HPMC K4M (hydroxypropyl methylcellulose K4M) inowanzoshandiswa muindasitiri yemishonga, kunyanya mumapiritsi anoramba achiburitswa, gadziriro dzinodzorwa-kuburitswa uye mamwe magadzirirwo akasimba emuromo.
Basic zvimiro zveHPMC K4M
HPMC K4M igiredhi rakajairwa reHydroxypropyl Methylcellulose (HPMC). HPMC ndeye semi-synthetic, yakakwira molecular uremu multifunctional polymer zvinhu zvakagadzirwa kubva kumakemikari akagadziridzwa cellulose ane yakanaka yemuviri uye kemikari zvimiro, senge yakanakisa thickening, gelling, firimu-kugadzira uye adhesive zvivakwa.
HPMC K4M inoshandiswa zvakanyanya mundima yemishonga nekuda kweiyo yepakati viscosity uye yakanakisa kukora uye firimu-kugadzira zvivakwa. "K" muK4M inomirira high viscosity cellulose, uye "4M" inoreva kuti viscosity yayo inenge 4000 centipoise (inoyerwa mu 2% aqueous solution).
Mashandisirwo makuru eHPMC K4M muindasitiri yemishonga
1. Kushandiswa mukugadzirira-kusunungurwa kwakasimba
Basa guru reHPMC K4M mukugadzirisa-kusunungurwa gadziriro ndeyekushanda sechinhu chinodzorwa-kuburitsa matrix zvinhu. Yayo yakasarudzika hydrophilicity uye gel-kuumba kugona kunoita kuti ive imwe yeanonyanya kushandiswa maexcipients mune inoenderera-inoburitsa zvinodhaka kuburitsa masisitimu. HPMC K4M inogona kukurumidza kunwisa mvura uye kuzvimba kana yasangana nemvura, uye kugadzira gel layer pamusoro pepiritsi, ichinonotsa kuburitswa kwemushonga, nekudaro kuwana inodzorwa yekuburitsa mhedzisiro.
Iyi pfuma inonyanya kukodzera mahwendefa emuromo anoramba achiburitswa, senge antihypertensive zvinodhaka, antidiabetic zvinodhaka, uye analgesics. Nekushandisa HPMC K4M, mushonga unogona kuramba uchiburitswa mumuviri, uchichengeta dhaka remuropa nguva dzose, kuderedza kuwanda kwemishonga, nekuvandudza kuterera kwemurwere.
2. Capsules uye kupfeka zvinhu
HPMC K4M, sechinhu chekuputira, inogona kuumba firimu rekudzivirira pamusoro pekugadzirira. Iyo firimu ine zvakanaka zvipingamupinyi zvivakwa, izvo zvinokwanisa kudzivirira mushonga kubva pakusvibiswa nehunyoro, oxidation kana chiedza, uye kurebesa kugadzikana uye pasherufu hupenyu hwemushonga. Kusiyana negelatin yechinyakare, HPMC inotorwa nechirimwa, saka yakakodzera kune vanodya miriwo uye varwere vasingawirirani nemhuka-yakatorwa zvigadzirwa.
HPMC K4M inogonawo kushandiswa sechinhu chekugadzirira mabhomba e capsule, kutsiva gelatin capsules, uye inoshandiswa mukuvharirwa kwemakapulisi ezvinomera uye zvinodhaka zvinodhaka, zvine biocompatibility uye kuchengeteka.
3. Semukobvu uye bhainda
Muindasitiri yemishonga, HPMC K4M inoshandiswa zvakanyanya mukunyorova kwegranulation maitiro sebhainda kukurudzira kuumbwa kwezvikamu. Izvo zvakanakisa zvisungo zvekubatanidza zvinogona kuve nechokwadi chekuti zvimedu zvine kuoma kwakanaka uye kuparara, kuve nechokwadi kuti mahwendefa anogona kukurumidza kuparara uye kuburitsa mushonga kana watorwa. Uye zvakare, HPMC K4M inogona zvakare kushandiswa seyakakora mukugadzirira kwemvura, senge suspensions uye ophthalmic kugadzirira, kuwedzera viscosity uye kugadzikana kwegadziriro.
4. Stabilizer uye mumiririri anodzivirira
HPMC K4M inogona kuita seyakagadzikana uye inodzivirira mumiriri mune dzimwe gadziriro, kunyanya mune multiphase masisitimu akadai emulsions uye suspensions. Kuwedzera kwayo uye kugona kugadzira gel kunogona kudzivirira mushonga kubva pakugadzirisa kana stratifying panguva yekuchengetedza, kuve nechokwadi chekufanana uye kugadzikana kwegadziriro. Mukuwedzera, mune mamwe madhiragi ezvipenyu kana mapuroteni zvinodhaka, HPMC K4M inogona kushandiswa sechinhu chinodzivirira kudzivirira puroteni kubva ku denaturing kana kushatisa panguva yekugadzirira kana kuchengetedza, kuve nechokwadi chekuita kwehupenyu hwemushonga.
5. Mucosal absorption enhancer
Mumakore achangopfuura, zvidzidzo zvakaratidza kuti HPMC K4M inogona kushandiswa semucosal absorption enhancer kubatsira kuvandudza bioavailability yeimwe yakaoma-kunwa zvinodhaka. Semuenzaniso, nekubatanidza neHPMC K4M, mamwe mapuroteni uye peptide mishonga inogona kunyudzwa zvirinani munzvimbo dzemucosal dzakadai semuromo wemukanwa, mhino kana rectum, kudzivirira nzira yechinyakare yejekiseni uye nekupa imwe nzira iri nyore uye isiri-invasive yekutonga.
6. Basa rekugadzirisa kusunungurwa kwezvinodhaka
HPMC K4M haigone kushandiswa senge imwe chete inodzorwa kuburitsa matrix, asi zvakare inogona kushandiswa pamwe chete nezvimwe zvinodzorwa kuburitsa zvinhu (senge carbomer, ethyl cellulose, nezvimwewo) kuti synergistically kudzora kuburitswa kwezvinodhaka. Nekushandura kusungirirwa, huremu hwemamorekuru kana chiyero cheHPMC K4M nezvimwe zvinobatsira, mainjiniya ekugadzira mishonga anogona kunyatsogadzirisa kuburitswa kwemishonga kuti isangane nezvido zvekurapa zvemishonga yakasiyana.
Zvakanakira zveHPMC K4M mune zvemishonga
Kuchengeteka kwakanaka uye biocompatibility: HPMC K4M isiri-chepfu, isingatsamwire zvinhu, uye sosi yacho ndeye cellulose yechisikigo, inokodzera kushandiswa kwenguva refu. Sezvo HPMC K4M isingavimbi ne intestinal enzyme degradation, nzira yayo ye metabolic mumuviri yakapfava, ichidzikisa njodzi inogona kuitika.
Zviri nyore kushandisa: HPMC K4M inogona kunyungudika mumvura inotonhora uye inopisa, uye mhinduro ine kugadzikana kwakanaka uye iri nyore kushandisa. Yayo firimu-kuumba uye gel-kuumba kugona kunopa iyo yakanaka maitiro ekugadzirisa mune yemishonga maitiro.
Yakasiyana-siyana yezvikumbiro: HPMC K4M haikodzere chete kugadzirira kwemuromo kwakasimba, asiwo kune akasiyana mamwe mafomu ekuyeresa, senge topical kugadzirira, ophthalmic gadziriro, jekiseni uye inhalation gadziriro.
Semubatsiri wemishonga yakawanda, HPMC K4M inogara pachinzvimbo chakakosha muindasitiri yemishonga ine hunhu hwayo hwakanaka hwemuviri uye kemikari uye huwandu hwakasiyana hwemashandisirwo. Iyo ine mhedzisiro yakakosha muzvinhu zvakawanda senge inoenderera-kuburitswa gadziriro, thickeners, coating zvinhu, stabilizers, nezvimwewo, kunyanya pakugadzirwa kwemuromo-inoburitswa mahwendefa, ine zvakanakira zvisingadzokerike. Nekuenderera mberi nekuenderera mberi kwehunyanzvi hwekugadzira mishonga, tarisiro yekushandiswa kweHPMC K4M ichave yakakura, uye chinzvimbo chayo mugadziriro yemishonga mitsva icharamba ichivandudza.
Nguva yekutumira: Sep-29-2024