Hydroxypropylcellulose (HEC) inotorwa kubva kune cellulose, yakasikwa polymer inowanikwa muchirimwa sero madziro. HPC inoshandiswa zvakanyanya mumaindasitiri akasiyana akadai semishonga, zvizorwa uye maindasitiri ezvekudya nekuda kweakanakisa kugadzira firimu uye kukora zvivakwa. Iyo synthesis yehydroxypropylcellulose inosanganisira akawanda matanho uye maitiro anogona kuve akaomarara.
Nhanganyaya yehydroxypropylcellulose:
1. Kushandisa cellulose sechinhu chekutanga:
Nzvimbo huru dze cellulose zvinhu zvezvirimwa zvakaita sehuni pulp kana donje. Cellulose is linear polymer inoumbwa neglucose units akabatanidzwa ne β-1,4-glycosidic bonds. Iyo ine yakakwira dhigirii yepolymerization, ine zviuru zveglucose mayunitsi anoumba maketani akareba.
2. Etherification reaction:
Iyo synthesis yehydroxypropylcellulose inosanganisira kuunzwa kwemapoka ehydroxypropyl mumusana we cellulose kuburikidza ne etherification. Kuita uku kunowanzo sanganisira kushandiswa kwepropylene oxide seyo alkylating agent.
Cellulose + propylene oxide → alkali-catalyzed hydroxypropyl cellulose + by-product cellulose + propylene oxide alkali-catalyzed hydroxypropyl cellulose + by-product
Base catalysis yakakosha kusimudzira maitiro pakati pe cellulose hydroxyl mapoka uye propylene oxide. Iyi nhanho inowanzoitwa pasi pemamiriro akadzorwa kuti ive nechokwadi chinodiwa dhigirii rekutsiva (DS) yemapoka ehydroxypropyl pacheni ye cellulose.
3. Hydroxypropylation:
Hydroxypropylation inosanganisira kuwedzera kwemapoka ehydroxypropyl kune cellulose musana. Iyi shanduko inopa yakagadziridzwa solubility uye zvimwe zvinodikanwa zvivakwa kune cellulosic polymer. Mamiriro ekuita, anosanganisira tembiricha, kudzvanywa uye nguva yekuita, anodzorwa nekuchenjera kuti awane chishuwo chechigadzirwa.
4. Alkali kurapwa:
Mushure me hydroxypropylation, alkaline kurapwa inowanzoshandiswa kuderedza chero yasara acidic tsvina uye kugadzirisa pH yemusanganiswa wekuita. Danho iri rakakosha kune rinotevera rekucheneswa.
5. Matanho ekunatsa:
Mushure mekuita kwe etherification, matanho akawanda ekuchenesa anowanzoitwa kuti awane yakakwirira-kuchena hydroxypropylcellulose. Matanho aya anogona kusanganisira:
Geza: Geza musanganiswa wekuita kuti ubvise zvakasara reagents, ne-zvigadzirwa uye isina kubatwa cellulose.
Filtration: Filtration inoshandiswa kuparadzanisa tsvina yakasimba kubva musanganiswa wekuita.
Kuomesa: Iyo yakanyorova hydroxypropyl cellulose inozoomeswa kubvisa chero hunyoro hwasara.
6. Molecular weight control:
Huremu hwemamorekuru hwehydroxypropylcellulose hunogona kudzorwa panguva yekubatanidza kuti igadzirise zvimiro zvayo kune chaiwo mashandisirwo. Izvi zvinowanikwa nekugadzirisa maitiro ekuita, akadai sehuwandu hwema reagents uye nguva yekuita.
Kugadzirwa kwemaindasitiri:
1. Zvichiitika kana kuti zvinoramba zvichiitika:
Kugadzirwa kwehydroxypropyl cellulose kunogona kuitwa mubatch kana kuenderera maitiro. Iyo batch process yakanakira diki-scale kugadzirwa, nepo iyo inoenderera ichinyanya kukodzera kugadzirwa kwakakura.
2. Kudzora kunaka:
Matanho ekudzora emhando anoitwa pamatanho ese ekugadzira maitiro kuti ave nechokwadi chekuenderana uye kuchena kwechigadzirwa chekupedzisira. Maitiro ekuongorora akadai sechromatography, spectroscopy uye rheological zvidzidzo zvinoshandiswa kuongorora akakosha paramita senge degree rekutsiva, huremu hwemamorekuru uye kuchena.
Kushandiswa kweHydroxypropyl Cellulose:
1. Indasitiri yemishonga:
Hydroxypropylcellulose inoshandiswa zvakanyanya mukugadzirira kwemishonga sebhainda, disintegrant uye inodzorwa kuburitsa mumiririri. Kupindirana kwayo nemishonga yakasiyana-siyana uye inertness yayo inoita kuti ive mubatsiri wakasiyana-siyana.
2. Indasitiri yezvekuzora:
Muindasitiri yezvizorwa, hydroxypropylcellulose inoshandiswa mukugadzira zvigadzirwa zvekuchengeta bvudzi, makirimu eganda uye zvimwe zvigadzirwa zvekuchengeta munhu. Iyo firimu-inogadzira zvinhu inoita kuti ive yakakosha muzvigadzirwa zvekuchengetedza bvudzi.
3. Indasitiri yezvekudya:
Muindasitiri yechikafu, hydroxypropylcellulose inoshandiswa seyakakora uye gelling agent. Inowanikwa mune zvakasiyana-siyana zvekudya uye inobatsira kuvandudza maitiro avo uye kugadzikana.
Iyo synthesis yehydroxypropylcellulose inosanganisira etherification ye cellulose nekuwedzera kwemapoka ehydroxypropyl. Mhedzisiro yacho inowanzogadziriswa nenheyo, inoteverwa nematanho ekuchenesa kuti uwane chigadzirwa chakanyanya kuchena. Kugadzirwa kwemaindasitiri kunogona kuitwa nebatch kana kuenderera maitiro ane akasimba emhando yekudzora matanho. Hydroxypropylcellulose ine huwandu hwakasiyana hwekushandisa mumishonga yemishonga, cosmetic uye chikafu maindasitiri nekuda kweayo akasiyana zvivakwa uye kuita zvakasiyana. Iko kuenderera mberi kwekuvandudza kwemaitiro ekugadzira uye kuvandudzwa kwezvishandiso zvitsva zvinosimbisa iyo
Nguva yekutumira: Zvita-26-2023