Kutanga, chidimbu cheChirungu chezvinyorwa zvekubatsira
MC: Methyl cellulose
EC: ethyl cellulose
HPC: hydroxypropyl cellulose
HPMC: hydroxypropyl methylcellulose
CAP: Cellulose acetate phthalates
HPMCP: hydroxypropyl cellulose phthalates
HPMCAS: hydroxypropyl methyl cellulose acetate succinate
Cmc-na: Sodium carboxymethyl cellulose
MCC: Microcrystalline cellulose
PVP: Povidone
PEG: polyethylene glycol
PVA: Polyvinyl doro
Cms-na: Sodium carboxymethyl starch
PVPP: Muchinjikwa-yakabatana povidone
CCNa: crosslinked sodium carboxymethyl cellulose
Chechipiri, kushandiswa kwezvimwe zvinhu zvekubatsira
1. Lactose: tablet: filler, kunyanya poda yakananga tablet filler;Jekiseni: lyophilized inodzivirira
2. Microcrystalline cellulose: tablet: poda yakatsikirirwa tablet filler;"Dry adhesive";Mahwendefa ane 20% microcrystalline cellulose anoita se disintegrators
3. Methyl cellulose: tablet: adhesive;Suspension agent: kumiswa rubatsiro;Inononoka (inodzorwa) kusunungurwa kugadzirira: hydrophilic gel skeleton zvinhu (zvisina simba)
4 sodium carboxymethyl cellulose: mahwendefa: anonamatira;Suspension agent: kumiswa rubatsiro;Inononoka (inodzorwa) kusunungurwa kugadzirira: hydrophilic gel skeleton zvinhu
5. Ethyl cellulose: tablet: adhesive (insoluble mumvura);Kunonoka (kudzorwa) kusunungurwa kugadzirira: skeleton zvinhu kana membrane inodzorwa zvinhu;Solid dispersion: insoluble carrier material
6 hydroxypropyl cellulose: piritsi: adhesive, film coating material;Suspension agent: kumiswa rubatsiro;Inononoka (inodzorwa) kuburitsa kugadzirira: hydrophilic gel skeleton zvinhu, microporous membrane yakavharwa pepa pore-inducing agent.
7. Hydroxypropyl methyl cellulose (hydroxypropyl methyl cellulose) : tablet: adhesive, film coating material;Suspension agent: kumiswa rubatsiro;Inononoka uye inodzorwa kusunungurwa gadziriro: hydrophilic gel skeleton zvinhu, microporous membrane yakavharwa pepa pore-inducing agent.
8. Cellulose acetate phthalates: enteric zvinhu
9. Hydroxypropyl cellulose phthalates: enteric zvinhu
10. Hydroxypropyl cellulose acetate succinate: enteric zvinhu
11. Polyvinyl phthalate (PVAP) : enteric zvinhu
12. Styrene Maleic acid copolymer (StyMA): intestinal soluble zvinhu
13. Acrylic resin (enteric type I, II, III), Eudragit L, Eudragit S (dzimwe nguva Eudragit L100 kana Eudragit S 100) : enteric zvinhu
14.Eudragit RL, Eudragit RS: : Insoluble carrier zvinhu
15.Eudragit E (yakaenzana neacrylic IV): gastric soluble polymer zvinhu
16. Cellulose acetate: mvura isingasviki zvinhu, inogona kushandiswa kupfekedza kana kugadzira mapiritsi epombi yeosmotic.
17. Polyvinylpyrrolidone (povidone PVP) : mapiritsi: adhesives;Tablet: gastric soluble film coating material;Pellets: nifedipine pellets (yakasimba kupararira);Suspension agent: kumiswa rubatsiro;
Solid dispersion: mvura-soluble carrier material;Kunonoka (kudzorwa) kusunungurwa kugadzirira: hydrophilic colloid skeleton zvinhu;Inononoka (inodzorwa) kusunungurwa kugadzirira: pore-inducing agent mu microporous membrane coated tablets
18. Polyvinyl doro: mumiririri wefirimu: firimu kugadzira zvinhu, kumiswa rubatsiro
19. Sodium carboxymethyl starch: tablet: disintegrating agent
20. Muchinjikwa-yakabatana povidone: Tablet: disintegrant
21. Crosslinked sodium carboxymethyl cellulose: tablet: disintegrating agent
22. Yakaderera-inotsiva hydroxypropyl cellulose: Tablet: disintegrant
23. Polylactic acid: biodegradable polymer zvinhu, inoshandiswa kugadzira microspheres, nanoparticles, nezvimwe.
24. Glycerol (sorbitol propylene glycol inoshanda zvakanyanya kune glycerol)
Kugadzirira kwemvura: solvent, injection solvent, suspension aid, moisturizer
Plasticizer mu capsule uye coating zvinhu
Mafuta, transdermal delivery systems: kupinda mukati
Wedzera kunyorova kwezvinodhaka zvehydrophobic, osmotic pressure regulator mune intravenous mafuta emulsion.
Glycerin gelatin (yemafuta, suppositories, yakasimba dispersions)
25. Glycerin gelatin
Kudonha mapiritsi: mvura-soluble matrix
Suppository: mvura-soluble matrix
Mafuta: Mvura inonyungudika matrix
26. Sodium dodecyl sulfate (anionic surfactant)
Emulsions, zvizoro: emulsifiers
Wetting agent yekugadzirira kwakasimba / lubricant yemapiritsi
solubilizer
27. Polyethylene glycol (PEG)
Mahwendefa: Mvura-inonyungudika lubricant (PEG 4000, 6000)
Tablet: Plasticizer mune firimu coating prescription
Capsule: Yakapfava capsule isiri-oiri liquid yepakati (PEG 400)
Kudonha mapiritsi: Mvura-soluble matrix (PEG 4000, 6000,9300)
Suppository: suppository matrix
Aerosol: Latent solvent (PEG 400, 600)
Jekiseni: Solvent (PEG 400, 600)
Kugadzirira kwemvura: Solvent (PEG 400, 600)
Kupararira kwakasimba: mutakuri
Inononoka (inodzorwa) kusunungurwa kugadzirira: pore-inducing agent mu microporous membrane coated tablets
Percutaneous absorption kugadzirira: transdermal absorption enhancer
28. Poloxam (” zwitterionic “surfactant) Mumwe sahwira akangwarira akaona mutsauko pano, zvino wagadziriswa ku” Poloxam “non-ionic surfactant, kwete zwitterionic surfactant!
Solid dispersion carrier, suppository matrix, emulsifier yejekiseni kana infusion
Pfupiso yeantiseptic uye bacteriostatic agents
Hydroxyl benzene ester (neper gold), benzoic acid, sodium benzoate, sorbic acid, benzalkonium bromide (new clean out), benzalkonium chloride (jie er die), chlorhexidine acetate, benzyl alcohol (local pain) panguva imwe chete, yakabatana. ine tertiary butyl doro (marwadzo emunharaunda) panguva imwe chete, nitrobenzene, mercury, thimerosal, disinfection net, ortho-phenyl phenol, phenoxyethanol, eucalyptus mafuta, sinamoni mafuta, peppermint mafuta, nezvimwewo.
Chechina, sterillization nzira
1/ Glucose jekiseni, mafuta emulsion yejekiseni remutsinga, dextran, sodium chloride infusion, rubber plug uye kumwe kupisa kudzvanya sterilization;
2/ Vitamin C jekiseni, procaine hydrochloride jekiseni, cortisone acetate jekiseni, chloramphenicol ziso madonhwe akanga sterilized nekutenderera chiutsi;
3/ Mafuta ejekiseni, girisi matrix, ampoule uchishandisa yakaoma kupisa sterilization nzira;
4/ Asepsis mukamuri mhepo, kushanda tafura pamusoro: ultraviolet sterilization nzira kana gasi fumigation nzira;
5/ Ruoko, aseptic midziyo: makemikari sterilization nzira
6/ Insulin jekiseni uye zvimwe zvipenyu zvigadzirwa: filtration sterilization nzira
V. Related equations
1. Noyes-whitney equation: inotsanangura kuparara kwemishonga yakasimba.
2. Yakakosha hama humidity yemusanganiswa
hygroscopicity yeP68 poda)
3. Kutsiva mutengosuppository P87)
4.Poiseuile formula: tsanangura izvo zvinofurira zvinhu zvekusefa (jekiseni P124)
5. Calculation formula ye isotonic regulation nechando chekudzikisa nzirajekiseni P156)
6. Kuverengera kweHLB kukosha kwemusanganiswa surfactantmvura P178)
Tekinoroji yekugadzirira yakakodzera
1. Microcapsule: condensation nzira (kamwe, yakaoma), solvent-isina-kunyungudika nzira, kushandura tembiricha nzira, mvura kuomeswa nzira, spray drying nzira, spray condensation nzira, air kuturika nzira, interface condensation nzira, mwaranzi crosslinking nzira.
2. Kusanganisirwa musanganiswa: saturated aqueous solution nzira, kugaya nzira, kuomesa nechando nzira, pfapfaidzo yekuomesa
3. Kunyunguduka kwakasimba: nzira yekunyunguduka, nzira yekunyungudutsa, nyungudika - nzira yekunyungudutsa, nyungudika - pfapfaidzo yekuomesa nzira, nzira yekukuya
4. Liposomes: jekiseni nzira, nhete firimu dispersion nzira, ultrasonic dispersion nzira, reverse phase evaporation nzira, kuomesa nechando nzira.
5. Microspheres: emulsification - kurapa nzira, spray drying nzira, mvura yakaoma nzira
6. Nanoparticles: micellar polymerization, emulsion polymerization, interfacial polymerization, mvura kuomesa nzira.
7. Pellet: kubikira granulation nzira, pfapfaidza granulation nzira, coating poto nzira, extrusion sphericity nzira, centrifugal projectile nzira, mvura kuomesa nzira.
8 suppository: nzira yekunyungudika inopisa, nzira yekutsikirira inotonhora, nzira yekukanya
9. Mafuta: nzira yekukuya, nzira yekunyungudutsa, emulsification nzira
10 mumiriri wemufirimu: homogenized slurry kuyerera firimu nzira yekugadzira, kumanikidza-kunyungudutsa firimu nzira yekugadzira, nzira yekugadzira firimu inosanganiswa.
Zvinomwe, zvishongedzo zvemumiririri
1. Microcapsule: gelatin - Arabic gum
2. Inclusion compound: cyclodextrin
3. Kupararira kwakasimba: PEG, PVP
4. Liposomes: phospholipid-cholesterol
5. Microspheres: gelatin, albumin, PLA, nezvimwewo
6. Suppository: cocoa butter
7. Mafuta: Petroleum jelly, nezvimwewo
8 firimu mumiririri: PVA
Sere, nguva shoma
1. Iyo sterilized ampoule ichasiiwa kweanopfuura maawa makumi maviri nemana;
2. Kuchengetwa kwemvura yejekiseni hakufaniri kudarika maawa gumi nemaviri;
3. Kuvharirwa kwemajekiseni akazara kuchapedzwa mukati memaawa gumi nemaviri mushure mekubika;
4. Infusion uye kugadziriswa kwekugadzirisa kuchapedzwa mukati maawa mana ekubereka
9. Zvinhu zvekuongorora zvehutano zvine chokuita nekugadzirira kwemishonga
1. Mahwendefa: maitiro ekuonekwa;Slice uremu musiyano;Kuoma uye brittleness;Disintegrating degree;Kuparara kana kusunungurwa;Kufanana kwezvinhu
2. Mumiririri wekuparadzira: kufanana;Unyoro.Loading quantity difference;Kuongororwa kwehutano;Granularity kuongorora
3. Granule: chitarisiko;Particle size;Dry uremu kurasikirwa;Melt;Musiyano wemutoro
4. Capsule: kuonekwa;Unyoro.Loading quantity difference;Kuparara uye kuparara.
5. Kudonha mapiritsi: uremu musiyano;Dissolution nguva yakatarwa yekuongorora, nezvimwe.
6. Suppository: chitarisiko;Kusiyana kwehuremu;Nguva yekunyunguduka;Melting point range;In vitro dissolution bvunzo uye mu vivo absorption bvunzo
7. Plaster: particle size;The load;Microbial muganhu;Main drug content;Physical properties;Stimulus;Kugadzikana;Kusunungurwa, kupinda uye kutorwa kwemishonga mumafuta.
8. Transdermal patches: uremu musiyano;Area difference;Uniformity yezvinyorwa;Dhigirii rekuburitsa, nezvimwe.
10. Tsanangudzo dzakasiyana
1. Micro capsule: kapisi kadiki kadiki kanoumbwa nekuputira mushonga wakasimba kana wemvura (unonzi capsule core) mune yakasikwa kana synthetic polymer material (inonzi capsule material).1-5000 microns
2. Pellet: inoreva denderedzwa rine dhayamita isingasviki 2.5mm inoumbwa nemishonga uye ekuwedzera.
3. Microsphere: skeleton-type microscopic spherical entity inoumbwa nekunyunguduka kana kuparadzira mishonga muhutano hwezvinhu zvepolymer, ine chidimbu chekukura kazhinji pakati pe1 ne250μm.
4. Nanoparticles: yakasimba colloidal particles inoumbwa nezvinhu zvepolymeric, ine particle size muhuwandu hwe10 ~ 1000nm.
5. Droping pill agent: inoreva mishonga yakasimba kana yemvura uye zvinhu zvakakodzera (zvinowanzozivikanwa sematrix) kupisa kunyunguduka musanganiswa, kudonha mumiscible condensate, condensation condensation uye yakagadzirwa nediki pellet kugadzirira.
Nguva yekutumira: Sep-09-2022