasi. Low viscosity HPMC inobatsira kuwedzera solids content, asi ingangoda kusanganiswa nemamwe mamakisi eHPMC kutora mukana weayo akasiyana emuviri zvimiro.
Shandisa musanganiswa weakawanda HPMC maratidziro: Mune akakwenenzverwa mafomula, akati wandei maHPMC eakasiyana maratidziro anowanzo shandiswa panguva imwe chete kushandisa zvizere iwo akasiyana emuviri zvimiro. Uku kusanganiswa kunovandudza kupfekedza kushanda uye kunaka.
Kuwedzera plasticizers: Plasticizers yakadai se polyethylene glycol (PEG), triethyl citrate, nezvimwewo inogona kuvandudza kushanduka kwefirimu uye kuderedza girasi rekuchinja kwegirazi (Tg), nokudaro nekuvandudza zvinhu zvemuviri zvekuputira.
Funga nezve kusungirirwa kwemhinduro yekuputira: Iyo yakasimba yemukati yemushonga wekuputira ine mhedzisiro yakakura pakubata zvakanaka. Kuputira mvura ine yakakwira yakasimba yemukati inogona kuderedza nguva yekuputira uye kunatsiridza kugadzirwa kwakanaka. Semuenzaniso, kana uchishandisa Kollicoat® IR-based materials, coating formulation concentrations inogona kunge yakakwira se30%.
Gadzirisa maparamendi ekuputira: Kupfekedza maitiro maparamendi, akadai seyekupfapfaidza, tembiricha yemhepo inopinza, tembiricha yepoto, kudzvanywa kweatomu, uye kumhanya kwepoto, zvinokanganisa kunaka kwekupfeka uye kufanana. Nekugadzirisa aya ma parameter, optimal coating results inogona kuwanikwa.
Kushandiswa kweNew low low molecular weight HPMC: New low low molecular weight HPMC (yakadai sehypromellose 2906, VLV hypromellose) inogona kuvandudza nzira yekuputira piritsi uye kuderedza mari. Nekusanganisa neyakajairwa HPMC, yakaringana coating zvivakwa zvinogona kuwanikwa mune yakakwira-yekuputira machira, pasina nyaya dzekunamira pasi peyakapfava yekupfekedza mamiriro, uye yakasimba piritsi remufirimu.
Funga kugadzikana kwezvinhu zvekuputira: HPMCP ipolymer yakagadzikana zvikuru iyo kugadzikana kwayo kunochengetedzwa pasi pemvura yakakwirira-mamiriro ezvinhu, izvo zvakakosha kuti zvive nechokwadi chemhando yemapiritsi akavharidzirwa panguva yekuchengetedza.
Gadzirisa nzira yekugadzirira yekugadzirisa mhinduro: Muchiitiko chekugadzirira zvakananga musanganiswa wakasanganiswa, zvishoma nezvishoma uwedzere HPMCP powder kune yakasanganiswa solvent kuti urege kuumbwa kweagglomerates. Zvimwe zvinongedzo mune yekubikira mhinduro senge plasticizers, pigment uye talc inodawo kuwedzerwa sezvinodiwa.
Funga nezvezvimiro zvemushonga: Kunyungudika uye kugadzikana kwemushonga kuchapesvedzera kusarudzwa kwekuputira kuumbwa. Semuyenzaniso, kune maphotosensitive zvinodhaka, maopacifiers angangodiwa kudzivirira mushonga kubva mukuora.
Ita in vitro ongororo uye kugadzikana zvidzidzo: Kuburikidza ne in vitro dissolution bvunzo uye kudzikama zvidzidzo, kuita kwemapiritsi akavharidzirwa anogona kuongororwa kuti ive nechokwadi chekushanda uye kugadzikana kweiyo coating formula mumashandisirwo anoshanda.
Nekunyatsotarisisa zvinhu zviri pamusoro uye kugadzirisa zvinoenderana neyakagadzika mamiriro ekugadzira uye hunhu hwezvinodhaka, iyo formula reshiyo yeHPMC mukuputira piritsi inogona kugadziridzwa kuti ibudirire, yunifomu uye yakagadzikana coating mhedzisiro.
Nguva yekutumira: Oct-29-2024