HPC (Hydroxypropyl Cellulose) uye HPMC (Hydroxypropyl Methylcellulose) zvinhu zviviri zvinonyungudika nemvura zvinobva muselulosi zvinowanzoshandiswa mumaindasitiri emishonga, ezvekudya uye emakemikari. Kunyangwe iwo akafanana mune zvimwe zvinhu, zvimiro zvavo zvemakemikari, zvivakwa uye mamiriro ekushandisa akasiyana zvakanyanya.
1. Chimiro chemakemikari
HPC: HPC inobuda muchidimbu hydroxypropylated ye cellulose. Inogadzirwa nekuita cellulose nepropylene oxide uye kuunza hydroxypropyl mapoka (-CH2CHOHCH3). Muchimiro cheHPC, chikamu chemapoka e-hydroxyl emusana we cellulose anotsiviwa nemapoka e-hydroxypropyl, zvichiita kuti inyunguduke nemvura uye thermoplastic.
HPMC: HPMC iine chikamu hydroxypropylated uye methylated kubva kune cellulose. Iyo inogadzirirwa nekuunza hydroxypropyl mapoka uye methoxy mapoka (-OCH3) mu cellulose. Iyo molecular chimiro cheHPMC yakanyanya kuomarara, nekuunzwa kwemapoka ehydroxypropyl uye methyl inotsiva.
2. Muviri uye makemikari zvinhu
Solubility: Ose ari maviri-anonyungudika mapolymer, asi maitiro avo ekunyungudika akasiyana. HPC ine kunyungudika kwakanaka mumvura inotonhora uye mamwe organic solvents (senge ethanol, propanol, nezvimwewo), asi solubility yayo inogona kuderera pakudziya kwepamusoro (inenge 45 ° C kana pamusoro). HPMC ine yakanakisa solubility mumvura inotonhora, asi ine gelling zvivakwa mumvura yakakwirira-yekupisa, ndiko kuti, iyo yakakwirira tembiricha, iyo HPMC yakanyungudika mumvura inoumba gel uye haichazonyungudika.
Thermal kugadzikana: HPC ine yakanaka thermoplasticity, zvinoreva kuti inogona kupfava kana kunyunguduka pane tembiricha yepamusoro, saka inowanzoshandiswa mune thermoplastic molding zvinhu. HPMC ine kupisa kwakanyanya kuramba, haisi nyore kunyunguduka kana kupfava, uye inokodzera kushandiswa pasi pemamiriro ekushisa.
Viscosity: HPMC kazhinji ine viscosity yakakwirira kupfuura HPC, kunyanya muindasitiri yemishonga, HPMC inowanzoshandiswa mukuumbwa kunoda kusungirirwa kwakasimba kana kuvhara, nepo HPC inoshandiswa mumamiriro ezvinhu apo kudiwa kwepakati kana kuderera kunodiwa.
3. Minda yekushandisa
Pharmaceutical field:
HPC: HPC inyanzvi yemishonga, inonyanya kushandiswa sepiritsi yekunamira, capsule shell film-forming agent, uye matrix zvinhu zvekudzora kuburitswa kwezvinodhaka. Nekuda kweiyo thermoplasticity, yakakodzerawo kune mamwe anopisa melt process gadziriro. HPC zvakare ine yakanaka biocompatibility uye kudzikira, uye inokodzera kushandiswa senge intraoral drug delivery system.
HPMC: HPMC inonyanya kushandiswa muindasitiri yemishonga, uye inowanzoshandiswa senge matrix zvinhu, coating material, thickener uye stabilizer yematablets anoramba achiburitswa. Iyo gelling zvimiro zveHPMC inoita kuti ive yakanaka kuburitsa zvinodhaka kudzora zvinhu, kunyanya mudumbu remukati, kwaanogona kunyatso kudzora mwero wekuburitswa kwezvinodhaka. Yayo yakanaka yekugadzira firimu inoita kuti ive sarudzo huru yekuputira piritsi uye particle coating.
Nzvimbo yekudya:
HPC: Muindasitiri yechikafu, HPC inogona kushandiswa seyakakora, stabilizer uye emulsifier kuvandudza magadzirirwo uye kutaridzika kwechikafu. Mune zvimwe zviitiko, inogona zvakare kushandiswa sechinhu chinodyiwa chemufirimu kune zvimwe zvekudya zvinoda kuchengetwa zvakanyorova kana kuparadzaniswa.
HPMC: HPMC inowanzoshandiswa seyakakora, emulsifier uye stabilizer muindasitiri yezvekudya, kunyanya muzvigadzirwa zvakabikwa sechingwa nemakeke. HPMC inobatsira kuvandudza chimiro uye kuumbwa kwehupfu uye kuwedzera hupenyu hwesherufu yechikafu. Pamusoro pezvo, HPMC inoshandiswawo zvakanyanya mukudya kwemuriwo sechinhu chinomiririra chirimwa kutsiva mhuka collagen.
Cosmetics uye zvigadzirwa zvekuchengeta munhu:
Ose ari maviri HPC uye HPMC anogona kushandiswa muzvizora semafuta, anosimbisa uye mafirimu ekutanga. Semuenzaniso, vanogona kushandiswa mukuchengetwa kweganda uye zvigadzirwa zvebvudzi kuvandudza kubata uye kugadzikana kwechigadzirwa. HPMC inowanzova yakakodzera seyakajeka colloid mumiriri, senge gobvu mumadonhwe eziso, nepo HPC inowanzoshandiswa mumamiriro ezvinhu apo jasi rinochinjika rinoda kuumbwa.
Zvishandiso zvekuvaka uye machira:
HPMC: Nekuda kwekunamira kwayo kwakanaka uye kuchengetwa kwemvura, HPMC inoshandiswa zvakanyanya mukuvaka senge simende, dhaka, putty uye gypsum kusimudzira kunamatira uye kunatsiridza kuita kwekuvaka.
HPC: Kusiyana neizvi, HPC hainyanyi kushandiswa muindasitiri yekuvaka uye inowanzo shandiswa sechinhu chinowedzera kana chinonamira pakupfeka.
4. Kuchengetedza uye kuchengetedzwa kwezvakatipoteredza
Ose ari maviri HPC neHPMC anoonekwa seakachengeteka zvinhu uye anoshandiswa zvakanyanya mukudya, mishonga uye zvigadzirwa zvekuchengeta munhu. Vese vari vaviri vane yakanaka biocompatibility uye kudzikira, uye haizokonzerese zvine muchetura mhedzisiro kumuviri wemunhu. Nekudaro, sezvo ivo vasina kunyura mumuviri wemunhu uye vachingoshandiswa sezvinhu zvekubatsira, kazhinji havana systemic mhedzisiro pamuviri wemunhu. Pamusoro pezvo, maitiro ekugadzira eHPC neHPMC ane hushamwari kwezvakatipoteredza, uye makemikari nezvinonyungudutsa zvinoshandiswa mukugadzira zvinogona kunyatsoshandiswa zvakare uye kushandiswa zvakare.
Kunyangwe HPC neHPMC zvese zviri zviviri zvinobva kune cellulose uye zvine muchinjiko-kushandisa mune mamwe maapplication, iwo ane misiyano yakakura muchimiro chemakemikari, zvimiro zvemuviri uye nzvimbo dzekushandisa. HPC inonyanya kukodzera kune zvikumbiro zvinoda thermoplastic zvinhu, senge inodzorwa kuburitswa kwezvinodhaka uye kupisa kunyunguduka maitiro, nepo HPMC ichishandiswa zvakanyanya mumishonga, chikafu, kuvaka nemimwe minda nekuda kwekunamira kwayo, firimu-kuumba zvivakwa uye kuchengetedza mvura. . Naizvozvo, ndechipi chinyorwa chekusarudza zvinoenderana nezvinodiwa zvekushandisa.
Nguva yekutumira: Oct-22-2024