Cellulose ethers ikirasi yeakagadziridzwa mapolymers akavakirwa paselulosi, ayo anoshandiswa zvakanyanya muindasitiri yemishonga nekuda kwehunhu hwawo hwakanaka hwemuviri nemakemikari. Mhando dzayo huru dzinosanganisira hydroxypropyl methylcellulose (HPMC), carboxymethyl cellulose (CMC) uye methyl cellulose (MC). Aya ma cellulose ethers ane huwandu hwakawanda hwekushandisa mumishonga, mahwendefa anovhara, capsules, gadziriro-yakasunungurwa-yakagadziriswa uye kugadzirira kwemvura.
1. Kushandisa mumapiritsi uye capsules
Mukugadzirira kwehwendefa uye capsule, cellulose ethers inowanzoshandiswa semabhaidhi, disintegrants uye zvinhu zvekuputira. Sezvisungo, vanogona kuwedzera kunamatira pakati pezvimedu zvezvinodhaka, kuitira kuti mahwendefa aite chimiro chakasimba nekuoma kwakakodzera uye nguva yekuparara. Cellulose ethers inogonawo kuvandudza kuyerera uye kusimba kwezvinodhaka uye kukurudzira kuumbwa kwakafanana.
Binders: Semuenzaniso, HPMC sebhainda inogona kugoverwa zvakaenzana pamusoro pezvimedu zvezvinodhaka, zvichipa yunifomu yekunamatira kuti ive nechokwadi chekuti mapiritsi anochengetedza chimiro chakagadzikana panguva yekumanikidza.
Disintegrants: Apo cellulose ethers inoputika mumvura, inogona kunyatsowedzera kuparara kwemapiritsi uye kuvimbisa kusunungurwa nokukurumidza kwemishonga. MC neCMC, sezvinokanganisa, zvinogona kukurumidza kuparara kwemapiritsi mudumbu remukati uye kuvandudza bioavailability yemishonga kuburikidza nehydrophilicity yavo uye kuzvimba.
Coating materials: Cellulose ethers seHPMC anowanzo shandiswa pakuputira mahwendefa uye capsules. Iyo yekuputira layer haigone kungovhara kuravira kwakashata kwemushonga, asi inopawo chidziviriro chekudzivirira kuti kuderedze kukanganiswa kwehunyoro hwezvakatipoteredza pakugadzikana kwezvinodhaka.
2. Kushandiswa mukugadzirira-kusunungurwa kwakasimba
Cellulose ethers inoita basa rinokosha mukugadzirisa-kusunungurwa kwegadziriro uye inonyanya kushandiswa kudzora kusunungurwa kwezvinodhaka. Nekugadzirisa mhando, viscosity uye kusungirirwa kwe cellulose ethers, vemishonga vanogona kugadzira akasiyana dhizaini ekuburitsa macurves kuti awane kunonoka kuburitswa, kudzorwa kuburitswa kana kuburitswa kwakanangwa.
Controlled release agents: Cellulose ethers akadai seHPMC neEC (ethyl cellulose) anoshandiswa seanodzorwa anoburitsa mahwendefa mumapiritsi anoramba achiburitswa. Vanogona kunyungudika zvishoma nezvishoma mumuviri kuti vagadzire gel layer, nekudaro vachidzora kuburitswa kwemushonga uye kuchengetedza iyo plasma kuunganidzwa kwemushonga.
Skeleton zvinhu: Mune skeleton inosimudzira-kusunungurwa gadziriro, cellulose ethers inoparadzira mushonga mumatrix nekugadzira network network kugadzirisa kuparara kwemushonga. Semuenzaniso, HPMC skeleton zvinhu zvinogadzira gels kana yaiswa mumvura, kudzivirira kukurumidza kupera kwezvinodhaka uye kuwana kutonga kwenguva refu.
3. Kushandiswa mukugadzirira kwemvura
Cellulose ethers inoshandiswa zvakanyanya seyakakora, inomisa maajenti uye inosimbisa mukugadzirira kwemvura. Vanogona kuwedzera viscosity uye kugadzikana kwegadziriro yemvura uye kudzivirira mushonga kubva pakugadzirisa kana stratifying panguva yekuchengetedza.
Thickeners: Cellulose ethers (seCMC) semakobvu anogona kuwedzera viscosity yegadziriro yemvura, kuve nechokwadi chekugovaniswa kwakafanana kwemishonga, uye kudzivirira kunaya kwezvinodhaka.
Suspending agents: HPMC uye MC inoshandiswa seanomisa maajenti mukugadzirira kwemvura kuti ave nechokwadi chekuti zvimedu zvakamiswa zvinogovaniswa zvakaenzana mukati mekugadzirira nekugadzira yakagadzikana colloidal system kudzivirira kupatsanurwa kwemishonga yemishonga.
Stabilizers: Cellulose ethers inogonawo kushandiswa sezvigadziro zvekuvandudza kemikari uye kugadzikana kwemuviri kwegadziriro yemvura panguva yekuchengetedza uye kuwedzera hupenyu hwesherufu yezvinodhaka.
4. Zvimwe zvikumbiro
Mukuwedzera, cellulose ethers inoshandiswawo mune transdermal kugadzirira uye ophthalmic kugadzirira muindasitiri yemishonga. Ivo vanoita sevagadziri vemafirimu uye viscosity inowedzera mune izvi maapplication kuvandudza kunamatira uye bioavailability yegadziriro.
Transdermal preparations: HPMC neCMC inowanzoshandiswa semafirimu ekugadzira mapeji e-transdermal, ayo anovandudza kutorwa kwemishonga yemishonga kuburikidza nekudzora kubuda kwemvura uye chiyero chekupinda kwemishonga.
Kugadzirira kweOphthalmic: Mukugadzirira kwemaziso, cellulose ethers inoshandiswa semafuta ekuvandudza kunamatira kwemishonga yemaziso, kurebesa nguva yekugara kwemishonga panzvimbo yemaziso, nekuvandudza maitiro ekurapa.
Iko kushandiswa kwakakura kwema cellulose ethers muindasitiri yemishonga kunobva kune yavo yakanakisa yemuviri uye makemikari zvimiro, seyakanaka biocompatibility, controllable solubility uye versatility kusangana nezvinodiwa zvekugadzirira kwakasiyana. Nekusarudza zvine musoro nekugadzirisa cellulose ethers, makambani emishonga anogona kuvandudza kunaka nekugadzikana kwegadziriro yezvinodhaka uye kusangana nevarwere zvinodiwa pakuchengetedza zvinodhaka uye kushanda. Nekuenderera mberi kwekufambira mberi kwehunyanzvi hwemishonga, tarisiro yekushandiswa kwe cellulose ethers ichave yakakura.
Nguva yekutumira: Jul-12-2024