Hydroxypropyl Methylcellulose (HPMC) ndeye semi-synthetic, inert, yakakwirira-viscosity polymer inoshandiswa zvakanyanya mukugadzira zvinodhaka. Yayo yakasarudzika yemuviri uye makemikari zvimiro inoita kuti ive yakakosha mubairo muindasitiri yemishonga, ine firimu-kuumba, kukora, kugadzikana uye biocompatibility.
Basic zvimiro zveHPMC
HPMC inogadzirwa nemethylating uye hydroxypropylating cellulose. Iyo ine yakanaka solubility yemvura uye thermoplasticity, uye inonyungudika nekukurumidza mumvura inotonhora kuita inoonekera colloidal mhinduro. Kunyungudika kwayo uye viscosity inogona kudzorwa nekugadzirisa dhigirii rekutsiva uye dhigirii repolymerization, izvo zvinobvumira HPMC kusangana nezvinodiwa zvemhando dzakasiyana dzemishonga.
Nzvimbo dzekushandisa
1. Mishonga inodzorwa-inoburitswa
HPMC inoshandiswa zvakanyanya mukugadzirira kwemishonga inodzorwa-inoburitswa. Nekuda kwekunyungudika kwayo mumvura uye kugona kugadzira gels, HPMC inogona kudzora kuburitswa kwezvinodhaka. Kuzvimba kwaro mudumbu remukati kunobvumira mushonga wacho kuti usunungurwe zvishoma nezvishoma pane imwe nguva yenguva, kunyatso kudzora kusanganiswa kweplasma yemushonga, kuderedza kuwanda kwemishonga, nekuvandudza kuterera kwemurwere.
2. Binders uye disintegrants zvemapiritsi
Sebhainda uye disintegrant yemapiritsi, HPMC inogona kukwidziridza simba remagetsi remapiritsi uku ichiona kuti mahwendefa anoparara uye kuburitsa zvinhu zvinoshanda munguva yakakodzera. Zvinhu zvaro zvakanamatira zvinobatsira kusunga mishonga yemishonga pamwe chete kuti iite piritsi yakasimba, nepo kuputika kwayo kunobvumira mahwendefa kuti aparadze nokukurumidza mumvura.
3. Mafirimu ekuputira vamiririri
HPMC chinhu chakakosha pakugadzira zvinodhaka firimu coatings. Inogona kushandiswa sechidziviriro chefirimu chifukidzo chekudzivirira mushonga kubva kune unyoro, okisijeni uye chiedza, nokudaro kuvandudza kugadzikana kwemushonga. Pamusoro pezvo, HPMC inogona zvakare kushandiswa senge enteric coating kuchengetedza mushonga kubva pakuburitswa mudumbu uye kuve nechokwadi chekuti mushonga unonyudzwa muura.
4. Ophthalmic kugadzirira
Mukugadzirira kwemaziso, HPMC inowanzoshandiswa kugadzirira misodzi yekugadzira uye madonhwe emeso. Yayo yakakwirira viscosity uye biocompatibility inoita kuti igadzire firimu rekudzivirira pamusoro peziso, kuchenesa ziso, uye kubvisa yakaoma zviratidzo zveziso.
5. Capsules
HPMC inogona kushandiswa kugadzirira yakaoma capsules uye akapfava capsules. Kuenzaniswa neyakajairwa gelatin capsules, HPMC capsules ine nani kugadzikana kwekemikari, haisi nyore kutora unyoro, uye inoshamwaridzana kune vanodya miriwo uye vanonamata.
Kufurira zvinhu
1. Viscosity
Iyo viscosity yeHPMC ndeimwe yezviratidzo zvakakosha zvekuita kwayo. High-viscosity HPMC inogona kushandiswa kudzorwa-kuburitsa zvinodhaka uye firimu-yakavharidzirwa gadziriro, nepo yakaderera-viscosity HPMC inonyanya kukodzera kushandiswa sebhainda uye disintegrant.
2. Dhigirii rekutsiva
Iyo dhigirii yekutsiva (DS) uye molar substitution (MS) yeHPMC inokanganisa zvakananga kunyungudika kwayo uye kugona kwekugadzira gel. Kugadziriswa kwakaringana kwedhigirii rekutsiva kunogona kukwidziridza mashandisiro ekushandisa kweHPMC mune dzakasiyana dhiza magadzirirwo.
3. Zvinhu zvakatipoteredza
Kuita kweHPMC kunokanganiswawo nemamiriro ekunze akadai setembiricha, pH kukosha uye ionic simba. Izvi zvinhu zvinofanirwa kutariswa kana uchigadzira magadzirirwo emishonga kuona kuti HPMC inoita zvakanaka.
Hydroxypropyl methylcellulose (HPMC), semushonga wakawanda, wepamusoro-wekuita mishonga yemishonga, inoshandiswa zvakanyanya muminda yakawanda senge zvinodhaka zvinodzorwa kusunungurwa, mahwendefa, firimu-coated gadziriro, ophthalmic kugadzirira uye capsules. Nekugadzirisa viscosity yayo uye dhigirii yekutsiva, inogona kusangana nezvinodiwa zvakasiyana-siyana zvemishonga yemishonga uye inovandudza zvakanyanya kugadzikana uye bioavailability yemishonga. Nekuenderera mberi kwekufambira mberi kwehunyanzvi hwemishonga, tarisiro yekushandiswa kweHPMC ichave yakakura.
Nguva yekutumira: Jul-11-2024